Thermosensitive molecularly imprinted poly(1‐vinyl‐2‐pyrrolidone/methyl methacrylate/N‐vinylcaprolactam) for selective extraction of imatinib mesylate in human biological fluid
The efficiency of a molecularly imprinted polymer as a selective packing material for the solid‐phase extraction of imatinib mesylate sorption was investigated. The molecularly imprinted polymer was prepared using N,N′‐methylenebisacrylamide as a cross‐linker agent, N‐vinylcaprolactam as a thermo‐se...
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| Veröffentlicht in: | Journal of separation science 2020-02, Vol.43 (3), p.614-621 |
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| creator | Kazemi, Atefeh Ahmad Panahi, Homayon Safaeijavan, Raheleh |
| description | The efficiency of a molecularly imprinted polymer as a selective packing material for the solid‐phase extraction of imatinib mesylate sorption was investigated. The molecularly imprinted polymer was prepared using N,N′‐methylenebisacrylamide as a cross‐linker agent, N‐vinylcaprolactam as a thermo‐sensitive monomer, 1‐vinyl‐2‐pyrrolidone and methyl methacrylate as functional monomers, azobisisobutyronitrile as an initiator and imatinib mesylate as a template. The drug‐imprinted polymer was identified by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. It was found that this polymer can be used for determination of trace levels of imatinib mesylate with a recovery percentage that could reach over 90%. Furthermore, the synthesized molecularly imprinted polymer indicated higher selectivity towards imatinib mesylate than other compounds. From isotherm study, the equilibrium adsorption data of imatinib mesylate by imprinted polymer were analyzed by Langmuir, Freundlich, and Temkin isotherm models. The developed method was used for determination of imatinib mesylate in human fluid samples by high performance liquid chromatography with excellent results. |
| doi_str_mv | 10.1002/jssc.201900535 |
| format | Article |
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The molecularly imprinted polymer was prepared using N,N′‐methylenebisacrylamide as a cross‐linker agent, N‐vinylcaprolactam as a thermo‐sensitive monomer, 1‐vinyl‐2‐pyrrolidone and methyl methacrylate as functional monomers, azobisisobutyronitrile as an initiator and imatinib mesylate as a template. The drug‐imprinted polymer was identified by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. It was found that this polymer can be used for determination of trace levels of imatinib mesylate with a recovery percentage that could reach over 90%. Furthermore, the synthesized molecularly imprinted polymer indicated higher selectivity towards imatinib mesylate than other compounds. From isotherm study, the equilibrium adsorption data of imatinib mesylate by imprinted polymer were analyzed by Langmuir, Freundlich, and Temkin isotherm models. The developed method was used for determination of imatinib mesylate in human fluid samples by high performance liquid chromatography with excellent results.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201900535</identifier><identifier>PMID: 31691505</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Azobisisobutyronitrile ; Fourier transforms ; High performance liquid chromatography ; human biological fluids ; imatinib mesylate ; Imprinted polymers ; Infrared analysis ; Inhibitor drugs ; Isotherms ; Methylene bisacrylamide ; molecularly imprinted polymer ; Monomers ; Polymers ; Polymethyl methacrylate ; selective extraction ; Selectivity ; Thermogravimetric analysis ; thermosensitive polymer</subject><ispartof>Journal of separation science, 2020-02, Vol.43 (3), p.614-621</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 WILEY‐VCH Verlag GmbH & Co. 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The molecularly imprinted polymer was prepared using N,N′‐methylenebisacrylamide as a cross‐linker agent, N‐vinylcaprolactam as a thermo‐sensitive monomer, 1‐vinyl‐2‐pyrrolidone and methyl methacrylate as functional monomers, azobisisobutyronitrile as an initiator and imatinib mesylate as a template. The drug‐imprinted polymer was identified by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. It was found that this polymer can be used for determination of trace levels of imatinib mesylate with a recovery percentage that could reach over 90%. Furthermore, the synthesized molecularly imprinted polymer indicated higher selectivity towards imatinib mesylate than other compounds. From isotherm study, the equilibrium adsorption data of imatinib mesylate by imprinted polymer were analyzed by Langmuir, Freundlich, and Temkin isotherm models. The developed method was used for determination of imatinib mesylate in human fluid samples by high performance liquid chromatography with excellent results.</description><subject>Azobisisobutyronitrile</subject><subject>Fourier transforms</subject><subject>High performance liquid chromatography</subject><subject>human biological fluids</subject><subject>imatinib mesylate</subject><subject>Imprinted polymers</subject><subject>Infrared analysis</subject><subject>Inhibitor drugs</subject><subject>Isotherms</subject><subject>Methylene bisacrylamide</subject><subject>molecularly imprinted polymer</subject><subject>Monomers</subject><subject>Polymers</subject><subject>Polymethyl methacrylate</subject><subject>selective extraction</subject><subject>Selectivity</subject><subject>Thermogravimetric analysis</subject><subject>thermosensitive polymer</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkb1uFDEUhS0EIiHQUiJLNKHY3WvPeH5KtOJXERQJ9cj23GG98s9izwSmyyPkcXgengRvNtmChsI6lvz5nGsfQl4yWDIAvtqmpJccWAsgCvGInLKKiUVbsPLxcQ_VCXmW0haA1U0LT8lJwaqWCRCn5PfVBqMLCX0yo7lG6oJFPVkZ7UyN20XjR-zpLtj5nP25ub02frZZeV67OcZgTR88rhyOm9nSvUgdZytHXH154LXcZVDqUbo3dAiRJswhd3H4a4z5wARPw5AD5Wi8Udkn3XlQ4-lmctJTZYIN342Wlg52Mv1z8mSQNuGLez0j396_u1p_XFx8_fBp_fZioUsQ9UKJATSvC96KmmEjywElcgZCSOCFkEK1vBZYQV81mUWuxcAVKK6k4Io3xRk5P_jmJ_yYMI2dM0mjtdJjmFLHC8aFgKbYo6__Qbdhij5PlynBc11lCZlaHigdQ0oRhy5_spNx7hh0-067fafdsdN84dW97aQc9kf8ocQMlAfgp7E4_8eu-3x5ua6qsi7-AikMtjU</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Kazemi, Atefeh</creator><creator>Ahmad Panahi, Homayon</creator><creator>Safaeijavan, Raheleh</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5041-8059</orcidid></search><sort><creationdate>202002</creationdate><title>Thermosensitive molecularly imprinted poly(1‐vinyl‐2‐pyrrolidone/methyl methacrylate/N‐vinylcaprolactam) for selective extraction of imatinib mesylate in human biological fluid</title><author>Kazemi, Atefeh ; Ahmad Panahi, Homayon ; Safaeijavan, Raheleh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4057-b5f0c27329571e8a4feae21055a0235a5b9275e60d68b5fe2c5f2b0b2ba52b283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Azobisisobutyronitrile</topic><topic>Fourier transforms</topic><topic>High performance liquid chromatography</topic><topic>human biological fluids</topic><topic>imatinib mesylate</topic><topic>Imprinted polymers</topic><topic>Infrared analysis</topic><topic>Inhibitor drugs</topic><topic>Isotherms</topic><topic>Methylene bisacrylamide</topic><topic>molecularly imprinted polymer</topic><topic>Monomers</topic><topic>Polymers</topic><topic>Polymethyl methacrylate</topic><topic>selective extraction</topic><topic>Selectivity</topic><topic>Thermogravimetric analysis</topic><topic>thermosensitive polymer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazemi, Atefeh</creatorcontrib><creatorcontrib>Ahmad Panahi, Homayon</creatorcontrib><creatorcontrib>Safaeijavan, Raheleh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazemi, Atefeh</au><au>Ahmad Panahi, Homayon</au><au>Safaeijavan, Raheleh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermosensitive molecularly imprinted poly(1‐vinyl‐2‐pyrrolidone/methyl methacrylate/N‐vinylcaprolactam) for selective extraction of imatinib mesylate in human biological fluid</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2020-02</date><risdate>2020</risdate><volume>43</volume><issue>3</issue><spage>614</spage><epage>621</epage><pages>614-621</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>The efficiency of a molecularly imprinted polymer as a selective packing material for the solid‐phase extraction of imatinib mesylate sorption was investigated. The molecularly imprinted polymer was prepared using N,N′‐methylenebisacrylamide as a cross‐linker agent, N‐vinylcaprolactam as a thermo‐sensitive monomer, 1‐vinyl‐2‐pyrrolidone and methyl methacrylate as functional monomers, azobisisobutyronitrile as an initiator and imatinib mesylate as a template. The drug‐imprinted polymer was identified by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. It was found that this polymer can be used for determination of trace levels of imatinib mesylate with a recovery percentage that could reach over 90%. Furthermore, the synthesized molecularly imprinted polymer indicated higher selectivity towards imatinib mesylate than other compounds. From isotherm study, the equilibrium adsorption data of imatinib mesylate by imprinted polymer were analyzed by Langmuir, Freundlich, and Temkin isotherm models. The developed method was used for determination of imatinib mesylate in human fluid samples by high performance liquid chromatography with excellent results.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31691505</pmid><doi>10.1002/jssc.201900535</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5041-8059</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Azobisisobutyronitrile Fourier transforms High performance liquid chromatography human biological fluids imatinib mesylate Imprinted polymers Infrared analysis Inhibitor drugs Isotherms Methylene bisacrylamide molecularly imprinted polymer Monomers Polymers Polymethyl methacrylate selective extraction Selectivity Thermogravimetric analysis thermosensitive polymer |
| title | Thermosensitive molecularly imprinted poly(1‐vinyl‐2‐pyrrolidone/methyl methacrylate/N‐vinylcaprolactam) for selective extraction of imatinib mesylate in human biological fluid |
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