Keratinocytes apoptosis contributes to crizotinib induced-erythroderma

[Display omitted] •Crizotinib induces apoptosis of human keratinocytes directly.•Crizotinib induces human keratinocytes apoptosis through caspase-dependent way.•The extrinsic pathway is responsible for crizotinib-induced apoptosis.•The apoptosis independent of mitochondrial dysfunction, DNA damage a...

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Veröffentlicht in:	Toxicology letters 2020-02, Vol.319, p.102-110
Hauptverfasser:	Hu, Yuhuai, Zhang, Xiaochen, Zhao, Ziying, Chen, Xueqin, Zhou, Ziye, Yang, Xiaochun, Yang, Bo, He, Qiaojun, Luo, Peihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Caspase 8 - metabolism Caspase Inhibitors - pharmacology Cell Line Cleaved-caspase-8 Crizotinib Crizotinib - toxicity Cutaneous toxicity Dermatitis, Exfoliative - chemically induced Dermatitis, Exfoliative - pathology DNA Damage Erythroderma Humans Keratinocytes - drug effects Membrane Potential, Mitochondrial - drug effects Primary Cell Culture Reactive Oxygen Species - metabolism Signal Transduction - drug effects
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