Vascular adenosine monophosphate‐activated protein kinase: Enhancer, brake or both?

Adenosine monophosphate‐activated protein kinase (AMPK), expressed/present ubiquitously in the body, contributes to metabolic regulation. In the vasculature, activation of AMPK is associated with several beneficial biological effects including enhancement of vasodilatation, reduction of oxidative st...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2020-08, Vol.127 (2), p.81-91
Hauptverfasser:	Chen, Hui, Vanhoutte, Paul Michel, Leung, Susan Wai Sum
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Adenosine kinase Adenosine monophosphate adenosine monophosphate‐activated protein kinase Adipocytes AMP AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Arteries Berberine Biological effects Blood pressure Blood vessels Calcium Calcium signalling Chemical compounds Diabetes mellitus Diabetes Mellitus - enzymology Diabetes Mellitus - physiopathology Endothelial cells endothelial dysfunction endothelial nitric oxide synthase Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - physiopathology endothelium‐dependent hyperpolarization Fenofibrate Genetic modification Glucose tolerance Herbal medicine Humans Hyperpolarization Hypoglycemic Agents - pharmacology Inflammation Kinases Lipids Medicinal herbs Medicinal plants Metabolism Metformin Microvasculature Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - physiopathology Muscles Nitric oxide Nitric Oxide - metabolism Oxidative stress Pharmacology Potassium potassium channels Potassium Channels - metabolism Prostaglandin endoperoxide synthase Protein kinase Proteins Signal Transduction Smooth muscle Vasoconstriction Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilation Vasodilation - drug effects Vasodilation - physiology
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