Predictive value of abdominal aortic calcification index for mid-term cardiovascular events in patients with acute coronary syndrome

The utility of abdominal aortic calcification (AAC) for prediction of cardiovascular events (CVEs) in patients with acute coronary syndrome (ACS) remains to be determined. The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a sem...

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Veröffentlicht in:Heart and vessels 2020-05, Vol.35 (5), p.620-629
Hauptverfasser: Oishi, Hideo, Horibe, Hideki, Yamase, Yuichiro, Ueyama, Chikara, Takemoto, Yoshio, Shigeta, Toshimasa, Hibino, Takeshi, Kondo, Taizo, Suzuki, Susumu, Ishii, Hideki, Murohara, Toyoaki
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container_end_page 629
container_issue 5
container_start_page 620
container_title Heart and vessels
container_volume 35
creator Oishi, Hideo
Horibe, Hideki
Yamase, Yuichiro
Ueyama, Chikara
Takemoto, Yoshio
Shigeta, Toshimasa
Hibino, Takeshi
Kondo, Taizo
Suzuki, Susumu
Ishii, Hideki
Murohara, Toyoaki
description The utility of abdominal aortic calcification (AAC) for prediction of cardiovascular events (CVEs) in patients with acute coronary syndrome (ACS) remains to be determined. The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a semi-quantitative measure of AAC, for CVEs in patients with ACS. We evaluated 314 patients with ACS. All patients underwent successful percutaneous coronary intervention to the culprit coronary vessel without in-hospital adverse events. ACI was calculated on non-contrast computed tomography images. CVEs were defined as a composite of cardiovascular death, ACS recurrence, and stroke. During a median follow-up period of 19.1 months, CVEs occurred in 29 patients (9.2%). Multivariable regression analysis after adjustment for age and gender showed a significantly higher baseline ACI in patients with CVEs than in those without [median (interquartile ranges), 42.1 (25.9–60.2) vs. 20.8 (8.8–38.6) %; P  = 0.021]. The cutoff value of ACI for prediction of CVEs, estimated by receiver-operating characteristic analysis, was 29.2%, with sensitivity of 76% and specificity of 64% (area under the curve, 0.69). After adjustment for conventional cardiovascular risk factors, Cox analysis showed high ACI (≥29.2%) to be significantly associated with increased risk of CVEs ( P  = 0.011; hazard ratio, 1.82). Multivariate analysis identified high ACI as an independent predictor of CVEs ( P  = 0.012; hazard ratio, 1.80). Stepwise forward selection procedure also showed that high ACI was a significant independent determinant of CVEs ( P  = 0.004; R 2 , 0.089). Both net reclassification improvement (0.64; P  = 0.001) and integrated discrimination improvement (0.04; P  
doi_str_mv 10.1007/s00380-019-01527-6
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The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a semi-quantitative measure of AAC, for CVEs in patients with ACS. We evaluated 314 patients with ACS. All patients underwent successful percutaneous coronary intervention to the culprit coronary vessel without in-hospital adverse events. ACI was calculated on non-contrast computed tomography images. CVEs were defined as a composite of cardiovascular death, ACS recurrence, and stroke. During a median follow-up period of 19.1 months, CVEs occurred in 29 patients (9.2%). Multivariable regression analysis after adjustment for age and gender showed a significantly higher baseline ACI in patients with CVEs than in those without [median (interquartile ranges), 42.1 (25.9–60.2) vs. 20.8 (8.8–38.6) %; P  = 0.021]. The cutoff value of ACI for prediction of CVEs, estimated by receiver-operating characteristic analysis, was 29.2%, with sensitivity of 76% and specificity of 64% (area under the curve, 0.69). After adjustment for conventional cardiovascular risk factors, Cox analysis showed high ACI (≥29.2%) to be significantly associated with increased risk of CVEs ( P  = 0.011; hazard ratio, 1.82). Multivariate analysis identified high ACI as an independent predictor of CVEs ( P  = 0.012; hazard ratio, 1.80). Stepwise forward selection procedure also showed that high ACI was a significant independent determinant of CVEs ( P  = 0.004; R 2 , 0.089). Both net reclassification improvement (0.64; P  = 0.001) and integrated discrimination improvement (0.04; P  &lt; 0.001) improved significantly after the addition of high ACI to conventional risk factors. 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The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a semi-quantitative measure of AAC, for CVEs in patients with ACS. We evaluated 314 patients with ACS. All patients underwent successful percutaneous coronary intervention to the culprit coronary vessel without in-hospital adverse events. ACI was calculated on non-contrast computed tomography images. CVEs were defined as a composite of cardiovascular death, ACS recurrence, and stroke. During a median follow-up period of 19.1 months, CVEs occurred in 29 patients (9.2%). Multivariable regression analysis after adjustment for age and gender showed a significantly higher baseline ACI in patients with CVEs than in those without [median (interquartile ranges), 42.1 (25.9–60.2) vs. 20.8 (8.8–38.6) %; P  = 0.021]. The cutoff value of ACI for prediction of CVEs, estimated by receiver-operating characteristic analysis, was 29.2%, with sensitivity of 76% and specificity of 64% (area under the curve, 0.69). After adjustment for conventional cardiovascular risk factors, Cox analysis showed high ACI (≥29.2%) to be significantly associated with increased risk of CVEs ( P  = 0.011; hazard ratio, 1.82). Multivariate analysis identified high ACI as an independent predictor of CVEs ( P  = 0.012; hazard ratio, 1.80). Stepwise forward selection procedure also showed that high ACI was a significant independent determinant of CVEs ( P  = 0.004; R 2 , 0.089). Both net reclassification improvement (0.64; P  = 0.001) and integrated discrimination improvement (0.04; P  &lt; 0.001) improved significantly after the addition of high ACI to conventional risk factors. Evaluation of ACI using CT seems to provide valuable clinical information for proper assessment of mid-term CVEs in patients with ACS after percutaneous coronary intervention.</description><subject>Abdomen</subject><subject>Acute Coronary Syndrome - diagnostic imaging</subject><subject>Acute Coronary Syndrome - mortality</subject><subject>Acute Coronary Syndrome - therapy</subject><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty</subject><subject>Aorta</subject><subject>Aorta, Abdominal - diagnostic imaging</subject><subject>Aortic Diseases - diagnostic imaging</subject><subject>Aortic Diseases - mortality</subject><subject>Aortography</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Blood vessels</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Computed tomography</subject><subject>Computed Tomography Angiography</subject><subject>Evaluation</subject><subject>Female</subject><subject>Health hazards</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Image contrast</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Original Article</subject><subject>Patients</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - mortality</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Reclassification</subject><subject>Recurrence</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Stroke - mortality</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vascular Calcification - diagnostic imaging</subject><subject>Vascular Calcification - mortality</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFCEURonROO3oC7gwJG7clEJRBcXSTMafZBJd6Jpc4KJMqooWqNbZ--DS06MmLlwQSDjfdwOHkKecveSMqVeFMTGxjnHd1tirTt4jOy752PWjEvfJjmnOukn06ow8KuWaNUpz_ZCcCa6YGrnckZ8fM_roajwgPcC8IU2BgvVpiSvMFFKu0VEHs4shOqgxrTSuHn_QkDJdou8q5qUB2cd0gOK2GTLFA661NJDuW-T2_D3WrxTcVpG6lNMK-YaWm9XntOBj8iDAXPDJ3X5OPr-5_HTxrrv68Pb9xeurzgmtayc9n5gDJtFqHwIOVnJvfdBCT9ZyOYKWAAGEssJa1WuG0nk7-kFINYIS5-TFqXef07cNSzVLLA7nGVZMWzG94EIOWo9TQ5__g16nLbcvOVKT1MOg-yPVnyiXUykZg9nnuLSnGc7M0ZE5OTLNkbl1ZGQLPbur3uyC_k_kt5QGiBNQ2tX6BfPf2f-p_QViUJ_a</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Oishi, Hideo</creator><creator>Horibe, Hideki</creator><creator>Yamase, Yuichiro</creator><creator>Ueyama, Chikara</creator><creator>Takemoto, Yoshio</creator><creator>Shigeta, Toshimasa</creator><creator>Hibino, Takeshi</creator><creator>Kondo, Taizo</creator><creator>Suzuki, Susumu</creator><creator>Ishii, Hideki</creator><creator>Murohara, Toyoaki</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20200501</creationdate><title>Predictive value of abdominal aortic calcification index for mid-term cardiovascular events in patients with acute coronary syndrome</title><author>Oishi, Hideo ; Horibe, Hideki ; Yamase, Yuichiro ; Ueyama, Chikara ; Takemoto, Yoshio ; Shigeta, Toshimasa ; Hibino, Takeshi ; Kondo, Taizo ; Suzuki, Susumu ; Ishii, Hideki ; Murohara, Toyoaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-6d180ca06eb9dffe4b61dbdf9398bb165a96aafa37b3bb7290e6cdb5d43675a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Acute Coronary Syndrome - diagnostic imaging</topic><topic>Acute Coronary Syndrome - mortality</topic><topic>Acute Coronary Syndrome - therapy</topic><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angioplasty</topic><topic>Aorta</topic><topic>Aorta, Abdominal - diagnostic imaging</topic><topic>Aortic Diseases - diagnostic imaging</topic><topic>Aortic Diseases - mortality</topic><topic>Aortography</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Blood vessels</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Computed tomography</topic><topic>Computed Tomography Angiography</topic><topic>Evaluation</topic><topic>Female</topic><topic>Health hazards</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Image contrast</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Original Article</topic><topic>Patients</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Reclassification</topic><topic>Recurrence</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Stroke - mortality</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vascular Calcification - diagnostic imaging</topic><topic>Vascular Calcification - mortality</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oishi, Hideo</creatorcontrib><creatorcontrib>Horibe, Hideki</creatorcontrib><creatorcontrib>Yamase, Yuichiro</creatorcontrib><creatorcontrib>Ueyama, Chikara</creatorcontrib><creatorcontrib>Takemoto, Yoshio</creatorcontrib><creatorcontrib>Shigeta, Toshimasa</creatorcontrib><creatorcontrib>Hibino, Takeshi</creatorcontrib><creatorcontrib>Kondo, Taizo</creatorcontrib><creatorcontrib>Suzuki, Susumu</creatorcontrib><creatorcontrib>Ishii, Hideki</creatorcontrib><creatorcontrib>Murohara, Toyoaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oishi, Hideo</au><au>Horibe, Hideki</au><au>Yamase, Yuichiro</au><au>Ueyama, Chikara</au><au>Takemoto, Yoshio</au><au>Shigeta, Toshimasa</au><au>Hibino, Takeshi</au><au>Kondo, Taizo</au><au>Suzuki, Susumu</au><au>Ishii, Hideki</au><au>Murohara, Toyoaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of abdominal aortic calcification index for mid-term cardiovascular events in patients with acute coronary syndrome</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>35</volume><issue>5</issue><spage>620</spage><epage>629</epage><pages>620-629</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>The utility of abdominal aortic calcification (AAC) for prediction of cardiovascular events (CVEs) in patients with acute coronary syndrome (ACS) remains to be determined. The aim of this prospective study was to determine the predictive value of the abdominal aortic calcification index (ACI), a semi-quantitative measure of AAC, for CVEs in patients with ACS. We evaluated 314 patients with ACS. All patients underwent successful percutaneous coronary intervention to the culprit coronary vessel without in-hospital adverse events. ACI was calculated on non-contrast computed tomography images. CVEs were defined as a composite of cardiovascular death, ACS recurrence, and stroke. During a median follow-up period of 19.1 months, CVEs occurred in 29 patients (9.2%). Multivariable regression analysis after adjustment for age and gender showed a significantly higher baseline ACI in patients with CVEs than in those without [median (interquartile ranges), 42.1 (25.9–60.2) vs. 20.8 (8.8–38.6) %; P  = 0.021]. The cutoff value of ACI for prediction of CVEs, estimated by receiver-operating characteristic analysis, was 29.2%, with sensitivity of 76% and specificity of 64% (area under the curve, 0.69). After adjustment for conventional cardiovascular risk factors, Cox analysis showed high ACI (≥29.2%) to be significantly associated with increased risk of CVEs ( P  = 0.011; hazard ratio, 1.82). Multivariate analysis identified high ACI as an independent predictor of CVEs ( P  = 0.012; hazard ratio, 1.80). Stepwise forward selection procedure also showed that high ACI was a significant independent determinant of CVEs ( P  = 0.004; R 2 , 0.089). Both net reclassification improvement (0.64; P  = 0.001) and integrated discrimination improvement (0.04; P  &lt; 0.001) improved significantly after the addition of high ACI to conventional risk factors. Evaluation of ACI using CT seems to provide valuable clinical information for proper assessment of mid-term CVEs in patients with ACS after percutaneous coronary intervention.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>31707516</pmid><doi>10.1007/s00380-019-01527-6</doi><tpages>10</tpages></addata></record>
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subjects Abdomen
Acute Coronary Syndrome - diagnostic imaging
Acute Coronary Syndrome - mortality
Acute Coronary Syndrome - therapy
Acute coronary syndromes
Aged
Aged, 80 and over
Angioplasty
Aorta
Aorta, Abdominal - diagnostic imaging
Aortic Diseases - diagnostic imaging
Aortic Diseases - mortality
Aortography
Biomedical Engineering and Bioengineering
Blood vessels
Calcification
Calcification (ectopic)
Cardiac Surgery
Cardiology
Cardiovascular diseases
Computed tomography
Computed Tomography Angiography
Evaluation
Female
Health hazards
Health risk assessment
Health risks
Humans
Image contrast
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Original Article
Patients
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - mortality
Predictive Value of Tests
Prospective Studies
Reclassification
Recurrence
Regression analysis
Risk analysis
Risk Assessment
Risk Factors
Severity of Illness Index
Stroke - mortality
Time Factors
Treatment Outcome
Vascular Calcification - diagnostic imaging
Vascular Calcification - mortality
Vascular Surgery
title Predictive value of abdominal aortic calcification index for mid-term cardiovascular events in patients with acute coronary syndrome
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