MiR‐142‐3p functions as a tumor suppressor by targeting RAC1/PAK1 pathway in breast cancer

MicroRNA‐142‐3p (miR‐142‐3p) was previously investigated in various cancers, whereas, it's role in breast cancer (BC) remains far from understood. In this study, we found that miR‐142‐3p was markedly decreased both in cell lines and BC tumor tissues. Elevated miR‐142‐3p expression suppressed gr...

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Veröffentlicht in:	Journal of cellular physiology 2020-05, Vol.235 (5), p.4928-4940
Hauptverfasser:	Xu, Tao, He, Bang‐Shun, Pan, Bei, Pan, Yu‐Qin, Sun, Hui‐Ling, Liu, Xiang‐Xiang, Xu, Xue‐Ni, Chen, Xiao‐Xiang, Zeng, Kai‐Xuan, Xu, Mu, Wang, Shu‐Kui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biotechnology Botulinum toxin Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Movement Cell Proliferation Databases, Genetic Female Gene Expression Regulation, Neoplastic Humans MCF-7 Cells Mesenchyme Metastases Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miRNA miR‐142‐3p Neoplasm Invasiveness Neovascularization, Pathologic p21-Activated Kinases - genetics p21-Activated Kinases - metabolism PAK1 Phosphorylation Proteins RAC1 rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rac1 protein Signal Transduction Substrates Therapeutic applications Toxins Tumor cell lines Tumor suppressor genes Tumors
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