Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX

Elevated intraocular pressure (IOP) is the major cause of glaucoma, which is the second leading cause of blindness. However, current glaucoma treatments cannot completely regulate IOP and progression of glaucoma. Our group recently found that autotaxin (ATX) activity in human aqueous humor (AH) was...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2019/11/01, Vol.42(11), pp.1926-1935
Hauptverfasser:	Nagano, Norimichi, Honjo, Megumi, Kawaguchi, Mitsuyasu, Nishimasu, Hiroshi, Nureki, Osamu, Kano, Kuniyuki, Aoki, Junken, Komatsu, Toru, Okabe, Takayoshi, Kojima, Hirotatsu, Nagano, Tetsuo, Aihara, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous Humor Aqueous humour autotaxin Blindness Cell Line Drug Evaluation, Preclinical Endothelial Cells - drug effects Glaucoma Glaucoma - metabolism Glaucoma - physiopathology High-throughput screening Humans Intraocular pressure Intraocular Pressure - drug effects Macaca fascicularis Mice Mice, Inbred C57BL Models, Animal Molecular Structure ocular hypertension Ocular Hypertension - chemically induced Ocular Hypertension - drug therapy Optimization Phosphodiesterase Inhibitors - chemistry Phosphodiesterase Inhibitors - therapeutic use Phosphoric Diester Hydrolases - drug effects Pressure Trabecular Meshwork - drug effects
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