Algorithm-Based Liquid Formulation Development Including a DoE Concept Predicts Long-Term Viral Vector Stability

Specifically tailored amino acid–based formulations were previously shown to have a high potential to avoid stress-mediated degradation of complex molecules such as monoclonal antibodies and viral vectors. By using adenovirus 5 (Ad5) as a model, we studied whether such formulations may also efficien...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2020-01, Vol.109 (1), p.818-829
Hauptverfasser:	Reinauer, Eva B., Grosso, Stella S., Henz, Stefan R., Rabas, Julia A., Rodenstein, Carina, Altrichter, Jens, Scholz, Martin, Kemter, Kristina F.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenoviral vectors Adenoviruses, Human - genetics Algorithms Amino Acids - chemistry design of experiments DNA, Viral - chemistry DNA, Viral - metabolism excipient(s) Excipients - chemistry formulation(s) gene delivery Gene Transfer Techniques Genetic Vectors HEK293 Cells Humans Nucleic Acid Denaturation stabilization Temperature Time Factors vaccine(s) viral vector(s)
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