Molecularly Imprinted Polymers for Cell Recognition
Since their conception 50 years ago, molecularly imprinted polymers (MIPs) have seen extensive development both in terms of synthetic routes and applications. Cells are perhaps the most challenging target for molecular imprinting. Although early work was based almost entirely around microprinting me...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2020-04, Vol.38 (4), p.368-387 |
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| creator | Piletsky, Stanislav Canfarotta, Francesco Poma, Alessandro Bossi, Alessandra Maria Piletsky, Sergey |
| description | Since their conception 50 years ago, molecularly imprinted polymers (MIPs) have seen extensive development both in terms of synthetic routes and applications. Cells are perhaps the most challenging target for molecular imprinting. Although early work was based almost entirely around microprinting methods, recent developments have shifted towards epitope imprinting to generate MIP nanoparticles (NPs). Simultaneously, the development of techniques such as solid phase MIP synthesis has solved many historic issues of MIP production. This review briefly describes various approaches used in cell imprinting with a focus on applications of the created materials in imaging, drug delivery, diagnostics, and tissue engineering.
Molecular imprinting has been developed for both whole cells and cell epitopes.Molecularly imprinted polymer (MIP) materials have been produced for cell recognition, sorting, and separation.MIP materials are suitable recognition elements for sensor development.MIP materials have been used as scaffolds for tissue engineering.When MIPs are produced in nanoscale formats (nanoMIPs), they are suitable for tissue and cell imaging.NanoMIPs have been developed for drug loading and delivery to specific tissue or cell types. |
| doi_str_mv | 10.1016/j.tibtech.2019.10.002 |
| format | Article |
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Molecular imprinting has been developed for both whole cells and cell epitopes.Molecularly imprinted polymer (MIP) materials have been produced for cell recognition, sorting, and separation.MIP materials are suitable recognition elements for sensor development.MIP materials have been used as scaffolds for tissue engineering.When MIPs are produced in nanoscale formats (nanoMIPs), they are suitable for tissue and cell imaging.NanoMIPs have been developed for drug loading and delivery to specific tissue or cell types.</description><identifier>ISSN: 0167-7799</identifier><identifier>EISSN: 1879-3096</identifier><identifier>DOI: 10.1016/j.tibtech.2019.10.002</identifier><identifier>PMID: 31677857</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bacteria ; Binding sites ; Cell adhesion & migration ; Cell recognition ; Cell Tracking ; Diagnostic Imaging ; Drug delivery ; Drug Delivery Systems ; E coli ; Epitopes ; Epitopes - chemistry ; Humans ; Imprinted polymers ; Microprinting ; Molecular Imaging ; Molecular imprinting ; Molecular Imprinting - methods ; molecularly imprinted polymers (MIPs) ; Molecularly Imprinted Polymers - chemical synthesis ; Nanoparticles ; Nanoparticles - chemistry ; Peptides ; Polymerization ; Polymers ; Proteins ; sensors ; Solid phases ; stem cells ; targeted delivery ; Tissue Engineering</subject><ispartof>Trends in biotechnology (Regular ed.), 2020-04, Vol.38 (4), p.368-387</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>2019. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-ec5b1e331a56beedb3610ff79b8b5b6717dfa2084b74fdf88a1c40188e12314d3</citedby><cites>FETCH-LOGICAL-c440t-ec5b1e331a56beedb3610ff79b8b5b6717dfa2084b74fdf88a1c40188e12314d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2417038923?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31677857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piletsky, Stanislav</creatorcontrib><creatorcontrib>Canfarotta, Francesco</creatorcontrib><creatorcontrib>Poma, Alessandro</creatorcontrib><creatorcontrib>Bossi, Alessandra Maria</creatorcontrib><creatorcontrib>Piletsky, Sergey</creatorcontrib><title>Molecularly Imprinted Polymers for Cell Recognition</title><title>Trends in biotechnology (Regular ed.)</title><addtitle>Trends Biotechnol</addtitle><description>Since their conception 50 years ago, molecularly imprinted polymers (MIPs) have seen extensive development both in terms of synthetic routes and applications. Cells are perhaps the most challenging target for molecular imprinting. Although early work was based almost entirely around microprinting methods, recent developments have shifted towards epitope imprinting to generate MIP nanoparticles (NPs). Simultaneously, the development of techniques such as solid phase MIP synthesis has solved many historic issues of MIP production. This review briefly describes various approaches used in cell imprinting with a focus on applications of the created materials in imaging, drug delivery, diagnostics, and tissue engineering.
Molecular imprinting has been developed for both whole cells and cell epitopes.Molecularly imprinted polymer (MIP) materials have been produced for cell recognition, sorting, and separation.MIP materials are suitable recognition elements for sensor development.MIP materials have been used as scaffolds for tissue engineering.When MIPs are produced in nanoscale formats (nanoMIPs), they are suitable for tissue and cell imaging.NanoMIPs have been developed for drug loading and delivery to specific tissue or cell types.</description><subject>Bacteria</subject><subject>Binding sites</subject><subject>Cell adhesion & migration</subject><subject>Cell recognition</subject><subject>Cell Tracking</subject><subject>Diagnostic Imaging</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>E coli</subject><subject>Epitopes</subject><subject>Epitopes - chemistry</subject><subject>Humans</subject><subject>Imprinted polymers</subject><subject>Microprinting</subject><subject>Molecular Imaging</subject><subject>Molecular imprinting</subject><subject>Molecular Imprinting - methods</subject><subject>molecularly imprinted polymers (MIPs)</subject><subject>Molecularly Imprinted Polymers - chemical synthesis</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Peptides</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Proteins</subject><subject>sensors</subject><subject>Solid phases</subject><subject>stem cells</subject><subject>targeted delivery</subject><subject>Tissue 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in terms of synthetic routes and applications. Cells are perhaps the most challenging target for molecular imprinting. Although early work was based almost entirely around microprinting methods, recent developments have shifted towards epitope imprinting to generate MIP nanoparticles (NPs). Simultaneously, the development of techniques such as solid phase MIP synthesis has solved many historic issues of MIP production. This review briefly describes various approaches used in cell imprinting with a focus on applications of the created materials in imaging, drug delivery, diagnostics, and tissue engineering.
Molecular imprinting has been developed for both whole cells and cell epitopes.Molecularly imprinted polymer (MIP) materials have been produced for cell recognition, sorting, and separation.MIP materials are suitable recognition elements for sensor development.MIP materials have been used as scaffolds for tissue engineering.When MIPs are produced in nanoscale formats (nanoMIPs), they are suitable for tissue and cell imaging.NanoMIPs have been developed for drug loading and delivery to specific tissue or cell types.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31677857</pmid><doi>10.1016/j.tibtech.2019.10.002</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bacteria Binding sites Cell adhesion & migration Cell recognition Cell Tracking Diagnostic Imaging Drug delivery Drug Delivery Systems E coli Epitopes Epitopes - chemistry Humans Imprinted polymers Microprinting Molecular Imaging Molecular imprinting Molecular Imprinting - methods molecularly imprinted polymers (MIPs) Molecularly Imprinted Polymers - chemical synthesis Nanoparticles Nanoparticles - chemistry Peptides Polymerization Polymers Proteins sensors Solid phases stem cells targeted delivery Tissue Engineering |
| title | Molecularly Imprinted Polymers for Cell Recognition |
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