Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke

To investigate the molecular, structural, and functional impact of aerosols from candidate modified risk tobacco products (cMRTP), the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of mainstream cigarette smoke (CS) on the cardiovascular system of...

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Veröffentlicht in:	Chemico-biological interactions 2020-01, Vol.315, p.108887, Article 108887
Hauptverfasser:	Szostak, Justyna, Titz, Bjoern, Schlage, Walter K., Guedj, Emmanuel, Sewer, Alain, Phillips, Blaine, Leroy, Patrice, Buettner, Ansgar, Neau, Laurent, Trivedi, Keyur, Martin, Florian, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols - adverse effects Ahr Animals Aorta, Thoracic - drug effects ApoE-/- mice Apolipoproteins E - metabolism Atherosclerosis Atherosclerosis - metabolism Candidate modified-risk tobacco products Carbon - adverse effects Cardiovascular System - drug effects Cardiovascular System - metabolism Cigarette smoke Female Heart ventricle dysfunction Heating - adverse effects Inhalation Exposure - adverse effects Lung - drug effects Lung - metabolism Mice Smoke - adverse effects Smoking - adverse effects Tobacco Products - adverse effects Transcriptome - drug effects Xenobiotic metabolism
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