Adenovirus vectors in hematopoietic stem cell genome editing

Genome editing of hematopoietic stem cells (HSCs) represents a therapeutic option for a number of hematological genetic diseases, as HSCs have the potential for self‐renewal and differentiation into all blood cell lineages. This review presents advances of genome editing in HSCs utilizing adenovirus...

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Veröffentlicht in:	FEBS letters 2019-12, Vol.593 (24), p.3623-3648
Hauptverfasser:	Li, Chang, Lieber, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics adenovirus vector Animals base editors CRISPR/Cas9 Gene Editing - methods Genetic Vectors - genetics Genetic Vectors - pharmacology genome editing Helper Viruses - physiology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - chemistry Hematopoietic Stem Cells - drug effects HSCs Humans in vivo transduction Mice targeted integration
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