Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren
Information on recurrent Clostridium difficile infections (rCDI) in children is rare and limited, especially community acquired (CA-CDI).This study was designed to identify risk factors for rCA-CDI in Serbian pediatric population. The study group included 71 children (aged from 1 to 14 years) with a...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2020-03, Vol.39 (3), p.509-516 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Predrag, Stojanovic Kuijper, Ed J. Nikola, Stojanović Vendrik, Karuna E. W. Niko, Radulović |
| description | Information on recurrent
Clostridium difficile
infections (rCDI) in children is rare and limited, especially community acquired (CA-CDI).This study was designed to identify risk factors for rCA-CDI in Serbian pediatric population. The study group included 71 children (aged from 1 to 14 years) with a first episode of CDI. Data were collected from 56 (78.87%) children with only one episode of CA-CDI and from 15 (21.13%) children with rCA-CDI were mutually compared. The following parameters were found to be statistically significantly more frequent in the children with rCA-CDI group (
p
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| doi_str_mv | 10.1007/s10096-019-03751-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2314009367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2314009367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-f5ec03aa858a3d0098e11727ce6431fa62c9dc97f2b5f77e1afcf7019434c31d3</originalsourceid><addsrcrecordid>eNp9kE1LJDEQhoMozuj6BzzIgBc9xE260p3uowzuKgiC6143ZJKKZugPTboP_nvLHT_Ag5ekQp73raqXsUMpzqQQ-mems6m4kA0XoEvJ1RabSwUlV6Bhm81FA4o3uoAZ28t5LUhUa73LZiC1BHrO2b9bdFNK2I8LN3Td1MfxmVv3NMWEfrFshzym6OPUnXzUQ_SYT30MIbrY4iL2Ad0Yh56qxR9Mq2h79xBbT64_2E6wbcaDt3uf_f11cbe85Nc3v6-W59fc0eAjDyU6AdbWZW3B01Y1SqkL7bBSIIOtCtd41-hQrMqgNUobXNC0uALlQHrYZycb38c0PE2YR9PF7LBtbY_DlE0BUpEtVJrQ4y_oephST9MRVRWyKURdE1VsKJeGnBMG85hiZ9OzkcK8pm826RsawvxP3ygSHb1ZT6sO_YfkPW4CYANk-urvMX32_sb2BYRYkPA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2362192088</pqid></control><display><type>article</type><title>Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren</title><source>SpringerLink Journals</source><creator>Predrag, Stojanovic ; Kuijper, Ed J. ; Nikola, Stojanović ; Vendrik, Karuna E. W. ; Niko, Radulović</creator><creatorcontrib>Predrag, Stojanovic ; Kuijper, Ed J. ; Nikola, Stojanović ; Vendrik, Karuna E. W. ; Niko, Radulović</creatorcontrib><description>Information on recurrent
Clostridium difficile
infections (rCDI) in children is rare and limited, especially community acquired (CA-CDI).This study was designed to identify risk factors for rCA-CDI in Serbian pediatric population. The study group included 71 children (aged from 1 to 14 years) with a first episode of CDI. Data were collected from 56 (78.87%) children with only one episode of CA-CDI and from 15 (21.13%) children with rCA-CDI were mutually compared. The following parameters were found to be statistically significantly more frequent in the children with rCA-CDI group (
p
< 0.05); leukemia as underlying disease, treatment with immunosuppressive and-or cytostatic drugs, and treatment with antibiotics. Similarly, previously visits to outpatient facilities, daycare hospitals and hospitals were also associated with rCDI. Analysis of clinical symptoms and laboratory parameters, revealed a statistically significant association of the severity of the first episode of CDI (determined by an increase in body temperature, higher maximum WBC and higher CRP) with development of a rCDI. Ribotype (RT) 027 was more common in children with rCA-CDI (66.7%,
p
= 0.006). During the seven-year research period, we found a rate of rCA-CDI rate in children of 21.13%. Our study identified several parameters statistically significantly more frequently in children with rCA-CDI. The obtained results will serve as a basis for future larger studies, but new prospective, studies are necessary to build a prediction model of rCDI in children that can be used to guide the treatment to prevent rCDI.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-019-03751-4</identifier><identifier>PMID: 31713000</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antibiotics ; Biomedical and Life Sciences ; Biomedicine ; Body temperature ; Children ; Daycare ; Hospitals ; Immunosuppressive agents ; Internal Medicine ; Leukemia ; Medical Microbiology ; Original Article ; Parameter identification ; Population studies ; Prediction models ; Recurrent infection ; Risk analysis ; Risk factors ; Signs and symptoms ; Statistical analysis</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2020-03, Vol.39 (3), p.509-516</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>European Journal of Clinical Microbiology and Infectious Diseases is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f5ec03aa858a3d0098e11727ce6431fa62c9dc97f2b5f77e1afcf7019434c31d3</citedby><cites>FETCH-LOGICAL-c375t-f5ec03aa858a3d0098e11727ce6431fa62c9dc97f2b5f77e1afcf7019434c31d3</cites><orcidid>0000-0001-7209-6660</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-019-03751-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-019-03751-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27904,27905,41468,42537,51299</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31713000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Predrag, Stojanovic</creatorcontrib><creatorcontrib>Kuijper, Ed J.</creatorcontrib><creatorcontrib>Nikola, Stojanović</creatorcontrib><creatorcontrib>Vendrik, Karuna E. W.</creatorcontrib><creatorcontrib>Niko, Radulović</creatorcontrib><title>Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Information on recurrent
Clostridium difficile
infections (rCDI) in children is rare and limited, especially community acquired (CA-CDI).This study was designed to identify risk factors for rCA-CDI in Serbian pediatric population. The study group included 71 children (aged from 1 to 14 years) with a first episode of CDI. Data were collected from 56 (78.87%) children with only one episode of CA-CDI and from 15 (21.13%) children with rCA-CDI were mutually compared. The following parameters were found to be statistically significantly more frequent in the children with rCA-CDI group (
p
< 0.05); leukemia as underlying disease, treatment with immunosuppressive and-or cytostatic drugs, and treatment with antibiotics. Similarly, previously visits to outpatient facilities, daycare hospitals and hospitals were also associated with rCDI. Analysis of clinical symptoms and laboratory parameters, revealed a statistically significant association of the severity of the first episode of CDI (determined by an increase in body temperature, higher maximum WBC and higher CRP) with development of a rCDI. Ribotype (RT) 027 was more common in children with rCA-CDI (66.7%,
p
= 0.006). During the seven-year research period, we found a rate of rCA-CDI rate in children of 21.13%. Our study identified several parameters statistically significantly more frequently in children with rCA-CDI. The obtained results will serve as a basis for future larger studies, but new prospective, studies are necessary to build a prediction model of rCDI in children that can be used to guide the treatment to prevent rCDI.</description><subject>Antibiotics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body temperature</subject><subject>Children</subject><subject>Daycare</subject><subject>Hospitals</subject><subject>Immunosuppressive agents</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Medical Microbiology</subject><subject>Original Article</subject><subject>Parameter identification</subject><subject>Population studies</subject><subject>Prediction models</subject><subject>Recurrent infection</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Signs and symptoms</subject><subject>Statistical analysis</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LJDEQhoMozuj6BzzIgBc9xE260p3uowzuKgiC6143ZJKKZugPTboP_nvLHT_Ag5ekQp73raqXsUMpzqQQ-mems6m4kA0XoEvJ1RabSwUlV6Bhm81FA4o3uoAZ28t5LUhUa73LZiC1BHrO2b9bdFNK2I8LN3Td1MfxmVv3NMWEfrFshzym6OPUnXzUQ_SYT30MIbrY4iL2Ad0Yh56qxR9Mq2h79xBbT64_2E6wbcaDt3uf_f11cbe85Nc3v6-W59fc0eAjDyU6AdbWZW3B01Y1SqkL7bBSIIOtCtd41-hQrMqgNUobXNC0uALlQHrYZycb38c0PE2YR9PF7LBtbY_DlE0BUpEtVJrQ4y_oephST9MRVRWyKURdE1VsKJeGnBMG85hiZ9OzkcK8pm826RsawvxP3ygSHb1ZT6sO_YfkPW4CYANk-urvMX32_sb2BYRYkPA</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Predrag, Stojanovic</creator><creator>Kuijper, Ed J.</creator><creator>Nikola, Stojanović</creator><creator>Vendrik, Karuna E. W.</creator><creator>Niko, Radulović</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7209-6660</orcidid></search><sort><creationdate>20200301</creationdate><title>Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren</title><author>Predrag, Stojanovic ; Kuijper, Ed J. ; Nikola, Stojanović ; Vendrik, Karuna E. W. ; Niko, Radulović</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-f5ec03aa858a3d0098e11727ce6431fa62c9dc97f2b5f77e1afcf7019434c31d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibiotics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body temperature</topic><topic>Children</topic><topic>Daycare</topic><topic>Hospitals</topic><topic>Immunosuppressive agents</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Medical Microbiology</topic><topic>Original Article</topic><topic>Parameter identification</topic><topic>Population studies</topic><topic>Prediction models</topic><topic>Recurrent infection</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Signs and symptoms</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Predrag, Stojanovic</creatorcontrib><creatorcontrib>Kuijper, Ed J.</creatorcontrib><creatorcontrib>Nikola, Stojanović</creatorcontrib><creatorcontrib>Vendrik, Karuna E. 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W.</au><au>Niko, Radulović</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>39</volume><issue>3</issue><spage>509</spage><epage>516</epage><pages>509-516</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Information on recurrent
Clostridium difficile
infections (rCDI) in children is rare and limited, especially community acquired (CA-CDI).This study was designed to identify risk factors for rCA-CDI in Serbian pediatric population. The study group included 71 children (aged from 1 to 14 years) with a first episode of CDI. Data were collected from 56 (78.87%) children with only one episode of CA-CDI and from 15 (21.13%) children with rCA-CDI were mutually compared. The following parameters were found to be statistically significantly more frequent in the children with rCA-CDI group (
p
< 0.05); leukemia as underlying disease, treatment with immunosuppressive and-or cytostatic drugs, and treatment with antibiotics. Similarly, previously visits to outpatient facilities, daycare hospitals and hospitals were also associated with rCDI. Analysis of clinical symptoms and laboratory parameters, revealed a statistically significant association of the severity of the first episode of CDI (determined by an increase in body temperature, higher maximum WBC and higher CRP) with development of a rCDI. Ribotype (RT) 027 was more common in children with rCA-CDI (66.7%,
p
= 0.006). During the seven-year research period, we found a rate of rCA-CDI rate in children of 21.13%. Our study identified several parameters statistically significantly more frequently in children with rCA-CDI. The obtained results will serve as a basis for future larger studies, but new prospective, studies are necessary to build a prediction model of rCDI in children that can be used to guide the treatment to prevent rCDI.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31713000</pmid><doi>10.1007/s10096-019-03751-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7209-6660</orcidid></addata></record> |
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| language | eng |
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| subjects | Antibiotics Biomedical and Life Sciences Biomedicine Body temperature Children Daycare Hospitals Immunosuppressive agents Internal Medicine Leukemia Medical Microbiology Original Article Parameter identification Population studies Prediction models Recurrent infection Risk analysis Risk factors Signs and symptoms Statistical analysis |
| title | Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren |
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