Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization
The activation of toll‐like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchable Pam3CSK4 derivative—P10—to control the activati...
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2020-04, Vol.21 (8), p.1150-1154 |
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| container_title | Chembiochem : a European journal of chemical biology |
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| creator | Hu, Hong‐Guo Chen, Pu‐Guang Wang, Guanyu Wu, Jun‐Jun Zhang, Bo‐Dou Li, Wen‐Hao Davis, Rebecca L. Li, Yan‐Mei |
| description | The activation of toll‐like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchable Pam3CSK4 derivative—P10—to control the activation of TLR1/2. The ground‐state trans‐P10 was able to stimulate and activate antigen‐presenting cells (APCs) by promoting TLR1/2 heterodimerization. However, cis‐P10, derived from UV irradiation of trans‐P10, reduced the activities of APCs by impeding the TLR1/2 heterodimerization. In the absence of UV radiation, the cis‐P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulation. Our results indicated that optical control of TLR1/2 heterodimerization mediated by the photoswitchable P10 offers the potential to regulate immune activation and inflammation.
Reduction of systemic inflammation without immune system inhibition: A photoswitchable ligand for regulation of immune activation through optical control of the heterodimerization of toll‐like receptors 1 and 2 (TLR1/2) has been developed, offering the potential to regulate immune activation and inflammation. |
| doi_str_mv | 10.1002/cbic.201900591 |
| format | Article |
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Reduction of systemic inflammation without immune system inhibition: A photoswitchable ligand for regulation of immune activation through optical control of the heterodimerization of toll‐like receptors 1 and 2 (TLR1/2) has been developed, offering the potential to regulate immune activation and inflammation.</description><identifier>ISSN: 1439-4227</identifier><identifier>EISSN: 1439-7633</identifier><identifier>DOI: 10.1002/cbic.201900591</identifier><identifier>PMID: 31702879</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Activation ; Antigen-presenting cells ; Antigens ; azobenzenes ; dimerization ; Immune response ; Immune system ; immunochemistry ; Irradiation ; Optical control ; photoswitching ; Proteins ; Stability ; TLR1 protein ; TLR1/2 ; Toll-like receptors ; Ultraviolet radiation</subject><ispartof>Chembiochem : a European journal of chemical biology, 2020-04, Vol.21 (8), p.1150-1154</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4101-8d9d0b5bba5fdc694dc4fec3ddb1bd53d7e1b0dffb7ad87e8c1b8337318aca2d3</citedby><cites>FETCH-LOGICAL-c4101-8d9d0b5bba5fdc694dc4fec3ddb1bd53d7e1b0dffb7ad87e8c1b8337318aca2d3</cites><orcidid>0000-0003-1215-5010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbic.201900591$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbic.201900591$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31702879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Hong‐Guo</creatorcontrib><creatorcontrib>Chen, Pu‐Guang</creatorcontrib><creatorcontrib>Wang, Guanyu</creatorcontrib><creatorcontrib>Wu, Jun‐Jun</creatorcontrib><creatorcontrib>Zhang, Bo‐Dou</creatorcontrib><creatorcontrib>Li, Wen‐Hao</creatorcontrib><creatorcontrib>Davis, Rebecca L.</creatorcontrib><creatorcontrib>Li, Yan‐Mei</creatorcontrib><title>Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization</title><title>Chembiochem : a European journal of chemical biology</title><addtitle>Chembiochem</addtitle><description>The activation of toll‐like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchable Pam3CSK4 derivative—P10—to control the activation of TLR1/2. The ground‐state trans‐P10 was able to stimulate and activate antigen‐presenting cells (APCs) by promoting TLR1/2 heterodimerization. However, cis‐P10, derived from UV irradiation of trans‐P10, reduced the activities of APCs by impeding the TLR1/2 heterodimerization. In the absence of UV radiation, the cis‐P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulation. Our results indicated that optical control of TLR1/2 heterodimerization mediated by the photoswitchable P10 offers the potential to regulate immune activation and inflammation.
Reduction of systemic inflammation without immune system inhibition: A photoswitchable ligand for regulation of immune activation through optical control of the heterodimerization of toll‐like receptors 1 and 2 (TLR1/2) has been developed, offering the potential to regulate immune activation and inflammation.</description><subject>Activation</subject><subject>Antigen-presenting cells</subject><subject>Antigens</subject><subject>azobenzenes</subject><subject>dimerization</subject><subject>Immune response</subject><subject>Immune system</subject><subject>immunochemistry</subject><subject>Irradiation</subject><subject>Optical control</subject><subject>photoswitching</subject><subject>Proteins</subject><subject>Stability</subject><subject>TLR1 protein</subject><subject>TLR1/2</subject><subject>Toll-like receptors</subject><subject>Ultraviolet radiation</subject><issn>1439-4227</issn><issn>1439-7633</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqF0M9LwzAUB_AgipvTq0cpePHSmde0TXOcRd1gMBjzXPKrktE2M22V-dfb2jnBi6c8wud9eXwRugY8BYyDeymMnAYYGMYRgxM0hpAwn8aEnB7mMAjoCF3U9RZjzGIC52hEgOIgoWyMVmv92ha8MbbybO4tyrKttDeTjXkfPsXeW-0aI3nhpbZqnC16t1mu4T7w5rrRzipTamc-v_0lOst5UeurwztBL0-Pm3TuL1fPi3S29GUIGPxEMYVFJASPciVjFioZ5loSpQQIFRFFNQis8lxQrhKqEwkiIYQSSLjkgSITdDfk7px9a3XdZKWppS4KXmnb1llAgJAYkjju6O0furWtq7rrOsUIYwlEvZoOSjpb107n2c6Zkrt9Bjjrq876qrNj1d3CzSG2FaVWR_7TbQfYAD5Moff_xGXpwyL9Df8C2IOK5A</recordid><startdate>20200417</startdate><enddate>20200417</enddate><creator>Hu, Hong‐Guo</creator><creator>Chen, Pu‐Guang</creator><creator>Wang, Guanyu</creator><creator>Wu, Jun‐Jun</creator><creator>Zhang, Bo‐Dou</creator><creator>Li, Wen‐Hao</creator><creator>Davis, Rebecca L.</creator><creator>Li, Yan‐Mei</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1215-5010</orcidid></search><sort><creationdate>20200417</creationdate><title>Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization</title><author>Hu, Hong‐Guo ; 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The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchable Pam3CSK4 derivative—P10—to control the activation of TLR1/2. The ground‐state trans‐P10 was able to stimulate and activate antigen‐presenting cells (APCs) by promoting TLR1/2 heterodimerization. However, cis‐P10, derived from UV irradiation of trans‐P10, reduced the activities of APCs by impeding the TLR1/2 heterodimerization. In the absence of UV radiation, the cis‐P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulation. Our results indicated that optical control of TLR1/2 heterodimerization mediated by the photoswitchable P10 offers the potential to regulate immune activation and inflammation.
Reduction of systemic inflammation without immune system inhibition: A photoswitchable ligand for regulation of immune activation through optical control of the heterodimerization of toll‐like receptors 1 and 2 (TLR1/2) has been developed, offering the potential to regulate immune activation and inflammation.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31702879</pmid><doi>10.1002/cbic.201900591</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1215-5010</orcidid></addata></record> |
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| subjects | Activation Antigen-presenting cells Antigens azobenzenes dimerization Immune response Immune system immunochemistry Irradiation Optical control photoswitching Proteins Stability TLR1 protein TLR1/2 Toll-like receptors Ultraviolet radiation |
| title | Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization |
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