Specific stimulation of T lymphocytes with erythropoietin for adoptive immunotherapy

In adoptive T-cell immunotherapy of cancer, expansion and persistence of effector cells is a key determinant of response. We tested whether T lymphocytes could be rendered sensitive to erythropoietin (Epo) through ectopic expression of its wild-type receptor or a truncated form (EpoRm), which augmen...

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Veröffentlicht in:	Blood 2020-02, Vol.135 (9), p.668-679
Hauptverfasser:	Vinanica, Natasha, Yong, Arthur, Wong, Desmond, Png, Yi Tian, Seow, See Voon, Imamura, Masaru, Campana, Dario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Erythropoietin - immunology Humans Immunotherapy, Adoptive - methods Mice Mice, Inbred NOD Mice, SCID Receptors, Chimeric Antigen - immunology Receptors, Erythropoietin - immunology T-Lymphocytes - immunology Xenograft Model Antitumor Assays
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