HLA-E-restricted CD8 + T Lymphocytes Efficiently Control Mycobacterium tuberculosis and HIV-1 Coinfection

We investigated the contribution of human leukocyte antigen A2 (HLA-A2) and HLA-E-restricted CD8 T cells in patients with and human immunodeficiency virus 1 (HIV-1) coinfection. HIV-1 downregulates HLA-A, -B, and -C molecules in infected cells, thus influencing recognition by HLA class I-restricted...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2020-04, Vol.62 (4), p.430-439
Hauptverfasser:	La Manna, Marco Pio, Orlando, Valentina, Prezzemolo, Teresa, Di Carlo, Paola, Cascio, Antonio, Delogu, Giovanni, Poli, Guido, Sullivan, Lucy C, Brooks, Andrew G, Dieli, Francesco, Caccamo, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Antigens, Bacterial - immunology Antiretroviral drugs CD8 antigen CD8-Positive T-Lymphocytes - immunology Coinfection - immunology Down-Regulation - immunology Female Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology HIV HIV Infections - immunology HIV-1 - immunology HLA-A2 Antigen - immunology HLA-E Antigens Human immunodeficiency virus Humans Lymphocyte Activation - immunology Lymphocyte Count - methods Lymphocytes Lymphocytes T Male Middle Aged Monoclonal antibodies Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology PD-1 protein Phenotypes Tuberculosis Tuberculosis - immunology
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