An update on potentials and promises of T cell co‐signaling molecules in transplantation

The promising outcomes of immune‐checkpoint based immunotherapies in cancer have provided a proportional perspective ahead of exploiting similar approaches in allotransplantation. Belatacept (CTLA‐4‐Ig) is an example of costimulation blockers successfully exploited in renal transplantation. Due to t...

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Veröffentlicht in:	Journal of cellular physiology 2020-05, Vol.235 (5), p.4183-4197
Hauptverfasser:	Mardomi, Alireza, Mohammadi, Nabiallah, Khosroshahi, Hamid Tayebi, Abediankenari, Saeid
Format:	Artikel
Sprache:	eng
Schlagworte:	allograft Animal models Animals Antibodies Antigens, CD - metabolism CD28 antigen CD40 antigen CD40L protein CD80 antigen checkpoint molecule CTLA‐4 Humans Immune Checkpoint Inhibitors - therapeutic use Immune response Immune system Immunoglobulins Immunological tolerance Immunomodulation Immunomodulators Immunotherapy Kidney transplantation Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Organ Transplantation - methods PD-L1 protein PD‐1/PD‐L1 Signal Transduction - drug effects Signaling T-Lymphocytes - drug effects T-Lymphocytes - physiology Transplantation
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