Targeting PI3K/Akt/mTOR Pathway Identifies Differential Expression and Functional Role of IL8 in Liver Cancer Stem Cell Enrichment

Activation of the PI3K/Akt/mTOR pathway is an important signaling mechanism involved in the development and the progression of liver cancer stem cell (LCSC) population during acquired Sorafenib resistance in advanced hepatocellular carcinoma (HCC). Therefore, identification of novel therapeutic targ...

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Veröffentlicht in:	Molecular cancer therapeutics 2019-11, Vol.18 (11), p.2146-2157
Hauptverfasser:	Kahraman, Deniz Cansen, Kahraman, Tamer, Cetin-Atalay, Rengul
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Humans Interleukin-8 - genetics Interleukin-8 - metabolism Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Sirolimus - pharmacology Sorafenib - pharmacology Sulfonamides - pharmacology TOR Serine-Threonine Kinases - metabolism
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