Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells

Pin1 is one member of a group consisting of three prolyl isomerases. Pin1 interacts with the motif containing phospho-Ser/Thr-Pro of substrates and enhances cis-trans isomerization of peptide bonds, thereby controlling the functions of these substrates. Importantly, the Pin1 expression level is high...

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Veröffentlicht in:	Cancer letters 2020-02, Vol.470, p.106-114
Hauptverfasser:	Nakatsu, Yusuke, Yamamotoya, Takeshi, Ueda, Koji, Ono, Hiraku, Inoue, Masa-Ki, Matsunaga, Yasuka, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Matsubara, Akio, Asano, Tomoichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl CoA carboxylase AMP AMP-Activated kinase (AMPK) AMP-activated protein kinase Angiogenesis Cancer Cell growth Enzymes Fatty acids Genes Glucose Glucose metabolism HIF1 Hypoxia Isomerization Kinases Lipid metabolism Metabolism Peptidylprolyl isomerase Phosphorylation Pin1 Pin1 protein Protein expression Proteins Pyruvate kinase M2 Pyruvic acid Substrates Tumors Warburg effect
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