M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma

Tumor‐associated macrophages (TAMs) have been considered as a major component of the tumor microenvironment. However, the crosstalk between M2‐polarized tumor‐associated macrophages (M2‐TAMs) and intrahepatic cholangiocarcinoma (ICC) remains undetermined. In the present study, we aimed to clarify th...

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Veröffentlicht in:	Journal of cellular biochemistry 2020-04, Vol.121 (4), p.2828-2838
Hauptverfasser:	Sun, Dalong, Luo, Tiancheng, Dong, Pingping, Zhang, Ningping, Chen, Jing, Zhang, Shuncai, Dong, Ling, Janssen, Harry L. A., Zhang, Si
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein AKT1 protein AKT2 protein AKT3 CCL3 protein Chemokines Cholangiocarcinoma Crosstalk Cytokines epithelial‐mesenchymal transition Interleukins intrahepatic cholangiocarcinoma Kinases Macrophages Mesenchyme Metastases Phosphorylation Signal transduction Signaling tumor microenvironment Tumor necrosis factor Tumor necrosis factor-TNF tumor‐associated macrophages
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