Comparison of plasma, saliva, and hair lamotrigine concentrations
In some clinical situations (pregnancy, aging, drug resistance, toxicity), measurements of lamotrigine plasma levels may be reliable. Limited studies indicate that saliva and hair could be alternative sources for monitoring lamotrigine therapy. The drug content in hair can also be used to assess the...
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| Veröffentlicht in: | Clinical biochemistry 2019-12, Vol.74, p.24-30 |
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| creator | Kuczynska, Julita Karas-Ruszczyk, Katarzyna Zakrzewska, Alicja Dermanowski, Michał Sienkiewicz-Jarosz, Halina Kurkowska-Jastrzebska, Iwona Bienkowski, Przemysław Konopko, Magdalena Dominiak, Monika Mierzejewski, Paweł |
| description | In some clinical situations (pregnancy, aging, drug resistance, toxicity), measurements of lamotrigine plasma levels may be reliable. Limited studies indicate that saliva and hair could be alternative sources for monitoring lamotrigine therapy. The drug content in hair can also be used to assess the history of drug therapy and to ascertain long-term patient compliance. The aims of this study were to 1) determine the correlations among plasma, saliva, and hair lamotrigine concentrations, 2) evaluate saliva as an alternative matrix for monitoring drug levels and 3) evaluate hair as a source of information on adherence to antiepileptic treatment and on the correlation of hair concentrations with clinical outcomes in patients with epilepsy.
Plasma, saliva, and hair lamotrigine concentrations were measured by liquid chromatography–tandem mass spectrometry in positive ionization mode. The study group (n = 85) was recruited among the epileptic patients at the Institute of Psychiatry and Neurology, Warsaw, Poland.
Plasma concentrations were not influenced by sex, age, or the concomitant use of other antiepileptic drugs. Lamotrigine saliva and plasma concentrations were strongly correlated (r = 0.82, p |
| doi_str_mv | 10.1016/j.clinbiochem.2019.09.009 |
| format | Article |
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Plasma, saliva, and hair lamotrigine concentrations were measured by liquid chromatography–tandem mass spectrometry in positive ionization mode. The study group (n = 85) was recruited among the epileptic patients at the Institute of Psychiatry and Neurology, Warsaw, Poland.
Plasma concentrations were not influenced by sex, age, or the concomitant use of other antiepileptic drugs. Lamotrigine saliva and plasma concentrations were strongly correlated (r = 0.82, p < 0.001). Lamotrigine hair concentrations were correlated with the plasma concentrations (r = 0.53, p < 0.001) and daily dose in mg/kg (r = 0.23, p = 0.024). The analysis revealed no significant correlation between lamotrigine hair levels and the number of seizures in the previous 3 months (r = -0.1, p > 0.05).
The lamotrigine saliva concentration is strongly correlated with its plasma level, and saliva can be used as an alternative matrix to plasma for monitoring. Lamotrigine can also be successfully measured in hair, and the drug levels in hair tend to be correlated with the levels in plasma. However, lamotrigine levels in hair may not correspond to clinical outcomes (i.e., seizure episodes).</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2019.09.009</identifier><identifier>PMID: 31672648</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Anticonvulsants - administration & dosage ; Anticonvulsants - analysis ; Anticonvulsants - blood ; Anticonvulsants - therapeutic use ; Chromatography, Liquid ; Drug Monitoring - methods ; Epilepsy ; Epilepsy - blood ; Epilepsy - drug therapy ; Female ; Hair ; Hair - chemistry ; Humans ; Lamotrigine ; Lamotrigine - administration & dosage ; Lamotrigine - analysis ; Lamotrigine - blood ; Lamotrigine - therapeutic use ; Male ; Middle Aged ; Plasma ; Poland ; Saliva ; Saliva - chemistry ; Seizures - blood ; Seizures - drug therapy ; Tandem Mass Spectrometry ; Young Adult</subject><ispartof>Clinical biochemistry, 2019-12, Vol.74, p.24-30</ispartof><rights>2019 The Canadian Society of Clinical Chemists</rights><rights>Copyright © 2019 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-efaca61b533b01c59b18f7f95d3326ad04ad267f8a6335b47af69626e517e3ae3</citedby><cites>FETCH-LOGICAL-c377t-efaca61b533b01c59b18f7f95d3326ad04ad267f8a6335b47af69626e517e3ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2019.09.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31672648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuczynska, Julita</creatorcontrib><creatorcontrib>Karas-Ruszczyk, Katarzyna</creatorcontrib><creatorcontrib>Zakrzewska, Alicja</creatorcontrib><creatorcontrib>Dermanowski, Michał</creatorcontrib><creatorcontrib>Sienkiewicz-Jarosz, Halina</creatorcontrib><creatorcontrib>Kurkowska-Jastrzebska, Iwona</creatorcontrib><creatorcontrib>Bienkowski, Przemysław</creatorcontrib><creatorcontrib>Konopko, Magdalena</creatorcontrib><creatorcontrib>Dominiak, Monika</creatorcontrib><creatorcontrib>Mierzejewski, Paweł</creatorcontrib><title>Comparison of plasma, saliva, and hair lamotrigine concentrations</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>In some clinical situations (pregnancy, aging, drug resistance, toxicity), measurements of lamotrigine plasma levels may be reliable. Limited studies indicate that saliva and hair could be alternative sources for monitoring lamotrigine therapy. The drug content in hair can also be used to assess the history of drug therapy and to ascertain long-term patient compliance. The aims of this study were to 1) determine the correlations among plasma, saliva, and hair lamotrigine concentrations, 2) evaluate saliva as an alternative matrix for monitoring drug levels and 3) evaluate hair as a source of information on adherence to antiepileptic treatment and on the correlation of hair concentrations with clinical outcomes in patients with epilepsy.
Plasma, saliva, and hair lamotrigine concentrations were measured by liquid chromatography–tandem mass spectrometry in positive ionization mode. The study group (n = 85) was recruited among the epileptic patients at the Institute of Psychiatry and Neurology, Warsaw, Poland.
Plasma concentrations were not influenced by sex, age, or the concomitant use of other antiepileptic drugs. Lamotrigine saliva and plasma concentrations were strongly correlated (r = 0.82, p < 0.001). Lamotrigine hair concentrations were correlated with the plasma concentrations (r = 0.53, p < 0.001) and daily dose in mg/kg (r = 0.23, p = 0.024). The analysis revealed no significant correlation between lamotrigine hair levels and the number of seizures in the previous 3 months (r = -0.1, p > 0.05).
The lamotrigine saliva concentration is strongly correlated with its plasma level, and saliva can be used as an alternative matrix to plasma for monitoring. Lamotrigine can also be successfully measured in hair, and the drug levels in hair tend to be correlated with the levels in plasma. However, lamotrigine levels in hair may not correspond to clinical outcomes (i.e., seizure episodes).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Anticonvulsants - analysis</subject><subject>Anticonvulsants - blood</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Chromatography, Liquid</subject><subject>Drug Monitoring - methods</subject><subject>Epilepsy</subject><subject>Epilepsy - blood</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Hair</subject><subject>Hair - chemistry</subject><subject>Humans</subject><subject>Lamotrigine</subject><subject>Lamotrigine - administration & dosage</subject><subject>Lamotrigine - analysis</subject><subject>Lamotrigine - blood</subject><subject>Lamotrigine - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Poland</subject><subject>Saliva</subject><subject>Saliva - chemistry</subject><subject>Seizures - blood</subject><subject>Seizures - drug therapy</subject><subject>Tandem Mass Spectrometry</subject><subject>Young Adult</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1Lw0AQhhdRbK3-BYk3D6buR7LJHkvwCwpe9LxMNhO7JcnW3bTgv3dLq3gUXhhmeN8Z5iHkhtE5o0zer-ems0NtnVlhP-eUqTmNouqETFlZiJQrIU7JlMZRqhinE3IRwjq2PCvlOZkIJgsus3JKFpXrN-BtcEPi2mTTQejhLgnQ2V2sMDTJCqxPOujd6O2HHTAxbjA4jB5G64ZwSc5a6AJeHeuMvD8-vFXP6fL16aVaLFMjimJMsQUDktW5EDVlJlc1K9uiVXkjBJfQ0AwaLou2BClEXmcFtFJJLjFnBQpAMSO3h70b7z63GEbd22Cw62BAtw2aC8ZkxmhWRqs6WI13IXhs9cbbHvyXZlTvCeq1_kNQ7wlqGkVVzF4fz2zrHpvf5A-yaKgOBozP7ix6HYzFSKSxHs2oG2f_ceYbazCH_Q</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Kuczynska, Julita</creator><creator>Karas-Ruszczyk, Katarzyna</creator><creator>Zakrzewska, Alicja</creator><creator>Dermanowski, Michał</creator><creator>Sienkiewicz-Jarosz, Halina</creator><creator>Kurkowska-Jastrzebska, Iwona</creator><creator>Bienkowski, Przemysław</creator><creator>Konopko, Magdalena</creator><creator>Dominiak, Monika</creator><creator>Mierzejewski, Paweł</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201912</creationdate><title>Comparison of plasma, saliva, and hair lamotrigine concentrations</title><author>Kuczynska, Julita ; Karas-Ruszczyk, Katarzyna ; Zakrzewska, Alicja ; Dermanowski, Michał ; Sienkiewicz-Jarosz, Halina ; Kurkowska-Jastrzebska, Iwona ; Bienkowski, Przemysław ; Konopko, Magdalena ; Dominiak, Monika ; Mierzejewski, Paweł</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-efaca61b533b01c59b18f7f95d3326ad04ad267f8a6335b47af69626e517e3ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Anticonvulsants - analysis</topic><topic>Anticonvulsants - blood</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Chromatography, Liquid</topic><topic>Drug Monitoring - methods</topic><topic>Epilepsy</topic><topic>Epilepsy - blood</topic><topic>Epilepsy - drug therapy</topic><topic>Female</topic><topic>Hair</topic><topic>Hair - chemistry</topic><topic>Humans</topic><topic>Lamotrigine</topic><topic>Lamotrigine - administration & dosage</topic><topic>Lamotrigine - analysis</topic><topic>Lamotrigine - blood</topic><topic>Lamotrigine - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Poland</topic><topic>Saliva</topic><topic>Saliva - chemistry</topic><topic>Seizures - blood</topic><topic>Seizures - drug therapy</topic><topic>Tandem Mass Spectrometry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuczynska, Julita</creatorcontrib><creatorcontrib>Karas-Ruszczyk, Katarzyna</creatorcontrib><creatorcontrib>Zakrzewska, Alicja</creatorcontrib><creatorcontrib>Dermanowski, Michał</creatorcontrib><creatorcontrib>Sienkiewicz-Jarosz, Halina</creatorcontrib><creatorcontrib>Kurkowska-Jastrzebska, Iwona</creatorcontrib><creatorcontrib>Bienkowski, Przemysław</creatorcontrib><creatorcontrib>Konopko, Magdalena</creatorcontrib><creatorcontrib>Dominiak, Monika</creatorcontrib><creatorcontrib>Mierzejewski, Paweł</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuczynska, Julita</au><au>Karas-Ruszczyk, Katarzyna</au><au>Zakrzewska, Alicja</au><au>Dermanowski, Michał</au><au>Sienkiewicz-Jarosz, Halina</au><au>Kurkowska-Jastrzebska, Iwona</au><au>Bienkowski, Przemysław</au><au>Konopko, Magdalena</au><au>Dominiak, Monika</au><au>Mierzejewski, Paweł</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of plasma, saliva, and hair lamotrigine concentrations</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2019-12</date><risdate>2019</risdate><volume>74</volume><spage>24</spage><epage>30</epage><pages>24-30</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>In some clinical situations (pregnancy, aging, drug resistance, toxicity), measurements of lamotrigine plasma levels may be reliable. Limited studies indicate that saliva and hair could be alternative sources for monitoring lamotrigine therapy. The drug content in hair can also be used to assess the history of drug therapy and to ascertain long-term patient compliance. The aims of this study were to 1) determine the correlations among plasma, saliva, and hair lamotrigine concentrations, 2) evaluate saliva as an alternative matrix for monitoring drug levels and 3) evaluate hair as a source of information on adherence to antiepileptic treatment and on the correlation of hair concentrations with clinical outcomes in patients with epilepsy.
Plasma, saliva, and hair lamotrigine concentrations were measured by liquid chromatography–tandem mass spectrometry in positive ionization mode. The study group (n = 85) was recruited among the epileptic patients at the Institute of Psychiatry and Neurology, Warsaw, Poland.
Plasma concentrations were not influenced by sex, age, or the concomitant use of other antiepileptic drugs. Lamotrigine saliva and plasma concentrations were strongly correlated (r = 0.82, p < 0.001). Lamotrigine hair concentrations were correlated with the plasma concentrations (r = 0.53, p < 0.001) and daily dose in mg/kg (r = 0.23, p = 0.024). The analysis revealed no significant correlation between lamotrigine hair levels and the number of seizures in the previous 3 months (r = -0.1, p > 0.05).
The lamotrigine saliva concentration is strongly correlated with its plasma level, and saliva can be used as an alternative matrix to plasma for monitoring. Lamotrigine can also be successfully measured in hair, and the drug levels in hair tend to be correlated with the levels in plasma. However, lamotrigine levels in hair may not correspond to clinical outcomes (i.e., seizure episodes).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31672648</pmid><doi>10.1016/j.clinbiochem.2019.09.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Anticonvulsants - administration & dosage Anticonvulsants - analysis Anticonvulsants - blood Anticonvulsants - therapeutic use Chromatography, Liquid Drug Monitoring - methods Epilepsy Epilepsy - blood Epilepsy - drug therapy Female Hair Hair - chemistry Humans Lamotrigine Lamotrigine - administration & dosage Lamotrigine - analysis Lamotrigine - blood Lamotrigine - therapeutic use Male Middle Aged Plasma Poland Saliva Saliva - chemistry Seizures - blood Seizures - drug therapy Tandem Mass Spectrometry Young Adult |
| title | Comparison of plasma, saliva, and hair lamotrigine concentrations |
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