Evolution of fungemia in an Italian region
Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy. Data on fungi responsible fo...
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| Veröffentlicht in: | Journal de mycologie médicale 2020-04, Vol.30 (1), p.100906-100906, Article 100906 |
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| creator | Prigitano, A. Cavanna, C. Passera, M. Gelmi, M. Sala, E. Ossi, C. Grancini, A. Calabrò, M. Bramati, S. Tejada, M. Lallitto, F. Farina, C. Rognoni, V. Fasano, M.A. Pini, B. Romanò, L. Cogliati, M. Esposto, M.C. Tortorano, A.M. |
| description | Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy.
Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed.
A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins |
| doi_str_mv | 10.1016/j.mycmed.2019.100906 |
| format | Article |
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Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed.
A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins<2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC.
No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.</description><identifier>ISSN: 1156-5233</identifier><identifier>EISSN: 1773-0449</identifier><identifier>DOI: 10.1016/j.mycmed.2019.100906</identifier><identifier>PMID: 31708424</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Antifungal resistance ; Candida ; Candidaemia ; Epidemiology ; Fungemia</subject><ispartof>Journal de mycologie médicale, 2020-04, Vol.30 (1), p.100906-100906, Article 100906</ispartof><rights>2019 Elsevier Masson SAS</rights><rights>Copyright © 2019 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-8618c8c7a52342b1d1a02fac5c0b9ba7df0b4e22ab04bacb2556755f928d99d63</citedby><cites>FETCH-LOGICAL-c362t-8618c8c7a52342b1d1a02fac5c0b9ba7df0b4e22ab04bacb2556755f928d99d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mycmed.2019.100906$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31708424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prigitano, A.</creatorcontrib><creatorcontrib>Cavanna, C.</creatorcontrib><creatorcontrib>Passera, M.</creatorcontrib><creatorcontrib>Gelmi, M.</creatorcontrib><creatorcontrib>Sala, E.</creatorcontrib><creatorcontrib>Ossi, C.</creatorcontrib><creatorcontrib>Grancini, A.</creatorcontrib><creatorcontrib>Calabrò, M.</creatorcontrib><creatorcontrib>Bramati, S.</creatorcontrib><creatorcontrib>Tejada, M.</creatorcontrib><creatorcontrib>Lallitto, F.</creatorcontrib><creatorcontrib>Farina, C.</creatorcontrib><creatorcontrib>Rognoni, V.</creatorcontrib><creatorcontrib>Fasano, M.A.</creatorcontrib><creatorcontrib>Pini, B.</creatorcontrib><creatorcontrib>Romanò, L.</creatorcontrib><creatorcontrib>Cogliati, M.</creatorcontrib><creatorcontrib>Esposto, M.C.</creatorcontrib><creatorcontrib>Tortorano, A.M.</creatorcontrib><title>Evolution of fungemia in an Italian region</title><title>Journal de mycologie médicale</title><addtitle>J Mycol Med</addtitle><description>Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy.
Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed.
A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins<2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC.
No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.</description><subject>Antifungal resistance</subject><subject>Candida</subject><subject>Candidaemia</subject><subject>Epidemiology</subject><subject>Fungemia</subject><issn>1156-5233</issn><issn>1773-0449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobk7_gUgvRejMd5sbQcbUwcAbvQ5Jmo6MtplJO9i_N6Xz1qsTTp5zXs4DwD2CSwQRf94v25NpbbXEEInUggLyCzBHRUFySKm4TG_EeM4wITNwE-MeQsYZo9dgRlABS4rpHDytj74Zeue7zNdZPXQ72zqVuS5TXbbpVeNSDXaXgFtwVasm2rtzXYDvt_XX6iPffr5vVq_b3BCO-7zkqDSlKVQKplijCimIa2WYgVpoVVQ11NRirDSkWhmNGeMFY7XAZSVExckCPE57D8H_DDb2snXR2KZRnfVDlJggwlOIGFE6oSb4GIOt5SG4VoWTRFCOluReTpbkaElOltLYwzlh0OPf39CflgS8TIBNdx6dDTIaZztjKxes6WXl3f8Jv6x-eKw</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Prigitano, A.</creator><creator>Cavanna, C.</creator><creator>Passera, M.</creator><creator>Gelmi, M.</creator><creator>Sala, E.</creator><creator>Ossi, C.</creator><creator>Grancini, A.</creator><creator>Calabrò, M.</creator><creator>Bramati, S.</creator><creator>Tejada, M.</creator><creator>Lallitto, F.</creator><creator>Farina, C.</creator><creator>Rognoni, V.</creator><creator>Fasano, M.A.</creator><creator>Pini, B.</creator><creator>Romanò, L.</creator><creator>Cogliati, M.</creator><creator>Esposto, M.C.</creator><creator>Tortorano, A.M.</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Evolution of fungemia in an Italian region</title><author>Prigitano, A. ; Cavanna, C. ; Passera, M. ; Gelmi, M. ; Sala, E. ; Ossi, C. ; Grancini, A. ; Calabrò, M. ; Bramati, S. ; Tejada, M. ; Lallitto, F. ; Farina, C. ; Rognoni, V. ; Fasano, M.A. ; Pini, B. ; Romanò, L. ; Cogliati, M. ; Esposto, M.C. ; Tortorano, A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-8618c8c7a52342b1d1a02fac5c0b9ba7df0b4e22ab04bacb2556755f928d99d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antifungal resistance</topic><topic>Candida</topic><topic>Candidaemia</topic><topic>Epidemiology</topic><topic>Fungemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prigitano, A.</creatorcontrib><creatorcontrib>Cavanna, C.</creatorcontrib><creatorcontrib>Passera, M.</creatorcontrib><creatorcontrib>Gelmi, M.</creatorcontrib><creatorcontrib>Sala, E.</creatorcontrib><creatorcontrib>Ossi, C.</creatorcontrib><creatorcontrib>Grancini, A.</creatorcontrib><creatorcontrib>Calabrò, M.</creatorcontrib><creatorcontrib>Bramati, S.</creatorcontrib><creatorcontrib>Tejada, M.</creatorcontrib><creatorcontrib>Lallitto, F.</creatorcontrib><creatorcontrib>Farina, C.</creatorcontrib><creatorcontrib>Rognoni, V.</creatorcontrib><creatorcontrib>Fasano, M.A.</creatorcontrib><creatorcontrib>Pini, B.</creatorcontrib><creatorcontrib>Romanò, L.</creatorcontrib><creatorcontrib>Cogliati, M.</creatorcontrib><creatorcontrib>Esposto, M.C.</creatorcontrib><creatorcontrib>Tortorano, A.M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal de mycologie médicale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prigitano, A.</au><au>Cavanna, C.</au><au>Passera, M.</au><au>Gelmi, M.</au><au>Sala, E.</au><au>Ossi, C.</au><au>Grancini, A.</au><au>Calabrò, M.</au><au>Bramati, S.</au><au>Tejada, M.</au><au>Lallitto, F.</au><au>Farina, C.</au><au>Rognoni, V.</au><au>Fasano, M.A.</au><au>Pini, B.</au><au>Romanò, L.</au><au>Cogliati, M.</au><au>Esposto, M.C.</au><au>Tortorano, A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of fungemia in an Italian region</atitle><jtitle>Journal de mycologie médicale</jtitle><addtitle>J Mycol Med</addtitle><date>2020-04</date><risdate>2020</risdate><volume>30</volume><issue>1</issue><spage>100906</spage><epage>100906</epage><pages>100906-100906</pages><artnum>100906</artnum><issn>1156-5233</issn><eissn>1773-0449</eissn><abstract>Fungemia represents a public health concern. Knowing aetiology and activity of the antifungals is critical for the management of bloodstream infections. Therefore, surveillance on local/international levels is desirable for a prompt administration of appropriate therapy.
Data on fungi responsible for fungemia and antifungal susceptibility profiles were collected from a laboratory-based surveillance over 2016–2017 in 12 hospitals located in Lombardia, Italy. The trend of this infection in twenty years was analysed.
A total of 1024 episodes were evaluated. Rate of candiaemia progressively increased up to 1.46/1000 admissions. C.albicans was the most common species (52%), followed by C. parapsilosis (15%) and C glabrata (13%). As in the previous surveys the antifungal resistance is rare (echinocandins<2%, fluconazole 6%, amphotericin B 0.6%). Fungi other than Candida were responsible for 18 episodes: Cryptococcus neoformans (5 cases), Fusarium spp. (4), Magnusiomyces clavatus (3), Saccharomyces cerevisiae (3), Rhodotorula spp. (2), Exophiala dermatitidis (1). All fungi, except S.cerevisiae, were intrinsically resistant to echinocandins. Some isolates showed also elevated azole MIC.
No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>31708424</pmid><doi>10.1016/j.mycmed.2019.100906</doi><tpages>1</tpages></addata></record> |
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| subjects | Antifungal resistance Candida Candidaemia Epidemiology Fungemia |
| title | Evolution of fungemia in an Italian region |
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