Novel glycosylated human interferon alpha 2b expressed in glycoengineered Pichia pastoris and its biological activity: N-linked glycoengineering approach

[Display omitted] •N-glycoengineering approach for the design of novel glycosylated human IFN α2b.•Successful human-like N-glycosylated IFN α2b expression by glycoengineered P. pastoris.•Improved plasma half-life of purified glycosylated human IFN α2b.•Glycosylated human IFN α2b is biologically acti...

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Veröffentlicht in:	Enzyme and microbial technology 2019-09, Vol.128, p.49-58
Hauptverfasser:	Katla, Srikanth, Yoganand, K.N.R., Hingane, Smita, Ranjith Kumar, C.T., Anand, B., Sivaprakasam, Senthilkumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Glycoengineering Interferon alpha 2b N-glycosylation P. pastoris
Online-Zugang:	Volltext
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