Targeted blocking of miR328 lysosomal degradation with alkalized exosomes sensitizes the chronic leukemia cells to imatinib

Imatinib resistance remains the biggest hurdle for the treatment of chronic myeloid leukemia (CML), with the underlying mechanisms not fully understood. In this study, we found that miR328 significantly and strikingly decreased among other miRNA candidates during the induction of imatinib resistance...

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Veröffentlicht in:	Applied microbiology and biotechnology 2019-12, Vol.103 (23-24), p.9569-9582
Hauptverfasser:	Dong, Yan, Lin, Yao, Gao, Xiaotong, Zhao, Yingxin, Wan, Zhuo, Wang, Haotian, Wei, Mengying, Chen, Xutao, Qin, Weiwei, Yang, Guodong, Liu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkalies - pharmacology Alkalizing Antineoplastic Agents - pharmacology Apoptosis - drug effects Applied Genetics and Molecular Biotechnology Biomedical and Life Sciences Biotechnology Care and treatment Cell Line, Tumor Chloroquine Chronic myeloid leukemia Down-Regulation Drug delivery systems Drug resistance Exosomes Exosomes - chemistry HEK293 Cells Humans Imatinib Imatinib Mesylate - pharmacology Inhibitor drugs K562 Cells Leukemia Life Sciences Lysosomes Lysosomes - drug effects Lysosomes - metabolism Microbial Genetics and Genomics Microbiology MicroRNA MicroRNAs - antagonists & inhibitors MicroRNAs - genetics miRNA Myeloid leukemia Post-transcription Targeted cancer therapy
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