Oral treatment with enrofloxacin creates anti-inflammatory environment that supports induction of tolerogenic dendritic cells

•Enrofloxacin treatment-induced dysbiosis altered the immune response.•Antibiotic treatment modulated cytokine production in the gut and peripheral tissues.•Enrofloxacin treatment promoted an anti-inflammatory environment.•Enrofloxacin-induced dysbiosis increased the frequency of tolerogenic dendrit...

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Veröffentlicht in:	International immunopharmacology 2019-12, Vol.77, p.105966-105966, Article 105966
Hauptverfasser:	Strzępa, Anna, Marcińska, Katarzyna, Majewska-Szczepanik, Monika, Szczepanik, Marian
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents - pharmacology Antibiotic Antibiotics CD11b antigen Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Digestive system Dysbacteriosis Dysbiosis Enrofloxacin Enrofloxacin - pharmacology Flora Gastrointestinal Microbiome - drug effects Gastrointestinal tract Genotype & phenotype Immune environment Immune response Immune system Immune Tolerance - drug effects Inflammation Interferon-gamma - metabolism Interleukin 10 Interleukin-10 - metabolism Interleukin-17 - metabolism Intestinal microflora Intestine Latency Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Microbiomes Perturbation Peyer's patches Peyer's Patches - metabolism Phenotypes Spleen Spleen - drug effects Spleen - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Tolerogenic dendritic cells Transforming Growth Factor beta - metabolism γ-Interferon
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