In Vivo Reflectance Confocal Microscopy of Gold Microparticles Deposited in the Skin. A Case Report on Cutaneous Chrysiasis
Cutaneous chrysiasis is gold deposition in the dermis, described after parenteral administration of gold salts or after topical exposure to gold‐containing materials. Gold microparticles (GMPs) have versatile therapeutic effects and are increasingly used in medicine. This case report describes the d...
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| Veröffentlicht in: | Lasers in surgery and medicine 2020-01, Vol.52 (1), p.13-16 |
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| creator | Fuchs, Christine S.K. Ardigo, Marco Haedersdal, Merete Mogensen, Mette |
| description | Cutaneous chrysiasis is gold deposition in the dermis, described after parenteral administration of gold salts or after topical exposure to gold‐containing materials. Gold microparticles (GMPs) have versatile therapeutic effects and are increasingly used in medicine. This case report describes the development of a blue‐gray macule following the facial application of GMPs and laser treatment of acne vulgaris. Dermoscopy showed a nonspecific homogenous blue‐gray pattern, gradually fading over an 8‐month‐period. Reflectance confocal microscopy (RCM) detected hyperreflective, subcellular particles in the papillary dermis, localized around hair follicles, eccrine glands, and inside macrophages. Histopathological evaluation, darkfield illumination with hyperspectral imaging, and neutron activation analysis confirmed the presence of GMPs in the dermis. RCM allowed non‐invasive fast visualization of aggregates of hyperreflective particles in the dermis and can potentially be used for monitoring localized cutaneous chrysiasis and other metal deposition conditions over time. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/lsm.23179 |
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Reflectance confocal microscopy (RCM) detected hyperreflective, subcellular particles in the papillary dermis, localized around hair follicles, eccrine glands, and inside macrophages. Histopathological evaluation, darkfield illumination with hyperspectral imaging, and neutron activation analysis confirmed the presence of GMPs in the dermis. RCM allowed non‐invasive fast visualization of aggregates of hyperreflective particles in the dermis and can potentially be used for monitoring localized cutaneous chrysiasis and other metal deposition conditions over time. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.23179</identifier><identifier>PMID: 31709601</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Acne ; acne vulgaris ; Activation analysis ; Case reports ; Cell activation ; Chrysiasis ; Confocal microscopy ; Deposition ; Dermis ; Follicles ; Glands ; Gold ; gold microparticles ; Hyperspectral imaging ; laser treatment ; Lasers ; localized chrysiasis ; Macrophages ; Microparticles ; Microscopes ; Microscopy ; Neutron activation analysis ; Neutrons ; Pollutant deposition ; Reflectance ; reflectance confocal microscopy ; Salts</subject><ispartof>Lasers in surgery and medicine, 2020-01, Vol.52 (1), p.13-16</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-471fe2f0fab84ed72e3a553a0b5dead361df56b8d19a0c706b28897fda2de93a3</citedby><cites>FETCH-LOGICAL-c3539-471fe2f0fab84ed72e3a553a0b5dead361df56b8d19a0c706b28897fda2de93a3</cites><orcidid>0000-0003-3329-2516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.23179$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.23179$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31709601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuchs, Christine S.K.</creatorcontrib><creatorcontrib>Ardigo, Marco</creatorcontrib><creatorcontrib>Haedersdal, Merete</creatorcontrib><creatorcontrib>Mogensen, Mette</creatorcontrib><title>In Vivo Reflectance Confocal Microscopy of Gold Microparticles Deposited in the Skin. A Case Report on Cutaneous Chrysiasis</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg Med</addtitle><description>Cutaneous chrysiasis is gold deposition in the dermis, described after parenteral administration of gold salts or after topical exposure to gold‐containing materials. Gold microparticles (GMPs) have versatile therapeutic effects and are increasingly used in medicine. This case report describes the development of a blue‐gray macule following the facial application of GMPs and laser treatment of acne vulgaris. Dermoscopy showed a nonspecific homogenous blue‐gray pattern, gradually fading over an 8‐month‐period. Reflectance confocal microscopy (RCM) detected hyperreflective, subcellular particles in the papillary dermis, localized around hair follicles, eccrine glands, and inside macrophages. Histopathological evaluation, darkfield illumination with hyperspectral imaging, and neutron activation analysis confirmed the presence of GMPs in the dermis. RCM allowed non‐invasive fast visualization of aggregates of hyperreflective particles in the dermis and can potentially be used for monitoring localized cutaneous chrysiasis and other metal deposition conditions over time. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.</description><subject>Acne</subject><subject>acne vulgaris</subject><subject>Activation analysis</subject><subject>Case reports</subject><subject>Cell activation</subject><subject>Chrysiasis</subject><subject>Confocal microscopy</subject><subject>Deposition</subject><subject>Dermis</subject><subject>Follicles</subject><subject>Glands</subject><subject>Gold</subject><subject>gold microparticles</subject><subject>Hyperspectral imaging</subject><subject>laser treatment</subject><subject>Lasers</subject><subject>localized chrysiasis</subject><subject>Macrophages</subject><subject>Microparticles</subject><subject>Microscopes</subject><subject>Microscopy</subject><subject>Neutron activation analysis</subject><subject>Neutrons</subject><subject>Pollutant deposition</subject><subject>Reflectance</subject><subject>reflectance confocal microscopy</subject><subject>Salts</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp10UFLHDEUB_BQKnW1PfQLlEAv9bDry2RnMjnKtFVhRdC21yGTvGBsdjJNZpTFL9_YUQ8FT3mEH38e70_IRwYrBlAc-7RdFZwJ-YYsGMhqKRmwt2QBLM81yGKfHKR0CwC8APGO7GebGbAFeTjv6S93F-gVWo96VL1G2oTeBq08vXA6hqTDsKPB0tPgzfw1qDg67THRrziE5EY01PV0vEF6_dv1K3pCG5Uwhw4hjjT0tJlyNIYp0eYm7pJTyaX3ZM8qn_DD03tIfn7_9qM5W24uT8-bk81S85LL5Vowi4UFq7p6jUYUyFVZcgVdaVAZXjFjy6qrDZMKtICqK-paCmtUYVByxQ_Jlzl3iOHPhGlsty5p9H7eqM2n41Up1muR6ef_6G2YYp-3y4rLUnCoWFZHs3q8Topo2yG6rYq7lkH72EibG2n_NZLtp6fEqduieZHPFWRwPIN753H3elK7ub6YI_8CvIuVfw</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Fuchs, Christine S.K.</creator><creator>Ardigo, Marco</creator><creator>Haedersdal, Merete</creator><creator>Mogensen, Mette</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3329-2516</orcidid></search><sort><creationdate>202001</creationdate><title>In Vivo Reflectance Confocal Microscopy of Gold Microparticles Deposited in the Skin. A Case Report on Cutaneous Chrysiasis</title><author>Fuchs, Christine S.K. ; Ardigo, Marco ; Haedersdal, Merete ; Mogensen, Mette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-471fe2f0fab84ed72e3a553a0b5dead361df56b8d19a0c706b28897fda2de93a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acne</topic><topic>acne vulgaris</topic><topic>Activation analysis</topic><topic>Case reports</topic><topic>Cell activation</topic><topic>Chrysiasis</topic><topic>Confocal microscopy</topic><topic>Deposition</topic><topic>Dermis</topic><topic>Follicles</topic><topic>Glands</topic><topic>Gold</topic><topic>gold microparticles</topic><topic>Hyperspectral imaging</topic><topic>laser treatment</topic><topic>Lasers</topic><topic>localized chrysiasis</topic><topic>Macrophages</topic><topic>Microparticles</topic><topic>Microscopes</topic><topic>Microscopy</topic><topic>Neutron activation analysis</topic><topic>Neutrons</topic><topic>Pollutant deposition</topic><topic>Reflectance</topic><topic>reflectance confocal microscopy</topic><topic>Salts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuchs, Christine S.K.</creatorcontrib><creatorcontrib>Ardigo, Marco</creatorcontrib><creatorcontrib>Haedersdal, Merete</creatorcontrib><creatorcontrib>Mogensen, Mette</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuchs, Christine S.K.</au><au>Ardigo, Marco</au><au>Haedersdal, Merete</au><au>Mogensen, Mette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Reflectance Confocal Microscopy of Gold Microparticles Deposited in the Skin. A Case Report on Cutaneous Chrysiasis</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg Med</addtitle><date>2020-01</date><risdate>2020</risdate><volume>52</volume><issue>1</issue><spage>13</spage><epage>16</epage><pages>13-16</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><abstract>Cutaneous chrysiasis is gold deposition in the dermis, described after parenteral administration of gold salts or after topical exposure to gold‐containing materials. Gold microparticles (GMPs) have versatile therapeutic effects and are increasingly used in medicine. This case report describes the development of a blue‐gray macule following the facial application of GMPs and laser treatment of acne vulgaris. Dermoscopy showed a nonspecific homogenous blue‐gray pattern, gradually fading over an 8‐month‐period. Reflectance confocal microscopy (RCM) detected hyperreflective, subcellular particles in the papillary dermis, localized around hair follicles, eccrine glands, and inside macrophages. Histopathological evaluation, darkfield illumination with hyperspectral imaging, and neutron activation analysis confirmed the presence of GMPs in the dermis. RCM allowed non‐invasive fast visualization of aggregates of hyperreflective particles in the dermis and can potentially be used for monitoring localized cutaneous chrysiasis and other metal deposition conditions over time. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31709601</pmid><doi>10.1002/lsm.23179</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-3329-2516</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Acne acne vulgaris Activation analysis Case reports Cell activation Chrysiasis Confocal microscopy Deposition Dermis Follicles Glands Gold gold microparticles Hyperspectral imaging laser treatment Lasers localized chrysiasis Macrophages Microparticles Microscopes Microscopy Neutron activation analysis Neutrons Pollutant deposition Reflectance reflectance confocal microscopy Salts |
| title | In Vivo Reflectance Confocal Microscopy of Gold Microparticles Deposited in the Skin. A Case Report on Cutaneous Chrysiasis |
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