Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair
Nucleotide excision repair (NER) is one of the major DNA repair pathways aimed at maintaining genome stability. Correction of DNA damage by the NER system is a multistage process that proceeds with the formation of multiple DNA-protein and protein-protein intermediate complexes and requires precise...
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| Veröffentlicht in: | Biochemistry (Moscow) 2019-09, Vol.84 (9), p.1008-1020 |
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| creator | Rechkunova, N. I. Maltseva, E. A. Lavrik, O. I. |
| description | Nucleotide excision repair (NER) is one of the major DNA repair pathways aimed at maintaining genome stability. Correction of DNA damage by the NER system is a multistage process that proceeds with the formation of multiple DNA-protein and protein-protein intermediate complexes and requires precise coordination and regulation. NER proteins undergo post-translational modifications, such as ubiquitination, sumoylation, phosphorylation, acetylation, and poly(ADP-ribosyl)ation. These modifications affect the interaction of NER factors with DNA and other proteins and thus regulate either their recruitment into the complexes or dissociation from these complexes at certain stages of DNA repair, as well as modulate the functional activity of NER proteins and control the process of DNA repair in general. Here, we review the data on the post-translational modifications of NER factors and their effects on DNA repair. Protein poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 and its impact on NER are discussed in detail, since such analysis has not been done before. |
| doi_str_mv | 10.1134/S0006297919090037 |
| format | Article |
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Here, we review the data on the post-translational modifications of NER factors and their effects on DNA repair. Protein poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 and its impact on NER are discussed in detail, since such analysis has not been done before.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297919090037</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Acetylation ; Adenosine diphosphate ; ADP-ribosylation ; Analysis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Coordination compounds ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA repair ; Excision (Surgery) ; Genomes ; Life Sciences ; Methods ; Microbiology ; Nucleotide excision repair ; Nucleotides ; Phosphorylation ; Poly(ADP-ribose) ; Poly(ADP-ribose) polymerase ; Post-translation ; Post-translational modification ; Protein biosynthesis ; Proteins ; Repair ; Review ; Ribose ; SUMO protein ; Translation ; Ubiquitination</subject><ispartof>Biochemistry (Moscow), 2019-09, Vol.84 (9), p.1008-1020</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Biochemistry (Moscow) is a copyright of Springer, (2019). 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I.</creatorcontrib><title>Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><description>Nucleotide excision repair (NER) is one of the major DNA repair pathways aimed at maintaining genome stability. Correction of DNA damage by the NER system is a multistage process that proceeds with the formation of multiple DNA-protein and protein-protein intermediate complexes and requires precise coordination and regulation. NER proteins undergo post-translational modifications, such as ubiquitination, sumoylation, phosphorylation, acetylation, and poly(ADP-ribosyl)ation. These modifications affect the interaction of NER factors with DNA and other proteins and thus regulate either their recruitment into the complexes or dissociation from these complexes at certain stages of DNA repair, as well as modulate the functional activity of NER proteins and control the process of DNA repair in general. Here, we review the data on the post-translational modifications of NER factors and their effects on DNA repair. Protein poly(ADP-ribosyl)ation catalyzed by poly(ADP-ribose) polymerase 1 and its impact on NER are discussed in detail, since such analysis has not been done before.</description><subject>Acetylation</subject><subject>Adenosine diphosphate</subject><subject>ADP-ribosylation</subject><subject>Analysis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Coordination compounds</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA repair</subject><subject>Excision (Surgery)</subject><subject>Genomes</subject><subject>Life Sciences</subject><subject>Methods</subject><subject>Microbiology</subject><subject>Nucleotide excision repair</subject><subject>Nucleotides</subject><subject>Phosphorylation</subject><subject>Poly(ADP-ribose)</subject><subject>Poly(ADP-ribose) polymerase</subject><subject>Post-translation</subject><subject>Post-translational modification</subject><subject>Protein biosynthesis</subject><subject>Proteins</subject><subject>Repair</subject><subject>Review</subject><subject>Ribose</subject><subject>SUMO protein</subject><subject>Translation</subject><subject>Ubiquitination</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUlPwzAQhS0EEqXwA7hZ4sIlZWwncXys2KWyiOUcuc6kNUrjYqcS_HscilSxyQdr3nzvaTRDyCGDEWMiPXkEgJwrqZgCBSDkFhmwHIpEQArbZNC3k76_S_ZCeIklByUGZH7vQpd0Xreh0Z11rW7ojatsbc1nGair6e3KNOg6WyE9fzM2RJ0-4FJbT--969BGTLcVfZpjlB5cg9S2tJsjPbsdf5H7ZKfWTcCDr39Ini_On06vksnd5fXpeJKYlOVdolEzXoDgmdamriRiDdl0mvJCgDRQpVKpVBuhQbEs5ZDlSkkUTOdTPq2MEENyvM5deve6wtCVCxsMNo1u0a1CyUWfLwueRfToB_riVj5uIFK8UIIDY3xDzXSDpW1rF7dl-tBynAOXLJeZitToDyq-ChfWuBZrG_VvBrY2GO9C8FiXS28X2r-XDMr-pOWvk0YPX3tCZNsZ-s3A_5s-AM3HoCA</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Rechkunova, N. 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| subjects | Acetylation Adenosine diphosphate ADP-ribosylation Analysis Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Coordination compounds Deoxyribonucleic acid DNA DNA damage DNA repair Excision (Surgery) Genomes Life Sciences Methods Microbiology Nucleotide excision repair Nucleotides Phosphorylation Poly(ADP-ribose) Poly(ADP-ribose) polymerase Post-translation Post-translational modification Protein biosynthesis Proteins Repair Review Ribose SUMO protein Translation Ubiquitination |
| title | Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair |
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