TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation
The Arabidopsis genome contains three genes encoding proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD-repeat (WDR) subfamily. TTG 1 is a known regulator of epidermal cell differentiation and pigment production, while LIGHT-REGULATED WD1 and LIGHT-REGULATED WD2 are known regulators of the circadi...
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| Veröffentlicht in: | Nature plants 2019-11, Vol.5 (11), p.1145-1153 |
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| creator | Airoldi, Chiara A. Hearn, Timothy J. Brockington, Samuel F. Webb, Alex A. R. Glover, Beverley J. |
| description | The
Arabidopsis
genome contains three genes encoding proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD-repeat (WDR) subfamily.
TTG
1
is a known regulator of epidermal cell differentiation and pigment production, while
LIGHT-REGULATED WD1
and
LIGHT-REGULATED WD2
are known regulators of the circadian clock. Here, we discovered a new central role for TTG1 WDR proteins as regulators of the circadian system, as evidenced by the lack of detectable circadian rhythms in a triple
lwd1
lwd2
ttg1
mutant. This shows that there has been subfunctionalization via protein changes within the angiosperms, with some TTG1 WDR proteins developing a stronger role in circadian clock regulation while losing the protein characteristics essential for pigment production and epidermal cell specification, and others weakening their ability to drive circadian clock regulation. Our work shows that even where proteins are very conserved, small changes can drive big functional differences.
Subfunctionalization allows gene paralogues to perform distinct ancestral functions. Now, Glover et al. report the functional divergence of proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD40-repeat family in
Arabidopsis
, showing that small changes in highly conserved proteins can result in major changes to their functions. |
| doi_str_mv | 10.1038/s41477-019-0544-3 |
| format | Article |
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Arabidopsis
genome contains three genes encoding proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD-repeat (WDR) subfamily.
TTG
1
is a known regulator of epidermal cell differentiation and pigment production, while
LIGHT-REGULATED WD1
and
LIGHT-REGULATED WD2
are known regulators of the circadian clock. Here, we discovered a new central role for TTG1 WDR proteins as regulators of the circadian system, as evidenced by the lack of detectable circadian rhythms in a triple
lwd1
lwd2
ttg1
mutant. This shows that there has been subfunctionalization via protein changes within the angiosperms, with some TTG1 WDR proteins developing a stronger role in circadian clock regulation while losing the protein characteristics essential for pigment production and epidermal cell specification, and others weakening their ability to drive circadian clock regulation. Our work shows that even where proteins are very conserved, small changes can drive big functional differences.
Subfunctionalization allows gene paralogues to perform distinct ancestral functions. Now, Glover et al. report the functional divergence of proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD40-repeat family in
Arabidopsis
, showing that small changes in highly conserved proteins can result in major changes to their functions.</description><identifier>ISSN: 2055-0278</identifier><identifier>EISSN: 2055-0278</identifier><identifier>DOI: 10.1038/s41477-019-0544-3</identifier><identifier>PMID: 31712761</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38 ; 631/181 ; 631/449 ; 631/449/2653 ; 631/80 ; 631/80/105 ; 82 ; 96 ; Arabidopsis - cytology ; Arabidopsis - physiology ; Arabidopsis Proteins - physiology ; Biomedical and Life Sciences ; Cell Differentiation ; Circadian rhythm ; Circadian rhythms ; Life Sciences ; Pigmentation ; Pigmentation - physiology ; Plant Cells - physiology ; Plant Epidermis - cytology ; Plant Sciences ; Proteins ; Regulation</subject><ispartof>Nature plants, 2019-11, Vol.5 (11), p.1145-1153</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2019</rights><rights>Copyright Nature Publishing Group Nov 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-329ef74bf126923b6cd844832fbf2bfd7f047587f0bf60064f5e07d239a95fb3</citedby><cites>FETCH-LOGICAL-c372t-329ef74bf126923b6cd844832fbf2bfd7f047587f0bf60064f5e07d239a95fb3</cites><orcidid>0000-0003-1216-219X ; 0000-0002-6393-819X ; 0000-0003-0261-4375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41477-019-0544-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41477-019-0544-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31712761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Airoldi, Chiara A.</creatorcontrib><creatorcontrib>Hearn, Timothy J.</creatorcontrib><creatorcontrib>Brockington, Samuel F.</creatorcontrib><creatorcontrib>Webb, Alex A. R.</creatorcontrib><creatorcontrib>Glover, Beverley J.</creatorcontrib><title>TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation</title><title>Nature plants</title><addtitle>Nat. Plants</addtitle><addtitle>Nat Plants</addtitle><description>The
Arabidopsis
genome contains three genes encoding proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD-repeat (WDR) subfamily.
TTG
1
is a known regulator of epidermal cell differentiation and pigment production, while
LIGHT-REGULATED WD1
and
LIGHT-REGULATED WD2
are known regulators of the circadian clock. Here, we discovered a new central role for TTG1 WDR proteins as regulators of the circadian system, as evidenced by the lack of detectable circadian rhythms in a triple
lwd1
lwd2
ttg1
mutant. This shows that there has been subfunctionalization via protein changes within the angiosperms, with some TTG1 WDR proteins developing a stronger role in circadian clock regulation while losing the protein characteristics essential for pigment production and epidermal cell specification, and others weakening their ability to drive circadian clock regulation. Our work shows that even where proteins are very conserved, small changes can drive big functional differences.
Subfunctionalization allows gene paralogues to perform distinct ancestral functions. Now, Glover et al. report the functional divergence of proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD40-repeat family in
Arabidopsis
, showing that small changes in highly conserved proteins can result in major changes to their functions.</description><subject>38</subject><subject>631/181</subject><subject>631/449</subject><subject>631/449/2653</subject><subject>631/80</subject><subject>631/80/105</subject><subject>82</subject><subject>96</subject><subject>Arabidopsis - cytology</subject><subject>Arabidopsis - physiology</subject><subject>Arabidopsis Proteins - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Differentiation</subject><subject>Circadian rhythm</subject><subject>Circadian rhythms</subject><subject>Life Sciences</subject><subject>Pigmentation</subject><subject>Pigmentation - physiology</subject><subject>Plant Cells - physiology</subject><subject>Plant Epidermis - cytology</subject><subject>Plant Sciences</subject><subject>Proteins</subject><subject>Regulation</subject><issn>2055-0278</issn><issn>2055-0278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtLxDAUhYMozjDOD3AjBTduqjevpl3KoKMw4KYbVyFtkyFDH2PSKvPvTen4QHB1QvKdc28OQpcYbjHQ9M4zzISIAWcxcMZieoLmBDiPgYj09Nd5hpbe7wAAC85pAudoRrHARCR4jl7zfI2jvet6bVsfOb0datXrqLSuVJVVbaTK3r7b_hApH33ouh5V722lXaPqqBxvzOhQbRXt7bbRba9627UX6Myo2uvlURcof3zIV0_x5mX9vLrfxCUVpI8pybQRrDCYJBmhRVJWKWMpJaYwpDCVMMAET4MUJgFImOEaREVopjJuCrpAN1Ns-MPboH0vG-vHrVSru8FLQjEDyEgmAnr9B911g2vDciNFRcLSlAQKT1TpOu-dNnLvbKPcQWKQY_Nyal6G5uXYvKTBc3VMHopGV9-Or54DQCbAh6d2q93P6P9TPwGMn4z8</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Airoldi, Chiara A.</creator><creator>Hearn, Timothy J.</creator><creator>Brockington, Samuel F.</creator><creator>Webb, Alex A. R.</creator><creator>Glover, Beverley J.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1216-219X</orcidid><orcidid>https://orcid.org/0000-0002-6393-819X</orcidid><orcidid>https://orcid.org/0000-0003-0261-4375</orcidid></search><sort><creationdate>20191101</creationdate><title>TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation</title><author>Airoldi, Chiara A. ; Hearn, Timothy J. ; Brockington, Samuel F. ; Webb, Alex A. 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R.</au><au>Glover, Beverley J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation</atitle><jtitle>Nature plants</jtitle><stitle>Nat. Plants</stitle><addtitle>Nat Plants</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>5</volume><issue>11</issue><spage>1145</spage><epage>1153</epage><pages>1145-1153</pages><issn>2055-0278</issn><eissn>2055-0278</eissn><abstract>The
Arabidopsis
genome contains three genes encoding proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD-repeat (WDR) subfamily.
TTG
1
is a known regulator of epidermal cell differentiation and pigment production, while
LIGHT-REGULATED WD1
and
LIGHT-REGULATED WD2
are known regulators of the circadian clock. Here, we discovered a new central role for TTG1 WDR proteins as regulators of the circadian system, as evidenced by the lack of detectable circadian rhythms in a triple
lwd1
lwd2
ttg1
mutant. This shows that there has been subfunctionalization via protein changes within the angiosperms, with some TTG1 WDR proteins developing a stronger role in circadian clock regulation while losing the protein characteristics essential for pigment production and epidermal cell specification, and others weakening their ability to drive circadian clock regulation. Our work shows that even where proteins are very conserved, small changes can drive big functional differences.
Subfunctionalization allows gene paralogues to perform distinct ancestral functions. Now, Glover et al. report the functional divergence of proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD40-repeat family in
Arabidopsis
, showing that small changes in highly conserved proteins can result in major changes to their functions.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31712761</pmid><doi>10.1038/s41477-019-0544-3</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1216-219X</orcidid><orcidid>https://orcid.org/0000-0002-6393-819X</orcidid><orcidid>https://orcid.org/0000-0003-0261-4375</orcidid></addata></record> |
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| subjects | 38 631/181 631/449 631/449/2653 631/80 631/80/105 82 96 Arabidopsis - cytology Arabidopsis - physiology Arabidopsis Proteins - physiology Biomedical and Life Sciences Cell Differentiation Circadian rhythm Circadian rhythms Life Sciences Pigmentation Pigmentation - physiology Plant Cells - physiology Plant Epidermis - cytology Plant Sciences Proteins Regulation |
| title | TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation |
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