Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation
Purpose The purpose of this study was to retrospectively investigate the effect of the severity of acute graft-versus-host disease (GVHD) on physical function after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods 76 patients were included as subjects of this study. Severity o...
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| Veröffentlicht in: | Supportive care in cancer 2020-07, Vol.28 (7), p.3189-3196 |
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| creator | Hamada, Ryota Kondo, Tadakazu Murao, Masanobu Miyasaka, Jyunsuke Yoshida, Michiko Nankaku, Manabu Kanda, Junya Takaori-Kondo, Akifumi Ikeguchi, Ryosuke Matsuda, Shuichi |
| description | Purpose
The purpose of this study was to retrospectively investigate the effect of the severity of acute graft-versus-host disease (GVHD) on physical function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods
76 patients were included as subjects of this study. Severity of acute GVHD was classified according to the method defined by Grucksberg. To evaluate physical function, the knee extensor strength and six-minute walk distance (6MWD) were performed.
Results
Among these patients, 54% developed acute GVHD; of these, 32%, 54%, and 15% of patients had grade I, grade II, and grades III–IV GVHD, respectively. In the grade I–II groups, mild acute GVHD following allo-HSCT resulted in a gradual decline in physical function, which improved at discharge. However, in cases of severe acute GVHD, physical function deteriorated, implementation of rehabilitation became difficult, and the decline in physical function persisted even at discharge.
Conclusion
These results indicate that severe acute GVHD negatively affects physical function leading to longer hospital days because of inadequate rehabilitation interventions. |
| doi_str_mv | 10.1007/s00520-019-05124-1 |
| format | Article |
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The purpose of this study was to retrospectively investigate the effect of the severity of acute graft-versus-host disease (GVHD) on physical function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods
76 patients were included as subjects of this study. Severity of acute GVHD was classified according to the method defined by Grucksberg. To evaluate physical function, the knee extensor strength and six-minute walk distance (6MWD) were performed.
Results
Among these patients, 54% developed acute GVHD; of these, 32%, 54%, and 15% of patients had grade I, grade II, and grades III–IV GVHD, respectively. In the grade I–II groups, mild acute GVHD following allo-HSCT resulted in a gradual decline in physical function, which improved at discharge. However, in cases of severe acute GVHD, physical function deteriorated, implementation of rehabilitation became difficult, and the decline in physical function persisted even at discharge.
Conclusion
These results indicate that severe acute GVHD negatively affects physical function leading to longer hospital days because of inadequate rehabilitation interventions.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-019-05124-1</identifier><identifier>PMID: 31712955</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer therapies ; Graft versus host disease ; Hematopoietic stem cells ; Knee ; Medical colleges ; Medicine ; Medicine & Public Health ; Mobility ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Palliative care ; Rehabilitation Medicine ; Side effects ; Stem cell transplantation ; Stem cells ; Transplantation ; Transplants & implants ; Walking</subject><ispartof>Supportive care in cancer, 2020-07, Vol.28 (7), p.3189-3196</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-8783ca75c7116b8539664db5ac94442e6cb71dfe152940a52c989a0658fcac823</citedby><cites>FETCH-LOGICAL-c596t-8783ca75c7116b8539664db5ac94442e6cb71dfe152940a52c989a0658fcac823</cites><orcidid>0000-0002-8959-6271</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-019-05124-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-019-05124-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31712955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamada, Ryota</creatorcontrib><creatorcontrib>Kondo, Tadakazu</creatorcontrib><creatorcontrib>Murao, Masanobu</creatorcontrib><creatorcontrib>Miyasaka, Jyunsuke</creatorcontrib><creatorcontrib>Yoshida, Michiko</creatorcontrib><creatorcontrib>Nankaku, Manabu</creatorcontrib><creatorcontrib>Kanda, Junya</creatorcontrib><creatorcontrib>Takaori-Kondo, Akifumi</creatorcontrib><creatorcontrib>Ikeguchi, Ryosuke</creatorcontrib><creatorcontrib>Matsuda, Shuichi</creatorcontrib><title>Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
The purpose of this study was to retrospectively investigate the effect of the severity of acute graft-versus-host disease (GVHD) on physical function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods
76 patients were included as subjects of this study. Severity of acute GVHD was classified according to the method defined by Grucksberg. To evaluate physical function, the knee extensor strength and six-minute walk distance (6MWD) were performed.
Results
Among these patients, 54% developed acute GVHD; of these, 32%, 54%, and 15% of patients had grade I, grade II, and grades III–IV GVHD, respectively. In the grade I–II groups, mild acute GVHD following allo-HSCT resulted in a gradual decline in physical function, which improved at discharge. However, in cases of severe acute GVHD, physical function deteriorated, implementation of rehabilitation became difficult, and the decline in physical function persisted even at discharge.
Conclusion
These results indicate that severe acute GVHD negatively affects physical function leading to longer hospital days because of inadequate rehabilitation interventions.</description><subject>Cancer therapies</subject><subject>Graft versus host disease</subject><subject>Hematopoietic stem cells</subject><subject>Knee</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mobility</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Palliative care</subject><subject>Rehabilitation Medicine</subject><subject>Side effects</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Walking</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc-KFDEQxoMo7rj6Ah4k4MVL1vztdI7Lsq7Cghc9h0y6MpOluzMmaWGewNc27ey6KCI5hKr6fR9VfAi9ZvSCUarfF0oVp4QyQ6hiXBL2BG2YFIJoIcxTtKFGMiKFUmfoRSl3lDKtFX-OzgTTjBulNujHdQjgK04B1z3gAt8hx3pca-eXCniXXaikdctSyD6ViodYwBXAacaH_bFE70YcltnX2DoNhozdOKYdzBA93sPkajqkCLVVpcKEPYwjrtnN5TC6ubpV-BI9C24s8Or-P0dfP1x_ufpIbj_ffLq6vCVema6SXvfCO628Zqzb9kqYrpPDVjlvpJQcOr_VbAjAFDeSOsW96Y2jneqDd77n4hy9O_kecvq2QKl2imVdyM2QlmK5YJIy2hnR0Ld_oXdpyXPbznJJtTSGG_5I7dwINs4htcv8amovO65Yz7VUjbr4B9XeAFP0aYYQW_8PAT8JfE6lZAj2kOPk8tEyatf07Sl929K3v9K3rIne3G-8bCcYfkse4m6AOAGljeYd5MeT_mP7E0JOul4</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Hamada, Ryota</creator><creator>Kondo, Tadakazu</creator><creator>Murao, Masanobu</creator><creator>Miyasaka, Jyunsuke</creator><creator>Yoshida, Michiko</creator><creator>Nankaku, Manabu</creator><creator>Kanda, Junya</creator><creator>Takaori-Kondo, Akifumi</creator><creator>Ikeguchi, Ryosuke</creator><creator>Matsuda, Shuichi</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8959-6271</orcidid></search><sort><creationdate>20200701</creationdate><title>Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation</title><author>Hamada, Ryota ; Kondo, Tadakazu ; Murao, Masanobu ; Miyasaka, Jyunsuke ; Yoshida, Michiko ; Nankaku, Manabu ; Kanda, Junya ; Takaori-Kondo, Akifumi ; Ikeguchi, Ryosuke ; Matsuda, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-8783ca75c7116b8539664db5ac94442e6cb71dfe152940a52c989a0658fcac823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer therapies</topic><topic>Graft versus host disease</topic><topic>Hematopoietic stem cells</topic><topic>Knee</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mobility</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Palliative care</topic><topic>Rehabilitation Medicine</topic><topic>Side effects</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamada, Ryota</creatorcontrib><creatorcontrib>Kondo, Tadakazu</creatorcontrib><creatorcontrib>Murao, Masanobu</creatorcontrib><creatorcontrib>Miyasaka, Jyunsuke</creatorcontrib><creatorcontrib>Yoshida, Michiko</creatorcontrib><creatorcontrib>Nankaku, Manabu</creatorcontrib><creatorcontrib>Kanda, Junya</creatorcontrib><creatorcontrib>Takaori-Kondo, Akifumi</creatorcontrib><creatorcontrib>Ikeguchi, Ryosuke</creatorcontrib><creatorcontrib>Matsuda, Shuichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamada, Ryota</au><au>Kondo, Tadakazu</au><au>Murao, Masanobu</au><au>Miyasaka, Jyunsuke</au><au>Yoshida, Michiko</au><au>Nankaku, Manabu</au><au>Kanda, Junya</au><au>Takaori-Kondo, Akifumi</au><au>Ikeguchi, Ryosuke</au><au>Matsuda, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>28</volume><issue>7</issue><spage>3189</spage><epage>3196</epage><pages>3189-3196</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
The purpose of this study was to retrospectively investigate the effect of the severity of acute graft-versus-host disease (GVHD) on physical function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods
76 patients were included as subjects of this study. Severity of acute GVHD was classified according to the method defined by Grucksberg. To evaluate physical function, the knee extensor strength and six-minute walk distance (6MWD) were performed.
Results
Among these patients, 54% developed acute GVHD; of these, 32%, 54%, and 15% of patients had grade I, grade II, and grades III–IV GVHD, respectively. In the grade I–II groups, mild acute GVHD following allo-HSCT resulted in a gradual decline in physical function, which improved at discharge. However, in cases of severe acute GVHD, physical function deteriorated, implementation of rehabilitation became difficult, and the decline in physical function persisted even at discharge.
Conclusion
These results indicate that severe acute GVHD negatively affects physical function leading to longer hospital days because of inadequate rehabilitation interventions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31712955</pmid><doi>10.1007/s00520-019-05124-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8959-6271</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer therapies Graft versus host disease Hematopoietic stem cells Knee Medical colleges Medicine Medicine & Public Health Mobility Nursing Nursing Research Oncology Original Article Pain Medicine Palliative care Rehabilitation Medicine Side effects Stem cell transplantation Stem cells Transplantation Transplants & implants Walking |
| title | Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation |
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