Doxorubicin-doxorubicin conjugate prodrug as drug self-delivery system for intracellular pH-triggered slow release

[Display omitted] •D-DOXcar with drug content of 86% was designed for pH-triggered slow drug release.•It exhibited particle size- and concentration-dependent slow DOX release.•It showed similar tumor inhibition free from carboxylesterases (CES).•It possessed an enhanced anti-tumor efficacy in compar...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2020-01, Vol.185, p.110608-110608, Article 110608
Hauptverfasser:	Li, Jiagen, Li, Xinming, Liu, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-triggered Carbamate linker Doxorubicin Drug self-delivery system Drug-drug conjugate Slow drug release
Online-Zugang:	Volltext
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