TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR‐glycolysis signaling axis

Aberrant expression of the tripartite motif containing 59 (TRIM59) has been reported to participate in the development and progression of various human cancers. However, its expression pattern and cellular roles in pancreatic cancer (PC) remains unclear. In our study, we found that TRIM59 expression...

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Veröffentlicht in:	Journal of cellular biochemistry 2020-02, Vol.121 (2), p.1986-1997
Hauptverfasser:	Li, Rongkun, Weng, Li, Liu, Bingyan, Zhu, Lili, Zhang, Xiaoxin, Tian, Guangang, Hu, Lipeng, Li, Qing, Jiang, Shuheng, Shang, Mingyi
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Bioinformatics Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cell growth Cell migration Cell Movement Cell Proliferation Depletion Female Gene Expression Regulation, Neoplastic Glycolysis Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Medical prognosis Metastases metastasis Mice Mice, Nude Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT/mTOR pathway Prognosis proliferation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal transduction Signaling siRNA Survival Rate TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism tripartite motif containing 59 Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays
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