B cells in autoimmune and neurodegenerative central nervous system diseases

B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytoki...

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Veröffentlicht in:	Nature reviews. Neuroscience 2019-12, Vol.20 (12), p.728-745
Hauptverfasser:	Sabatino, Joseph J., Pröbstel, Anne-Katrin, Zamvil, Scott S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/1283 631/378/1689/364 631/378/371 631/378/87 Adaptive Immunity - drug effects Adaptive Immunity - immunology Alzheimer's disease Animal Genetics and Genomics Animals Antigen presentation Autoantibodies Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmunity B cells B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - pathology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Care and treatment Central nervous system Central nervous system diseases Central Nervous System Diseases - drug therapy Central Nervous System Diseases - immunology Central Nervous System Diseases - pathology Cytokines Development and progression Disease Humans Immune response Immunity Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Inflammation Lymphocytes B Lymphocytes T Movement disorders Multiple sclerosis Nervous system Nervous system diseases Neurobiology Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - immunology Neurodegenerative Diseases - pathology Neuromyelitis Neurosciences Parkinson's disease Pathogenesis Review Article T cells
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