SUMOylation homeostasis in tumorigenesis
Small ubiquitin-like modifier (SUMO), a critical regulatory modification protein, is involved in various biological processes, such as gene expression, genome maintenance and DNA damage repair (DDR). Numerous recent studies have revealed that disturbed SUMOylation and deSUMOylation homeostasis contr...
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| Veröffentlicht in: | Cancer letters 2020-01, Vol.469, p.301-309 |
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| container_title | Cancer letters |
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| creator | Xie, Minyue Yu, Jie Ge, Shengfang Huang, Jian Fan, Xianqun |
| description | Small ubiquitin-like modifier (SUMO), a critical regulatory modification protein, is involved in various biological processes, such as gene expression, genome maintenance and DNA damage repair (DDR). Numerous recent studies have revealed that disturbed SUMOylation and deSUMOylation homeostasis contribute to tumorigenesis. Abnormal alterations of key factors in the SUMO modification are closely related to cancer development and progression, indicating that the restoration of SUMOylation homeostasis may serve as a promising therapeutic strategy. In this review, we summarize the process and function of SUMOylation, clarify the ‘dual-edged sword’ functions of SUMOylation in diversified cancers and put forth future research prospects.
•We summarized the research progress and impacts of SUMOylation homeostasis in tumorigenesis.•We provided an overview of the mechanism of aberrant SUMOylation involved in cancer regulation and progression..•We expounded the clinical need and potential therapeutic targets of aberrant SUMOylated proteins in cancers. |
| doi_str_mv | 10.1016/j.canlet.2019.11.004 |
| format | Article |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Breast cancer Cell cycle Colorectal cancer Deoxyribonucleic acid DNA DNA damage DNA repair Enzymes Gene expression Genomes Homeostasis Kinases Leukemia Liver cancer Localization Maintenance Prostate cancer Proteins SUMO protein SUMOylation Tumorigenesis Ubiquitin |
| title | SUMOylation homeostasis in tumorigenesis |
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