Tyrosine modified irinotecan-loaded liposomes capable of simultaneously targeting LAT1 and ATB0,+ for efficient tumor therapy

[Display omitted] As the demand for nutrients in malignant proliferation of tumors increases, the L-type amino acid transporter 1(LAT1) and amino acid transporter B0,+ (ATB0,+) of tumor cells are more highly expressed than normal cells which can be used as new targets for active targeting of cancer....

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Veröffentlicht in:	Journal of controlled release 2019-12, Vol.316, p.22-33
Hauptverfasser:	Wang, Zhenjie, Chi, Dongxu, Wu, Xingchen, Wang, Yingli, Lin, Xinxin, Xu, Zhaochu, Liu, Hongzhuo, Sun, Jin, He, Zhonggui, Wang, Yongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Active drug loading Amino acid transporter ATB0 CPT-11 Dual-targeted liposomes LAT1
Online-Zugang:	Volltext
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