Persistent Dengue Infection in an Immunosuppressed Patient Reveals the Roles of Humoral and Cellular Immune Responses in Virus Clearance

Detailed understanding of the roles of humoral and cellular immune responses in sterilizing dengue virus (DENV) infection in humans is required to inform effective vaccine development. We report an unusual case of persistent DENV infection in a lymphopenic renal transplant recipient who was therapeu...

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Veröffentlicht in:	Cell host & microbe 2019-11, Vol.26 (5), p.601-605.e3
Hauptverfasser:	Ng, Kar-Hui, Zhang, Summer Lixin, Tan, Hwee Cheng, Kwek, Swee Sen, Sessions, October Michael, Chan, Chang-Yien, Liu, Isaac Desheng, Lee, Chun Kiat, Tambyah, Paul Ananth, Ooi, Eng Eong, Yap, Hui-Kim
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology CD8-Positive T-Lymphocytes - immunology Cell Line cellular immune response Cricetinae dengue Dengue - complications Dengue - immunology Dengue Virus - immunology Female Humans humoral immune response Immunity, Cellular - immunology Immunity, Humoral - immunology Immunocompromised Host - immunology immunosuppressed host Kidney Transplantation Lupus Erythematosus, Systemic - complications Lymphocyte Count Lymphopenia - complications Lymphopenia - immunology renal transplant recipient RNA, Viral - blood sterilizing infection vaccine Young Adult
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