HSPA1A conformational mutants reveal a conserved structural unit in Hsp70 proteins

The Hsp70 proteins maintain proteome integrity through the capacity of their nucleotide- and substrate-binding domains (NBD and SBD) to allosterically regulate substrate affinity in a nucleotide-dependent manner. Crystallographic studies showed that Hsp70 allostery relies on formation of contacts be...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects 2020-01, Vol.1864 (1), p.129458-129458, Article 129458
Hauptverfasser:	Vandova, Veronika, Vankova, Pavla, Durech, Michal, Houser, Josef, Kavan, Daniel, Man, Petr, Muller, Petr, Trcka, Filip
Format:	Artikel
Sprache:	eng
Schlagworte:	Allostery Folding Heat-shock protein 70 Molecular chaperones Mutation
Online-Zugang:	Volltext
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