Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis

Etrasimod (APD334) is an oral, selective sphingosine 1-phosphate receptor modulator in development for immune-mediated inflammatory disorders. We assessed the efficacy and safety of etrasimod in patients with moderately to severely active ulcerative colitis (UC). In a phase 2, proof-of-concept, doub...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2020-02, Vol.158 (3), p.550-561
Hauptverfasser:	Sandborn, William J., Peyrin-Biroulet, Laurent, Zhang, Jinkun, Chiorean, Michael, Vermeire, Séverine, Lee, Scott D., Kühbacher, Tanja, Yacyshyn, Bruce, Cabell, Christopher H., Naik, Snehal U., Klassen, Preston, Panés, Julián
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - administration & dosage Acetates - adverse effects Adult Asymptomatic Diseases - epidemiology Atrioventricular Block - chemically induced Atrioventricular Block - epidemiology Colitis, Ulcerative - complications Colitis, Ulcerative - diagnosis Colitis, Ulcerative - drug therapy Colitis, Ulcerative - immunology Colon - diagnostic imaging Colon - drug effects Colon - pathology Colonoscopy Dose-Response Relationship, Drug Double-Blind Method Female Gastrointestinal Hemorrhage - diagnosis Gastrointestinal Hemorrhage - epidemiology Gastrointestinal Hemorrhage - etiology Gastrointestinal Hemorrhage - prevention & control Humans Immunomodulatory Therapy Indoles - administration & dosage Indoles - adverse effects Induction Chemotherapy - adverse effects Induction Chemotherapy - methods Inflammatory Bowel Disease Intestinal Mucosa - diagnostic imaging Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Male Middle Aged Placebos - administration & dosage Placebos - adverse effects Proof of Concept Study Rectum S1P Receptor Modulator Severity of Illness Index Sphingosine-1-Phosphate Receptors - immunology Sphingosine-1-Phosphate Receptors - metabolism Treatment Outcome Ulcerative Colitis
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