Investigation of the preliminary mechanism of action for the acute anti-inflammatory activity of the methanol extract of Smilax ornata Lem
In folkloric medicine the dried rhizome of the Jamaican sarsaparilla (Smilax ornate Lem.), is given as a decoction to treat chronic rheumatism and rheumatoid arthritis. This particular claim has been scientifically validated; however, the mechanism for its anti-inflammatory activity is still unknown...
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| Veröffentlicht in: | Journal of ethnopharmacology 2020-02, Vol.248, p.112360-112360, Article 112360 |
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| container_title | Journal of ethnopharmacology |
| container_volume | 248 |
| creator | Khan, Ahmad Singh, Paul D. Reese, Paul B. Howden, Jevan Golding, Mario Thomas, Tia T. |
| description | In folkloric medicine the dried rhizome of the Jamaican sarsaparilla (Smilax ornate Lem.), is given as a decoction to treat chronic rheumatism and rheumatoid arthritis. This particular claim has been scientifically validated; however, the mechanism for its anti-inflammatory activity is still unknown and hence, it forms the reason for this investigation.
The objective of this study is to investigate the mechanism of the anti-inflammatory activity of the methanol extract of Smilax ornate Lem.
The methanol extract was prepared using the soxhlet apparatus. The preliminary mechanism of action was investigated using models of oedema induced by histamine, bradykinin and prostaglandin E2.
For the histamine-induced oedema model, the methanol extract (400 mg/kg) reduced the oedema formation, however, it was not significant (P > 0.05). For the bradykinin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P |
| doi_str_mv | 10.1016/j.jep.2019.112360 |
| format | Article |
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The objective of this study is to investigate the mechanism of the anti-inflammatory activity of the methanol extract of Smilax ornate Lem.
The methanol extract was prepared using the soxhlet apparatus. The preliminary mechanism of action was investigated using models of oedema induced by histamine, bradykinin and prostaglandin E2.
For the histamine-induced oedema model, the methanol extract (400 mg/kg) reduced the oedema formation, however, it was not significant (P > 0.05). For the bradykinin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P < 0.05) anti-inflammatory activity when compared with that of the control (saline) group, with an onset on 60 min and a duration of 2 h. For the prostaglandin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P < 0.05) anti-inflammatory activity when compared with that of its control group, with an onset on 120 min and a duration of 1.5 h.
The methanol extract of Smilax ornata Lem. produced significant anti-inflammatory activity in the bradykinin-induced and prostaglandin-induced oedema models. It is possible that the mechanism by which it acts is by reducing the concentration or blocking the action of these mediators.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2019.112360</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Anti-inflammatory activity ; Bradykinin and prostaglandin E2 ; Histamine ; Methanol extract ; Smilax ornata Lem</subject><ispartof>Journal of ethnopharmacology, 2020-02, Vol.248, p.112360-112360, Article 112360</ispartof><rights>2019 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c282t-65842a6f4de264db538474f87e13cbf9f0a0a6d4bbfb01c2ec4a0cae7dbeb9d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2019.112360$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids></links><search><creatorcontrib>Khan, Ahmad</creatorcontrib><creatorcontrib>Singh, Paul D.</creatorcontrib><creatorcontrib>Reese, Paul B.</creatorcontrib><creatorcontrib>Howden, Jevan</creatorcontrib><creatorcontrib>Golding, Mario</creatorcontrib><creatorcontrib>Thomas, Tia T.</creatorcontrib><title>Investigation of the preliminary mechanism of action for the acute anti-inflammatory activity of the methanol extract of Smilax ornata Lem</title><title>Journal of ethnopharmacology</title><description>In folkloric medicine the dried rhizome of the Jamaican sarsaparilla (Smilax ornate Lem.), is given as a decoction to treat chronic rheumatism and rheumatoid arthritis. This particular claim has been scientifically validated; however, the mechanism for its anti-inflammatory activity is still unknown and hence, it forms the reason for this investigation.
The objective of this study is to investigate the mechanism of the anti-inflammatory activity of the methanol extract of Smilax ornate Lem.
The methanol extract was prepared using the soxhlet apparatus. The preliminary mechanism of action was investigated using models of oedema induced by histamine, bradykinin and prostaglandin E2.
For the histamine-induced oedema model, the methanol extract (400 mg/kg) reduced the oedema formation, however, it was not significant (P > 0.05). For the bradykinin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P < 0.05) anti-inflammatory activity when compared with that of the control (saline) group, with an onset on 60 min and a duration of 2 h. For the prostaglandin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P < 0.05) anti-inflammatory activity when compared with that of its control group, with an onset on 120 min and a duration of 1.5 h.
The methanol extract of Smilax ornata Lem. produced significant anti-inflammatory activity in the bradykinin-induced and prostaglandin-induced oedema models. It is possible that the mechanism by which it acts is by reducing the concentration or blocking the action of these mediators.
[Display omitted]</description><subject>Anti-inflammatory activity</subject><subject>Bradykinin and prostaglandin E2</subject><subject>Histamine</subject><subject>Methanol extract</subject><subject>Smilax ornata Lem</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMFOGzEQhi3USg2UB-htj71sansdeyNOCAFFisQBOFuz3jE4Wtup7UTwCn3qeglce_FInu__pfkI-cHoklEmf22XW9wtOWXrJWO8k_SELFiveKtWqvtCFrRTfdsrwb6R05y3lFLFBF2Qv3fhgLm4Zyguhibaprxgs0s4Oe8CpLfGo3mB4LKfl2DeMRvTOwdmX-obimtdsBN4DyXWzIwdXHn77PNYakecGnwtqS7n_wfvJnhtYgpQoNmg_06-Wpgynn_MM_J0c_149bvd3N_eXV1uWsN7Xlq56gUHacWIXIpxWHW9UML2CllnBru2FCjIUQyDHSgzHI0AagDVOOCwHlfdGfl57N2l-Gdfj9feZYPTBAHjPmveMSaFklRWlB1Rk2LOCa3eJeerFc2onr3rra7e9exdH73XzMUxg_WGg8Oks3EYDI4uoSl6jO4_6X-F_I7w</recordid><startdate>20200210</startdate><enddate>20200210</enddate><creator>Khan, Ahmad</creator><creator>Singh, Paul D.</creator><creator>Reese, Paul B.</creator><creator>Howden, Jevan</creator><creator>Golding, Mario</creator><creator>Thomas, Tia T.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200210</creationdate><title>Investigation of the preliminary mechanism of action for the acute anti-inflammatory activity of the methanol extract of Smilax ornata Lem</title><author>Khan, Ahmad ; Singh, Paul D. ; Reese, Paul B. ; Howden, Jevan ; Golding, Mario ; Thomas, Tia T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-65842a6f4de264db538474f87e13cbf9f0a0a6d4bbfb01c2ec4a0cae7dbeb9d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anti-inflammatory activity</topic><topic>Bradykinin and prostaglandin E2</topic><topic>Histamine</topic><topic>Methanol extract</topic><topic>Smilax ornata Lem</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Ahmad</creatorcontrib><creatorcontrib>Singh, Paul D.</creatorcontrib><creatorcontrib>Reese, Paul B.</creatorcontrib><creatorcontrib>Howden, Jevan</creatorcontrib><creatorcontrib>Golding, Mario</creatorcontrib><creatorcontrib>Thomas, Tia T.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Ahmad</au><au>Singh, Paul D.</au><au>Reese, Paul B.</au><au>Howden, Jevan</au><au>Golding, Mario</au><au>Thomas, Tia T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the preliminary mechanism of action for the acute anti-inflammatory activity of the methanol extract of Smilax ornata Lem</atitle><jtitle>Journal of ethnopharmacology</jtitle><date>2020-02-10</date><risdate>2020</risdate><volume>248</volume><spage>112360</spage><epage>112360</epage><pages>112360-112360</pages><artnum>112360</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>In folkloric medicine the dried rhizome of the Jamaican sarsaparilla (Smilax ornate Lem.), is given as a decoction to treat chronic rheumatism and rheumatoid arthritis. This particular claim has been scientifically validated; however, the mechanism for its anti-inflammatory activity is still unknown and hence, it forms the reason for this investigation.
The objective of this study is to investigate the mechanism of the anti-inflammatory activity of the methanol extract of Smilax ornate Lem.
The methanol extract was prepared using the soxhlet apparatus. The preliminary mechanism of action was investigated using models of oedema induced by histamine, bradykinin and prostaglandin E2.
For the histamine-induced oedema model, the methanol extract (400 mg/kg) reduced the oedema formation, however, it was not significant (P > 0.05). For the bradykinin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P < 0.05) anti-inflammatory activity when compared with that of the control (saline) group, with an onset on 60 min and a duration of 2 h. For the prostaglandin-induced oedema model, the methanol extract (400 mg/kg) exhibited significant (P < 0.05) anti-inflammatory activity when compared with that of its control group, with an onset on 120 min and a duration of 1.5 h.
The methanol extract of Smilax ornata Lem. produced significant anti-inflammatory activity in the bradykinin-induced and prostaglandin-induced oedema models. It is possible that the mechanism by which it acts is by reducing the concentration or blocking the action of these mediators.
[Display omitted]</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.jep.2019.112360</doi><tpages>1</tpages></addata></record> |
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| issn | 0378-8741 1872-7573 |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Anti-inflammatory activity Bradykinin and prostaglandin E2 Histamine Methanol extract Smilax ornata Lem |
| title | Investigation of the preliminary mechanism of action for the acute anti-inflammatory activity of the methanol extract of Smilax ornata Lem |
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