Mixed probiotics decrease the incidence of stage II-III necrotizing enterocolitis and death: A systematic review and meta-analysis
Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. In order to evaluate the efficacy of probiotics in the prevention of stage II-III NEC, we performed a meta-analysis of clinical studies. We searched in PubMed, Medline and Embase from 1 January 1990 to...
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| Veröffentlicht in: | Microbial pathogenesis 2020-01, Vol.138, p.103794-103794, Article 103794 |
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| creator | Jiang, Tianliang Zhang, Huai Xu, Xianrong Li, Hongjuan Yang, Jun |
| description | Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. In order to evaluate the efficacy of probiotics in the prevention of stage II-III NEC, we performed a meta-analysis of clinical studies.
We searched in PubMed, Medline and Embase from 1 January 1990 to 16 January 2018. Heterogeneity was examined by Q-test. Publication bias was evaluated by funnel plot and Egger's regression test.
30 articles were identified meeting the inclusion criteria. Data showed that probiotics supplement could significantly reduce the risk of stage II-III NEC (RR = 0.51, 95% CI, 0.38 to 0.67, P |
| doi_str_mv | 10.1016/j.micpath.2019.103794 |
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We searched in PubMed, Medline and Embase from 1 January 1990 to 16 January 2018. Heterogeneity was examined by Q-test. Publication bias was evaluated by funnel plot and Egger's regression test.
30 articles were identified meeting the inclusion criteria. Data showed that probiotics supplement could significantly reduce the risk of stage II-III NEC (RR = 0.51, 95% CI, 0.38 to 0.67, P < 0.001) and death rate (RR = 0.69, 95% CI, 0.55 to 0.87, P = 0.002). The mixed probiotics and lactobacillus could reduce the risk of stage II-III NEC (for mixed probiotics, RR = 0.39, 95% CI, 0.26 to 0.57; for lactobacillus, RR = 0.53, 95% CI, 0.36 to 0.78), while bifidobacterium or saccharomyces did not have such effect. The results also indicated that only the mixed probiotics could reduce the risk of deaths (RR = 0.52, 95%CI, 0.34 to 0.80). Subgroup analysis for mortality revealed that probiotics had significant effect in Asian region (RR = 0.54, 95% CI, 0.37 to 0.80, P = 0.002) but not in non-Asian region (RR = 0.84, 95% CI, 0.66 to 1.08, P = 0.179).
Probiotics could significantly decrease the risk of stage II-III NEC and death. Compared to using single probiotics species, the application of combining different probiotics has a better efficacy in the prevention of stage II-III NEC and death, especially in the Asian population.
•Probiotics supplement could significantly reduce the risk of stage II-III NEC and death rate.•The mixed probiotics and lactobacillus rather than bifidobacterium or saccharomyces could reduce the risk of stage II-III NEC.•Only the mixed probiotics could reduce the risk of deaths.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2019.103794</identifier><identifier>PMID: 31672528</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Meta-analysis ; Necrotizing enterocolitis ; Prevention ; Probiotics</subject><ispartof>Microbial pathogenesis, 2020-01, Vol.138, p.103794-103794, Article 103794</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-7ea76c4431e7c952f67d9acf6bcd5de3a1b35d9a9979d0de0ab4bc2ad97b7bf83</citedby><cites>FETCH-LOGICAL-c365t-7ea76c4431e7c952f67d9acf6bcd5de3a1b35d9a9979d0de0ab4bc2ad97b7bf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2019.103794$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31672528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Tianliang</creatorcontrib><creatorcontrib>Zhang, Huai</creatorcontrib><creatorcontrib>Xu, Xianrong</creatorcontrib><creatorcontrib>Li, Hongjuan</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><title>Mixed probiotics decrease the incidence of stage II-III necrotizing enterocolitis and death: A systematic review and meta-analysis</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. In order to evaluate the efficacy of probiotics in the prevention of stage II-III NEC, we performed a meta-analysis of clinical studies.
We searched in PubMed, Medline and Embase from 1 January 1990 to 16 January 2018. Heterogeneity was examined by Q-test. Publication bias was evaluated by funnel plot and Egger's regression test.
30 articles were identified meeting the inclusion criteria. Data showed that probiotics supplement could significantly reduce the risk of stage II-III NEC (RR = 0.51, 95% CI, 0.38 to 0.67, P < 0.001) and death rate (RR = 0.69, 95% CI, 0.55 to 0.87, P = 0.002). The mixed probiotics and lactobacillus could reduce the risk of stage II-III NEC (for mixed probiotics, RR = 0.39, 95% CI, 0.26 to 0.57; for lactobacillus, RR = 0.53, 95% CI, 0.36 to 0.78), while bifidobacterium or saccharomyces did not have such effect. The results also indicated that only the mixed probiotics could reduce the risk of deaths (RR = 0.52, 95%CI, 0.34 to 0.80). Subgroup analysis for mortality revealed that probiotics had significant effect in Asian region (RR = 0.54, 95% CI, 0.37 to 0.80, P = 0.002) but not in non-Asian region (RR = 0.84, 95% CI, 0.66 to 1.08, P = 0.179).
Probiotics could significantly decrease the risk of stage II-III NEC and death. Compared to using single probiotics species, the application of combining different probiotics has a better efficacy in the prevention of stage II-III NEC and death, especially in the Asian population.
•Probiotics supplement could significantly reduce the risk of stage II-III NEC and death rate.•The mixed probiotics and lactobacillus rather than bifidobacterium or saccharomyces could reduce the risk of stage II-III NEC.•Only the mixed probiotics could reduce the risk of deaths.</description><subject>Meta-analysis</subject><subject>Necrotizing enterocolitis</subject><subject>Prevention</subject><subject>Probiotics</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE9PGzEQxS0EgjTtR2jlI5cN9np3ve6lQgjKSiAu9Gx57dngaP8Ej9OSHvnkOE3olZOl8Xtv5v0I-crZgjNeXawWg7drE58WOeMqzYRUxRGZcaaqjOesPiYzVtd5VjDOzsgnxBVjTBVCnZIzwSuZl3k9I6_3_gUcXYep9VP0FqkDG8Ag0PgE1I_WOxgt0KmjGM0SaNNkTdPQMcmS4a8flxTGCGGyU--jR2pGl0LSZd_pJcUtRhhMSqYBfnv48-97gGgyM5p-ix4_k5PO9AhfDu-c_Lq5fry6ze4efjZXl3eZFVUZMwlGVrYoBAdpVZl3lXTK2K5qrSsdCMNbUaaJUlI55oCZtmhtbpySrWy7WszJ-T43lX3eAEY9eLTQ92aEaYM6F5xXohZsJy330tQRMUCn18EPJmw1Z3qHX6_0Ab_e4dd7_Mn37bBi0w7g_rveeSfBj70AUtGEI2i0fsfX-QA2ajf5D1a8AX8um8w</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Jiang, Tianliang</creator><creator>Zhang, Huai</creator><creator>Xu, Xianrong</creator><creator>Li, Hongjuan</creator><creator>Yang, Jun</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>Mixed probiotics decrease the incidence of stage II-III necrotizing enterocolitis and death: A systematic review and meta-analysis</title><author>Jiang, Tianliang ; Zhang, Huai ; Xu, Xianrong ; Li, Hongjuan ; Yang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-7ea76c4431e7c952f67d9acf6bcd5de3a1b35d9a9979d0de0ab4bc2ad97b7bf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Meta-analysis</topic><topic>Necrotizing enterocolitis</topic><topic>Prevention</topic><topic>Probiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Tianliang</creatorcontrib><creatorcontrib>Zhang, Huai</creatorcontrib><creatorcontrib>Xu, Xianrong</creatorcontrib><creatorcontrib>Li, Hongjuan</creatorcontrib><creatorcontrib>Yang, Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Tianliang</au><au>Zhang, Huai</au><au>Xu, Xianrong</au><au>Li, Hongjuan</au><au>Yang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mixed probiotics decrease the incidence of stage II-III necrotizing enterocolitis and death: A systematic review and meta-analysis</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2020-01</date><risdate>2020</risdate><volume>138</volume><spage>103794</spage><epage>103794</epage><pages>103794-103794</pages><artnum>103794</artnum><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. In order to evaluate the efficacy of probiotics in the prevention of stage II-III NEC, we performed a meta-analysis of clinical studies.
We searched in PubMed, Medline and Embase from 1 January 1990 to 16 January 2018. Heterogeneity was examined by Q-test. Publication bias was evaluated by funnel plot and Egger's regression test.
30 articles were identified meeting the inclusion criteria. Data showed that probiotics supplement could significantly reduce the risk of stage II-III NEC (RR = 0.51, 95% CI, 0.38 to 0.67, P < 0.001) and death rate (RR = 0.69, 95% CI, 0.55 to 0.87, P = 0.002). The mixed probiotics and lactobacillus could reduce the risk of stage II-III NEC (for mixed probiotics, RR = 0.39, 95% CI, 0.26 to 0.57; for lactobacillus, RR = 0.53, 95% CI, 0.36 to 0.78), while bifidobacterium or saccharomyces did not have such effect. The results also indicated that only the mixed probiotics could reduce the risk of deaths (RR = 0.52, 95%CI, 0.34 to 0.80). Subgroup analysis for mortality revealed that probiotics had significant effect in Asian region (RR = 0.54, 95% CI, 0.37 to 0.80, P = 0.002) but not in non-Asian region (RR = 0.84, 95% CI, 0.66 to 1.08, P = 0.179).
Probiotics could significantly decrease the risk of stage II-III NEC and death. Compared to using single probiotics species, the application of combining different probiotics has a better efficacy in the prevention of stage II-III NEC and death, especially in the Asian population.
•Probiotics supplement could significantly reduce the risk of stage II-III NEC and death rate.•The mixed probiotics and lactobacillus rather than bifidobacterium or saccharomyces could reduce the risk of stage II-III NEC.•Only the mixed probiotics could reduce the risk of deaths.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31672528</pmid><doi>10.1016/j.micpath.2019.103794</doi><tpages>1</tpages></addata></record> |
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| title | Mixed probiotics decrease the incidence of stage II-III necrotizing enterocolitis and death: A systematic review and meta-analysis |
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