Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders
Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflam...
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| Veröffentlicht in: | Molecular nutrition & food research 2020-02, Vol.64 (4), p.e1900550-n/a |
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| description | Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase‐1‐mediated interleukin‐1β and interleukin‐18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome‐mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant‐derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders.
The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome can sense danger signals associated with neurological diseases. Assembly of the NLRP3 inflammasome promotes interleukin‐1β and interleukin‐18 maturation in microglia. This review summarizes and highlights the current knowledge of neuroprotective effects of phytochemicals on treatment or prevention of neurological disorders through regulation of the NLRP3 inflammasome. |
| doi_str_mv | 10.1002/mnfr.201900550 |
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The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome can sense danger signals associated with neurological diseases. Assembly of the NLRP3 inflammasome promotes interleukin‐1β and interleukin‐18 maturation in microglia. This review summarizes and highlights the current knowledge of neuroprotective effects of phytochemicals on treatment or prevention of neurological disorders through regulation of the NLRP3 inflammasome.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201900550</identifier><identifier>PMID: 31675164</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Activation ; Alzheimer's disease ; Animals ; Assembly ; Caspase ; Cytokines ; Diet ; dietary phytochemicals ; Disorders ; Humans ; Immune system ; Inflammasomes ; Inflammasomes - drug effects ; Inflammasomes - metabolism ; Inflammation ; Innate immunity ; Interleukins ; Microglia ; Molecular Targeted Therapy ; Nervous system ; Nervous System Diseases - drug therapy ; Nervous System Diseases - metabolism ; Neurodegenerative diseases ; neuroinflammation ; Neurological diseases ; Neurological disorders ; Neuroprotection ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; NLRP3 inflammasome ; Pathogenesis ; Peripheral nervous system ; Phytochemicals ; Phytochemicals - chemistry ; Phytochemicals - pharmacology ; Pyrin protein ; Spinal cord injuries</subject><ispartof>Molecular nutrition & food research, 2020-02, Vol.64 (4), p.e1900550-n/a</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3680-fea78b4bd256dffd5b0369e6f1b71c1362509fbc0a4d338c4f501cb3606379fb3</citedby><cites>FETCH-LOGICAL-c3680-fea78b4bd256dffd5b0369e6f1b71c1362509fbc0a4d338c4f501cb3606379fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201900550$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201900550$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31675164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hung, Wei‐Lun</creatorcontrib><creatorcontrib>Ho, Chi‐Tang</creatorcontrib><creatorcontrib>Pan, Min‐Hsiung</creatorcontrib><title>Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase‐1‐mediated interleukin‐1β and interleukin‐18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome‐mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant‐derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders.
The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome can sense danger signals associated with neurological diseases. Assembly of the NLRP3 inflammasome promotes interleukin‐1β and interleukin‐18 maturation in microglia. This review summarizes and highlights the current knowledge of neuroprotective effects of phytochemicals on treatment or prevention of neurological disorders through regulation of the NLRP3 inflammasome.</description><subject>Activation</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Assembly</subject><subject>Caspase</subject><subject>Cytokines</subject><subject>Diet</subject><subject>dietary phytochemicals</subject><subject>Disorders</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammasomes</subject><subject>Inflammasomes - drug effects</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation</subject><subject>Innate immunity</subject><subject>Interleukins</subject><subject>Microglia</subject><subject>Molecular Targeted Therapy</subject><subject>Nervous system</subject><subject>Nervous System Diseases - drug therapy</subject><subject>Nervous System Diseases - metabolism</subject><subject>Neurodegenerative diseases</subject><subject>neuroinflammation</subject><subject>Neurological diseases</subject><subject>Neurological disorders</subject><subject>Neuroprotection</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>NLRP3 inflammasome</subject><subject>Pathogenesis</subject><subject>Peripheral nervous system</subject><subject>Phytochemicals</subject><subject>Phytochemicals - chemistry</subject><subject>Phytochemicals - pharmacology</subject><subject>Pyrin protein</subject><subject>Spinal cord injuries</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0b9vEzEUB3ALgWgprIzIEgtL0ud7ti9hQ_1BK6VpVJX55PM9J1edz8W-E8rMP45DQoYuTLbsz_vK1pexjwKmAqA4972L0wLEHEApeMVOhRY4kQLx9XFfqBP2LqUnABSFxLfsBIUuldDylP1-NHFNQ9uv-bAhvlw8rJDf9q4z3psUPPG250saY2gPh0Mb-q_8hkw3bPgqBh_-Tl85R3ZIPDh-2dJg4pavNtsh2A351pouHYO6sN4dZJZCbCim9-yNy4A-HNYz9uP66vHiZrK4_3578W0xsahnMHFkylkt66ZQunGuUTWgnpN2oi6FFagLBXNXWzCyQZxZ6RQIW6MGjWW-wDP2ZZ_7HMPPkdJQ-TZZ6jrTUxhTVaAQO4o6088v6FMYY59fl5UqxQylgqyme2VjSCmSq55j6_PXKwHVrp5qV091rCcPfDrEjrWn5sj_9ZGB3INfbUfb_8RVd8vrB9QS8A9vuZx8</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Hung, Wei‐Lun</creator><creator>Ho, Chi‐Tang</creator><creator>Pan, Min‐Hsiung</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders</title><author>Hung, Wei‐Lun ; Ho, Chi‐Tang ; Pan, Min‐Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3680-fea78b4bd256dffd5b0369e6f1b71c1362509fbc0a4d338c4f501cb3606379fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activation</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Assembly</topic><topic>Caspase</topic><topic>Cytokines</topic><topic>Diet</topic><topic>dietary phytochemicals</topic><topic>Disorders</topic><topic>Humans</topic><topic>Immune system</topic><topic>Inflammasomes</topic><topic>Inflammasomes - drug effects</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammation</topic><topic>Innate immunity</topic><topic>Interleukins</topic><topic>Microglia</topic><topic>Molecular Targeted Therapy</topic><topic>Nervous system</topic><topic>Nervous System Diseases - drug therapy</topic><topic>Nervous System Diseases - metabolism</topic><topic>Neurodegenerative diseases</topic><topic>neuroinflammation</topic><topic>Neurological diseases</topic><topic>Neurological disorders</topic><topic>Neuroprotection</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</topic><topic>NLRP3 inflammasome</topic><topic>Pathogenesis</topic><topic>Peripheral nervous system</topic><topic>Phytochemicals</topic><topic>Phytochemicals - chemistry</topic><topic>Phytochemicals - pharmacology</topic><topic>Pyrin protein</topic><topic>Spinal cord injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hung, Wei‐Lun</creatorcontrib><creatorcontrib>Ho, Chi‐Tang</creatorcontrib><creatorcontrib>Pan, Min‐Hsiung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hung, Wei‐Lun</au><au>Ho, Chi‐Tang</au><au>Pan, Min‐Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2020-02</date><risdate>2020</risdate><volume>64</volume><issue>4</issue><spage>e1900550</spage><epage>n/a</epage><pages>e1900550-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase‐1‐mediated interleukin‐1β and interleukin‐18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome‐mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant‐derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders.
The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome can sense danger signals associated with neurological diseases. Assembly of the NLRP3 inflammasome promotes interleukin‐1β and interleukin‐18 maturation in microglia. This review summarizes and highlights the current knowledge of neuroprotective effects of phytochemicals on treatment or prevention of neurological disorders through regulation of the NLRP3 inflammasome.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31675164</pmid><doi>10.1002/mnfr.201900550</doi><tpages>22</tpages></addata></record> |
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| subjects | Activation Alzheimer's disease Animals Assembly Caspase Cytokines Diet dietary phytochemicals Disorders Humans Immune system Inflammasomes Inflammasomes - drug effects Inflammasomes - metabolism Inflammation Innate immunity Interleukins Microglia Molecular Targeted Therapy Nervous system Nervous System Diseases - drug therapy Nervous System Diseases - metabolism Neurodegenerative diseases neuroinflammation Neurological diseases Neurological disorders Neuroprotection NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Pathogenesis Peripheral nervous system Phytochemicals Phytochemicals - chemistry Phytochemicals - pharmacology Pyrin protein Spinal cord injuries |
| title | Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders |
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