Society of pediatric liver transplantation: Current registry status 2011‐2018
Background SPLIT was founded in 1995 in order to collect comprehensive prospective data on pediatric liver transplantation, including waiting list data, transplant, and early and late outcomes. Since 2011, data collection of the current registry has been refined to focus on prospective data and outc...
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| Veröffentlicht in: | Pediatric transplantation 2020-02, Vol.24 (1), p.e13605-n/a |
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| creator | Elisofon, Scott A. Magee, John C. Horslen, Simon P. Fioravanti, Vicki Economides, Julie Erinjeri, Jinson Anand, Ravinder Mazariegos, George V. Mannino, D. Mohammad, S. Alonso, E. Superina, R. Riordan, M. Lokar, J. Ito, J. Elisofon, S. Jain, A. Gupta, N. Whitlow, C. Naik, K. Espinosa, H. Miethke, A. Hawkins, A. Hardy, J. Engels, E. Schreibeis, A. Kogan‐Liberman, D. Sundaram, S. Feldman, A. Kohli, R. Lopez, J. Bilhartz, J. Hollenbeck, J. Shaw, B. Forest, S. Rand, E. Linguiti, I. Wann, L. Seidman, C. Mazariegos, G. Kepler, A. Vitola, B. Telega, G. Lerret, S. Moghe, J. Cutright, L. Andrews, W. Fioravanti, V. Faseler, M. Hufferd, M. Moats, L. Hobby, A. Rao, G. Boulware, M. Ibrahim, S. Weckwerth, J. Lovejoy, C. Kasi, N. Nadig, S. Law, M. Arnon, R. Chu, J. Bucuvalas, J. Secheli, B. Almy, C. Haydel, B. Lobritto, S. Emand, J. Gamino, D. Gomez, A. Himes, R. Seal, J. Truxillo, A. Davidson, H. Book, L. Jennings, C. Horslen, S. Economides, J. Timmons, K. Ng, V. McDiarmid, S. Perito, E. Gallagher, L. Nogueira, J. Robert, C. Azzam, R. Boone, P. Garbarino, N. Lalonde, M. Kerkar, N. Dokus, K. Helbig, K. Grizzanti, M. Alexopoulos, S. Schillo, R. Bailey, A. Dulek, D. Ekong, U. Valentino, P. Hettiarachchi, D. |
| description | Background
SPLIT was founded in 1995 in order to collect comprehensive prospective data on pediatric liver transplantation, including waiting list data, transplant, and early and late outcomes. Since 2011, data collection of the current registry has been refined to focus on prospective data and outcomes only after transplant to serve as a foundation for the future development of targeted clinical studies.
Objective
To report the outcomes of the SPLIT registry from 2011 to 2018.
Methods
This is a multicenter, cross‐sectional analysis characterizing patients transplanted and enrolled in the SPLIT registry between 2011 and 2018. All patients, |
| doi_str_mv | 10.1111/petr.13605 |
| format | Article |
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SPLIT was founded in 1995 in order to collect comprehensive prospective data on pediatric liver transplantation, including waiting list data, transplant, and early and late outcomes. Since 2011, data collection of the current registry has been refined to focus on prospective data and outcomes only after transplant to serve as a foundation for the future development of targeted clinical studies.
Objective
To report the outcomes of the SPLIT registry from 2011 to 2018.
Methods
This is a multicenter, cross‐sectional analysis characterizing patients transplanted and enrolled in the SPLIT registry between 2011 and 2018. All patients, <18 years of age, received a first liver‐only, a combined liver‐kidney, or a combined liver‐pancreas transplant during this study period.
Results
A total of 1911 recipients from 39 participating centers in North America were registered. Indications included biliary atresia (38.5%), metabolic disease (19.1%), tumors (11.7%), and fulminant liver failure (11.5%). Greater than 50% of recipients were transplanted as either Status 1A/1B or with a MELD/PELD exception score. Incompatible transplants were performed in 4.1%. Kaplan‐Meier estimates of 1‐year patient and graft survival were 97.3% and 96.6%. First 30 days of surgical complications included reoperation (31.7%), hepatic artery thrombosis (6.3%), and portal vein thrombosis (3.2%). In the first 90 days, biliary tract complications were reported in 13.6%. Acute cellular rejection during first year was 34.7%. At 1 and 2 years of follow‐up, 39.2% and 50.6% had normal liver tests on monotherapy (tacrolimus or sirolimus). Further surgical, survival, allograft function, and complications are detailed.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.13605</identifier><identifier>PMID: 31680409</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Allografts ; Biliary atresia ; Biliary tract ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Graft rejection ; Hepatic artery ; Humans ; Infant ; Infant, Newborn ; Liver ; Liver diseases ; Liver Diseases - mortality ; Liver Diseases - surgery ; Liver transplantation ; Liver Transplantation - mortality ; Liver transplants ; Male ; Metabolic disorders ; North America ; outcomes ; Pancreas transplantation ; Patients ; Pediatrics ; Portal vein ; Postoperative Complications - epidemiology ; Rapamycin ; Registries ; Societies, Medical ; Survival Analysis ; Tacrolimus ; Thrombosis ; Transplants & implants ; Treatment Outcome ; Tumors</subject><ispartof>Pediatric transplantation, 2020-02, Vol.24 (1), p.e13605-n/a</ispartof><rights>2019 Wiley Periodicals, Inc</rights><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3935-72aaadb2bcda075171568979d69d3e1734471e3fec4ce14979209659e00977f83</citedby><cites>FETCH-LOGICAL-c3935-72aaadb2bcda075171568979d69d3e1734471e3fec4ce14979209659e00977f83</cites><orcidid>0000-0002-2624-8632 ; 0000-0003-2992-287X ; 0000-0001-5949-7363 ; 0000-0002-9998-5692</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.13605$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.13605$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31680409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elisofon, Scott A.</creatorcontrib><creatorcontrib>Magee, John C.</creatorcontrib><creatorcontrib>Horslen, Simon P.</creatorcontrib><creatorcontrib>Fioravanti, Vicki</creatorcontrib><creatorcontrib>Economides, Julie</creatorcontrib><creatorcontrib>Erinjeri, Jinson</creatorcontrib><creatorcontrib>Anand, Ravinder</creatorcontrib><creatorcontrib>Mazariegos, George V.</creatorcontrib><creatorcontrib>Mannino, D.</creatorcontrib><creatorcontrib>Mohammad, S.</creatorcontrib><creatorcontrib>Alonso, E.</creatorcontrib><creatorcontrib>Superina, R.</creatorcontrib><creatorcontrib>Riordan, M.</creatorcontrib><creatorcontrib>Lokar, J.</creatorcontrib><creatorcontrib>Ito, J.</creatorcontrib><creatorcontrib>Elisofon, S.</creatorcontrib><creatorcontrib>Jain, A.</creatorcontrib><creatorcontrib>Gupta, N.</creatorcontrib><creatorcontrib>Whitlow, C.</creatorcontrib><creatorcontrib>Naik, K.</creatorcontrib><creatorcontrib>Espinosa, H.</creatorcontrib><creatorcontrib>Miethke, A.</creatorcontrib><creatorcontrib>Hawkins, A.</creatorcontrib><creatorcontrib>Hardy, J.</creatorcontrib><creatorcontrib>Engels, E.</creatorcontrib><creatorcontrib>Schreibeis, A.</creatorcontrib><creatorcontrib>Kogan‐Liberman, D.</creatorcontrib><creatorcontrib>Sundaram, S.</creatorcontrib><creatorcontrib>Feldman, A.</creatorcontrib><creatorcontrib>Kohli, R.</creatorcontrib><creatorcontrib>Lopez, J.</creatorcontrib><creatorcontrib>Bilhartz, J.</creatorcontrib><creatorcontrib>Hollenbeck, J.</creatorcontrib><creatorcontrib>Shaw, B.</creatorcontrib><creatorcontrib>Forest, S.</creatorcontrib><creatorcontrib>Rand, E.</creatorcontrib><creatorcontrib>Linguiti, I.</creatorcontrib><creatorcontrib>Wann, L.</creatorcontrib><creatorcontrib>Seidman, C.</creatorcontrib><creatorcontrib>Mazariegos, G.</creatorcontrib><creatorcontrib>Kepler, A.</creatorcontrib><creatorcontrib>Vitola, B.</creatorcontrib><creatorcontrib>Telega, G.</creatorcontrib><creatorcontrib>Lerret, S.</creatorcontrib><creatorcontrib>Moghe, J.</creatorcontrib><creatorcontrib>Cutright, L.</creatorcontrib><creatorcontrib>Andrews, W.</creatorcontrib><creatorcontrib>Fioravanti, V.</creatorcontrib><creatorcontrib>Faseler, M.</creatorcontrib><creatorcontrib>Hufferd, M.</creatorcontrib><creatorcontrib>Moats, L.</creatorcontrib><creatorcontrib>Hobby, A.</creatorcontrib><creatorcontrib>Rao, G.</creatorcontrib><creatorcontrib>Boulware, M.</creatorcontrib><creatorcontrib>Ibrahim, S.</creatorcontrib><creatorcontrib>Weckwerth, J.</creatorcontrib><creatorcontrib>Lovejoy, C.</creatorcontrib><creatorcontrib>Kasi, N.</creatorcontrib><creatorcontrib>Nadig, S.</creatorcontrib><creatorcontrib>Law, M.</creatorcontrib><creatorcontrib>Arnon, R.</creatorcontrib><creatorcontrib>Chu, J.</creatorcontrib><creatorcontrib>Bucuvalas, J.</creatorcontrib><creatorcontrib>Secheli, B.</creatorcontrib><creatorcontrib>Almy, C.</creatorcontrib><creatorcontrib>Haydel, B.</creatorcontrib><creatorcontrib>Lobritto, S.</creatorcontrib><creatorcontrib>Emand, J.</creatorcontrib><creatorcontrib>Gamino, D.</creatorcontrib><creatorcontrib>Gomez, A.</creatorcontrib><creatorcontrib>Himes, R.</creatorcontrib><creatorcontrib>Seal, J.</creatorcontrib><creatorcontrib>Truxillo, A.</creatorcontrib><creatorcontrib>Davidson, H.</creatorcontrib><creatorcontrib>Book, L.</creatorcontrib><creatorcontrib>Jennings, C.</creatorcontrib><creatorcontrib>Horslen, S.</creatorcontrib><creatorcontrib>Economides, J.</creatorcontrib><creatorcontrib>Timmons, K.</creatorcontrib><creatorcontrib>Ng, V.</creatorcontrib><creatorcontrib>McDiarmid, S.</creatorcontrib><creatorcontrib>Perito, E.</creatorcontrib><creatorcontrib>Gallagher, L.</creatorcontrib><creatorcontrib>Nogueira, J.</creatorcontrib><creatorcontrib>Robert, C.</creatorcontrib><creatorcontrib>Azzam, R.</creatorcontrib><creatorcontrib>Boone, P.</creatorcontrib><creatorcontrib>Garbarino, N.</creatorcontrib><creatorcontrib>Lalonde, M.</creatorcontrib><creatorcontrib>Kerkar, N.</creatorcontrib><creatorcontrib>Dokus, K.</creatorcontrib><creatorcontrib>Helbig, K.</creatorcontrib><creatorcontrib>Grizzanti, M.</creatorcontrib><creatorcontrib>Alexopoulos, S.</creatorcontrib><creatorcontrib>Schillo, R.</creatorcontrib><creatorcontrib>Bailey, A.</creatorcontrib><creatorcontrib>Dulek, D.</creatorcontrib><creatorcontrib>Ekong, U.</creatorcontrib><creatorcontrib>Valentino, P.</creatorcontrib><creatorcontrib>Hettiarachchi, D.</creatorcontrib><creatorcontrib>Society of Pediatric Liver Transplantation Research Group</creatorcontrib><creatorcontrib>the Society of Pediatric Liver Transplantation Research Group</creatorcontrib><title>Society of pediatric liver transplantation: Current registry status 2011‐2018</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Background
SPLIT was founded in 1995 in order to collect comprehensive prospective data on pediatric liver transplantation, including waiting list data, transplant, and early and late outcomes. Since 2011, data collection of the current registry has been refined to focus on prospective data and outcomes only after transplant to serve as a foundation for the future development of targeted clinical studies.
Objective
To report the outcomes of the SPLIT registry from 2011 to 2018.
Methods
This is a multicenter, cross‐sectional analysis characterizing patients transplanted and enrolled in the SPLIT registry between 2011 and 2018. All patients, <18 years of age, received a first liver‐only, a combined liver‐kidney, or a combined liver‐pancreas transplant during this study period.
Results
A total of 1911 recipients from 39 participating centers in North America were registered. Indications included biliary atresia (38.5%), metabolic disease (19.1%), tumors (11.7%), and fulminant liver failure (11.5%). Greater than 50% of recipients were transplanted as either Status 1A/1B or with a MELD/PELD exception score. Incompatible transplants were performed in 4.1%. Kaplan‐Meier estimates of 1‐year patient and graft survival were 97.3% and 96.6%. First 30 days of surgical complications included reoperation (31.7%), hepatic artery thrombosis (6.3%), and portal vein thrombosis (3.2%). In the first 90 days, biliary tract complications were reported in 13.6%. Acute cellular rejection during first year was 34.7%. At 1 and 2 years of follow‐up, 39.2% and 50.6% had normal liver tests on monotherapy (tacrolimus or sirolimus). Further surgical, survival, allograft function, and complications are detailed.</description><subject>Adolescent</subject><subject>Allografts</subject><subject>Biliary atresia</subject><subject>Biliary tract</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Graft rejection</subject><subject>Hepatic artery</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver Diseases - mortality</subject><subject>Liver Diseases - surgery</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - mortality</subject><subject>Liver transplants</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>North America</subject><subject>outcomes</subject><subject>Pancreas transplantation</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Portal vein</subject><subject>Postoperative Complications - epidemiology</subject><subject>Rapamycin</subject><subject>Registries</subject><subject>Societies, Medical</subject><subject>Survival Analysis</subject><subject>Tacrolimus</subject><subject>Thrombosis</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtKxDAUBuAgijOObnwAKbgRoZrTpE3jTobxAgMjOq5Lpj2VDJ22JqkyOx_BZ_RJzFx04cJsTuB8_Bx-Qo6BXoB_ly06cwEsofEO6QOTMmSUJ7vrvwgZ8KhHDqydUwoJT_k-6TFIUsqp7JPJU5NrdMugKYMWC62c0XlQ6Tc0gTOqtm2laqecbuqrYNgZg7ULDL5o68wysH7T2SCiAF8fn36kh2SvVJXFo-0ckOeb0XR4F44nt_fD63GYM8niUERKqWIWzfJCURGDgDhJpZBFIguGIBjnApCVmPMcgftNRGUSS6RUClGmbEDONrmtaV47tC5baJtj5a_FprNZxABkBJyCp6d_6LzpTO2v84pzGgshuFfnG5WbxlqDZdYavVBmmQHNVjVnq5qzdc0en2wju9kCi1_606sHsAHvusLlP1HZw2j6uAn9Bv4ShlE</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Elisofon, Scott A.</creator><creator>Magee, John C.</creator><creator>Horslen, Simon P.</creator><creator>Fioravanti, Vicki</creator><creator>Economides, Julie</creator><creator>Erinjeri, Jinson</creator><creator>Anand, 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Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2624-8632</orcidid><orcidid>https://orcid.org/0000-0003-2992-287X</orcidid><orcidid>https://orcid.org/0000-0001-5949-7363</orcidid><orcidid>https://orcid.org/0000-0002-9998-5692</orcidid></search><sort><creationdate>202002</creationdate><title>Society of pediatric liver transplantation: Current registry status 2011‐2018</title><author>Elisofon, Scott A. ; Magee, John C. ; Horslen, Simon P. ; Fioravanti, Vicki ; Economides, Julie ; Erinjeri, Jinson ; Anand, Ravinder ; Mazariegos, George V. ; Mannino, D. ; Mohammad, S. ; Alonso, E. ; Superina, R. ; Riordan, M. ; Lokar, J. ; Ito, J. ; Elisofon, S. ; Jain, A. ; Gupta, N. ; Whitlow, C. ; Naik, K. ; Espinosa, H. ; Miethke, A. ; Hawkins, A. ; Hardy, J. ; Engels, E. ; Schreibeis, A. ; Kogan‐Liberman, D. ; Sundaram, S. ; Feldman, A. ; Kohli, R. ; Lopez, J. ; Bilhartz, J. ; Hollenbeck, J. ; Shaw, B. ; Forest, S. ; Rand, E. ; Linguiti, I. ; Wann, L. ; Seidman, C. ; Mazariegos, G. ; Kepler, A. ; Vitola, B. ; Telega, G. ; Lerret, S. ; Moghe, J. ; Cutright, L. ; Andrews, W. ; Fioravanti, V. ; Faseler, M. ; Hufferd, M. ; Moats, L. ; Hobby, A. ; Rao, G. ; Boulware, M. ; Ibrahim, S. ; Weckwerth, J. ; Lovejoy, C. ; Kasi, N. ; Nadig, S. ; Law, M. ; Arnon, R. ; Chu, J. ; Bucuvalas, J. ; Secheli, B. ; Almy, C. ; Haydel, B. ; Lobritto, S. ; Emand, J. ; Gamino, D. ; Gomez, A. ; Himes, R. ; Seal, J. ; Truxillo, A. ; Davidson, H. ; Book, L. ; Jennings, C. ; Horslen, S. ; Economides, J. ; Timmons, K. ; Ng, V. ; McDiarmid, S. ; Perito, E. ; Gallagher, L. ; Nogueira, J. ; Robert, C. ; Azzam, R. ; Boone, P. ; Garbarino, N. ; Lalonde, M. ; Kerkar, N. ; Dokus, K. ; Helbig, K. ; Grizzanti, M. ; Alexopoulos, S. ; Schillo, R. ; Bailey, A. ; Dulek, D. ; Ekong, U. ; Valentino, P. ; Hettiarachchi, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3935-72aaadb2bcda075171568979d69d3e1734471e3fec4ce14979209659e00977f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Allografts</topic><topic>Biliary atresia</topic><topic>Biliary tract</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Graft rejection</topic><topic>Hepatic artery</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Liver Diseases - mortality</topic><topic>Liver Diseases - surgery</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - mortality</topic><topic>Liver transplants</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>North America</topic><topic>outcomes</topic><topic>Pancreas transplantation</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Portal vein</topic><topic>Postoperative Complications - epidemiology</topic><topic>Rapamycin</topic><topic>Registries</topic><topic>Societies, Medical</topic><topic>Survival Analysis</topic><topic>Tacrolimus</topic><topic>Thrombosis</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elisofon, Scott A.</creatorcontrib><creatorcontrib>Magee, John C.</creatorcontrib><creatorcontrib>Horslen, Simon P.</creatorcontrib><creatorcontrib>Fioravanti, Vicki</creatorcontrib><creatorcontrib>Economides, Julie</creatorcontrib><creatorcontrib>Erinjeri, Jinson</creatorcontrib><creatorcontrib>Anand, Ravinder</creatorcontrib><creatorcontrib>Mazariegos, George V.</creatorcontrib><creatorcontrib>Mannino, D.</creatorcontrib><creatorcontrib>Mohammad, S.</creatorcontrib><creatorcontrib>Alonso, E.</creatorcontrib><creatorcontrib>Superina, R.</creatorcontrib><creatorcontrib>Riordan, M.</creatorcontrib><creatorcontrib>Lokar, J.</creatorcontrib><creatorcontrib>Ito, J.</creatorcontrib><creatorcontrib>Elisofon, S.</creatorcontrib><creatorcontrib>Jain, A.</creatorcontrib><creatorcontrib>Gupta, N.</creatorcontrib><creatorcontrib>Whitlow, C.</creatorcontrib><creatorcontrib>Naik, K.</creatorcontrib><creatorcontrib>Espinosa, H.</creatorcontrib><creatorcontrib>Miethke, A.</creatorcontrib><creatorcontrib>Hawkins, A.</creatorcontrib><creatorcontrib>Hardy, J.</creatorcontrib><creatorcontrib>Engels, E.</creatorcontrib><creatorcontrib>Schreibeis, A.</creatorcontrib><creatorcontrib>Kogan‐Liberman, D.</creatorcontrib><creatorcontrib>Sundaram, S.</creatorcontrib><creatorcontrib>Feldman, A.</creatorcontrib><creatorcontrib>Kohli, R.</creatorcontrib><creatorcontrib>Lopez, J.</creatorcontrib><creatorcontrib>Bilhartz, J.</creatorcontrib><creatorcontrib>Hollenbeck, J.</creatorcontrib><creatorcontrib>Shaw, B.</creatorcontrib><creatorcontrib>Forest, S.</creatorcontrib><creatorcontrib>Rand, E.</creatorcontrib><creatorcontrib>Linguiti, I.</creatorcontrib><creatorcontrib>Wann, L.</creatorcontrib><creatorcontrib>Seidman, C.</creatorcontrib><creatorcontrib>Mazariegos, G.</creatorcontrib><creatorcontrib>Kepler, A.</creatorcontrib><creatorcontrib>Vitola, B.</creatorcontrib><creatorcontrib>Telega, G.</creatorcontrib><creatorcontrib>Lerret, S.</creatorcontrib><creatorcontrib>Moghe, J.</creatorcontrib><creatorcontrib>Cutright, L.</creatorcontrib><creatorcontrib>Andrews, W.</creatorcontrib><creatorcontrib>Fioravanti, V.</creatorcontrib><creatorcontrib>Faseler, M.</creatorcontrib><creatorcontrib>Hufferd, M.</creatorcontrib><creatorcontrib>Moats, L.</creatorcontrib><creatorcontrib>Hobby, A.</creatorcontrib><creatorcontrib>Rao, G.</creatorcontrib><creatorcontrib>Boulware, M.</creatorcontrib><creatorcontrib>Ibrahim, S.</creatorcontrib><creatorcontrib>Weckwerth, J.</creatorcontrib><creatorcontrib>Lovejoy, C.</creatorcontrib><creatorcontrib>Kasi, N.</creatorcontrib><creatorcontrib>Nadig, S.</creatorcontrib><creatorcontrib>Law, M.</creatorcontrib><creatorcontrib>Arnon, R.</creatorcontrib><creatorcontrib>Chu, J.</creatorcontrib><creatorcontrib>Bucuvalas, J.</creatorcontrib><creatorcontrib>Secheli, B.</creatorcontrib><creatorcontrib>Almy, C.</creatorcontrib><creatorcontrib>Haydel, B.</creatorcontrib><creatorcontrib>Lobritto, S.</creatorcontrib><creatorcontrib>Emand, J.</creatorcontrib><creatorcontrib>Gamino, D.</creatorcontrib><creatorcontrib>Gomez, A.</creatorcontrib><creatorcontrib>Himes, R.</creatorcontrib><creatorcontrib>Seal, J.</creatorcontrib><creatorcontrib>Truxillo, A.</creatorcontrib><creatorcontrib>Davidson, H.</creatorcontrib><creatorcontrib>Book, L.</creatorcontrib><creatorcontrib>Jennings, C.</creatorcontrib><creatorcontrib>Horslen, S.</creatorcontrib><creatorcontrib>Economides, J.</creatorcontrib><creatorcontrib>Timmons, K.</creatorcontrib><creatorcontrib>Ng, V.</creatorcontrib><creatorcontrib>McDiarmid, S.</creatorcontrib><creatorcontrib>Perito, E.</creatorcontrib><creatorcontrib>Gallagher, L.</creatorcontrib><creatorcontrib>Nogueira, J.</creatorcontrib><creatorcontrib>Robert, C.</creatorcontrib><creatorcontrib>Azzam, R.</creatorcontrib><creatorcontrib>Boone, P.</creatorcontrib><creatorcontrib>Garbarino, N.</creatorcontrib><creatorcontrib>Lalonde, M.</creatorcontrib><creatorcontrib>Kerkar, N.</creatorcontrib><creatorcontrib>Dokus, K.</creatorcontrib><creatorcontrib>Helbig, K.</creatorcontrib><creatorcontrib>Grizzanti, M.</creatorcontrib><creatorcontrib>Alexopoulos, S.</creatorcontrib><creatorcontrib>Schillo, R.</creatorcontrib><creatorcontrib>Bailey, A.</creatorcontrib><creatorcontrib>Dulek, D.</creatorcontrib><creatorcontrib>Ekong, U.</creatorcontrib><creatorcontrib>Valentino, P.</creatorcontrib><creatorcontrib>Hettiarachchi, D.</creatorcontrib><creatorcontrib>Society of Pediatric Liver Transplantation Research Group</creatorcontrib><creatorcontrib>the Society of Pediatric Liver Transplantation Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elisofon, Scott A.</au><au>Magee, John C.</au><au>Horslen, Simon P.</au><au>Fioravanti, Vicki</au><au>Economides, Julie</au><au>Erinjeri, Jinson</au><au>Anand, Ravinder</au><au>Mazariegos, George V.</au><au>Mannino, D.</au><au>Mohammad, S.</au><au>Alonso, E.</au><au>Superina, R.</au><au>Riordan, M.</au><au>Lokar, J.</au><au>Ito, J.</au><au>Elisofon, S.</au><au>Jain, A.</au><au>Gupta, N.</au><au>Whitlow, C.</au><au>Naik, K.</au><au>Espinosa, H.</au><au>Miethke, A.</au><au>Hawkins, A.</au><au>Hardy, J.</au><au>Engels, E.</au><au>Schreibeis, A.</au><au>Kogan‐Liberman, D.</au><au>Sundaram, S.</au><au>Feldman, A.</au><au>Kohli, R.</au><au>Lopez, J.</au><au>Bilhartz, J.</au><au>Hollenbeck, J.</au><au>Shaw, B.</au><au>Forest, S.</au><au>Rand, E.</au><au>Linguiti, I.</au><au>Wann, L.</au><au>Seidman, C.</au><au>Mazariegos, G.</au><au>Kepler, A.</au><au>Vitola, B.</au><au>Telega, G.</au><au>Lerret, S.</au><au>Moghe, J.</au><au>Cutright, L.</au><au>Andrews, W.</au><au>Fioravanti, V.</au><au>Faseler, M.</au><au>Hufferd, M.</au><au>Moats, L.</au><au>Hobby, A.</au><au>Rao, G.</au><au>Boulware, M.</au><au>Ibrahim, S.</au><au>Weckwerth, J.</au><au>Lovejoy, C.</au><au>Kasi, N.</au><au>Nadig, S.</au><au>Law, M.</au><au>Arnon, R.</au><au>Chu, J.</au><au>Bucuvalas, J.</au><au>Secheli, B.</au><au>Almy, C.</au><au>Haydel, B.</au><au>Lobritto, S.</au><au>Emand, J.</au><au>Gamino, D.</au><au>Gomez, A.</au><au>Himes, R.</au><au>Seal, J.</au><au>Truxillo, A.</au><au>Davidson, H.</au><au>Book, L.</au><au>Jennings, C.</au><au>Horslen, S.</au><au>Economides, J.</au><au>Timmons, K.</au><au>Ng, V.</au><au>McDiarmid, S.</au><au>Perito, E.</au><au>Gallagher, L.</au><au>Nogueira, J.</au><au>Robert, C.</au><au>Azzam, R.</au><au>Boone, P.</au><au>Garbarino, N.</au><au>Lalonde, M.</au><au>Kerkar, N.</au><au>Dokus, K.</au><au>Helbig, K.</au><au>Grizzanti, M.</au><au>Alexopoulos, S.</au><au>Schillo, R.</au><au>Bailey, A.</au><au>Dulek, D.</au><au>Ekong, U.</au><au>Valentino, P.</au><au>Hettiarachchi, D.</au><aucorp>Society of Pediatric Liver Transplantation Research Group</aucorp><aucorp>the Society of Pediatric Liver Transplantation Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Society of pediatric liver transplantation: Current registry status 2011‐2018</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2020-02</date><risdate>2020</risdate><volume>24</volume><issue>1</issue><spage>e13605</spage><epage>n/a</epage><pages>e13605-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Background
SPLIT was founded in 1995 in order to collect comprehensive prospective data on pediatric liver transplantation, including waiting list data, transplant, and early and late outcomes. Since 2011, data collection of the current registry has been refined to focus on prospective data and outcomes only after transplant to serve as a foundation for the future development of targeted clinical studies.
Objective
To report the outcomes of the SPLIT registry from 2011 to 2018.
Methods
This is a multicenter, cross‐sectional analysis characterizing patients transplanted and enrolled in the SPLIT registry between 2011 and 2018. All patients, <18 years of age, received a first liver‐only, a combined liver‐kidney, or a combined liver‐pancreas transplant during this study period.
Results
A total of 1911 recipients from 39 participating centers in North America were registered. Indications included biliary atresia (38.5%), metabolic disease (19.1%), tumors (11.7%), and fulminant liver failure (11.5%). Greater than 50% of recipients were transplanted as either Status 1A/1B or with a MELD/PELD exception score. Incompatible transplants were performed in 4.1%. Kaplan‐Meier estimates of 1‐year patient and graft survival were 97.3% and 96.6%. First 30 days of surgical complications included reoperation (31.7%), hepatic artery thrombosis (6.3%), and portal vein thrombosis (3.2%). In the first 90 days, biliary tract complications were reported in 13.6%. Acute cellular rejection during first year was 34.7%. At 1 and 2 years of follow‐up, 39.2% and 50.6% had normal liver tests on monotherapy (tacrolimus or sirolimus). Further surgical, survival, allograft function, and complications are detailed.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31680409</pmid><doi>10.1111/petr.13605</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2624-8632</orcidid><orcidid>https://orcid.org/0000-0003-2992-287X</orcidid><orcidid>https://orcid.org/0000-0001-5949-7363</orcidid><orcidid>https://orcid.org/0000-0002-9998-5692</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1397-3142 |
| ispartof | Pediatric transplantation, 2020-02, Vol.24 (1), p.e13605-n/a |
| issn | 1397-3142 1399-3046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2311921401 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Allografts Biliary atresia Biliary tract Child Child, Preschool Cross-Sectional Studies Female Graft rejection Hepatic artery Humans Infant Infant, Newborn Liver Liver diseases Liver Diseases - mortality Liver Diseases - surgery Liver transplantation Liver Transplantation - mortality Liver transplants Male Metabolic disorders North America outcomes Pancreas transplantation Patients Pediatrics Portal vein Postoperative Complications - epidemiology Rapamycin Registries Societies, Medical Survival Analysis Tacrolimus Thrombosis Transplants & implants Treatment Outcome Tumors |
| title | Society of pediatric liver transplantation: Current registry status 2011‐2018 |
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