In Vivo Solid‐Phase Microextraction for Sampling of Oxylipins in Brain of Awake, Moving Rats

Oxylipins are key lipid mediators of important brain processes, including pain, sleep, oxidative stress, and inflammation. For the first time, an in‐depth profile of up to 52 oxylipins can be obtained from the brains of awake moving animals using in vivo solid‐phase microextraction (SPME) chemical b...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-02, Vol.59 (6), p.2392-2398
Hauptverfasser:	Napylov, Alexander, Reyes‐Garces, Nathaly, Gomez‐Rios, German, Olkowicz, Mariola, Lendor, Sofia, Monnin, Cian, Bojko, Barbara, Hamani, Clement, Pawliszyn, Janusz, Vuckovic, Dajana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy Brain Brain - metabolism Chromatography, High Pressure Liquid Cluster Analysis High resolution inflammation in vivo microextraction Lipids Liquid chromatography Mass spectrometry Mass spectroscopy Microdialysis Nervous system Organic chemistry Oxidative stress Oxylipins - analysis Oxylipins - chemistry Oxylipins - isolation & purification Pain prostaglandins Rats Sleep Solid phase methods Solid Phase Microextraction Spatial discrimination Spatial resolution Tandem Mass Spectrometry Wakefulness
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