miR‐181b/Oncostatin m axis inhibits prostate cancer bone metastasis via modulating osteoclast differentiation

The activation of osteoblasts is significantly correlated to prostate tumor bone metastasis and bone loss. Oncostatin M (OSM) could promote breast cancer metastasis to bone. However, its role and mechanism in prostate cancer bone metastasis remain unclear. MicroRNAs (miRNAs) could play important rol...

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Veröffentlicht in:	Journal of cellular biochemistry 2020-02, Vol.121 (2), p.1664-1674
Hauptverfasser:	Han, Ziwei, Zhan, Ruisen, Chen, Shijie, Deng, Jia, Shi, Jian, Wang, Weiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical materials Bone cancer Bone loss Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary Bone tumors Breast cancer Cell culture Cell Differentiation Cell migration Cell proliferation Differentiation DNA microarrays Gene expression Gene sequencing Genes Male Metastases Metastasis Mice MicroRNAs - biosynthesis MicroRNAs - genetics migration miRNA miR‐181b‐5p Neoplasm Metastasis Oncostatin M Oncostatin M (OSM) Oncostatin M - biosynthesis Oncostatin M - genetics Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Osteoblasts - pathology Osteoclastogenesis Osteoprotegerin proliferation Prostate cancer prostate cancer bone metastasis Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RAW 264.7 Cells Therapeutic applications Transcription Tumors
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