Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice

•Immune regulatory cells significantly increase in oral cancer, with advancing age.•PD-1 and CTLA-4 expression is elevated in T cells of aged oral cancer-bearing mice.•Proliferation of T cells from aged oral cancer-bearing mice is decreased.•Immunotherapies targeting PD-1, CTLA-4, and PD-L1 are more...

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Veröffentlicht in:	Oral oncology 2019-12, Vol.99, p.104462-104462, Article 104462
Hauptverfasser:	Sekido, Katsuhisa, Tomihara, Kei, Tachinami, Hidetake, Heshiki, Wataru, Sakurai, Kotaro, Moniruzzaman, Rohan, Imaue, Shuichi, Fujiwara, Kumiko, Noguchi, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Immune check-point molecules Immunosenescence Immunotherapy Myeloid derived suppressor cells Oral cancer Regulatory T cells
Online-Zugang:	Volltext
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