Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence

Magainin 2 (Mag 2), which is isolated from the skin of frogs, is a representative antimicrobial peptide (AMP), exerts its antimicrobial activity via microbial membrane disruption. It has been reported that both the amphipathicity and helical structure of Mag 2 play an important role in its antimicro...

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Veröffentlicht in:	ChemMedChem 2019-11, Vol.14 (22), p.1911-1916
Hauptverfasser:	Goto, Chihiro, Hirano, Motoharu, Hayashi, Katsuhiko, Kikuchi, Yutaka, Hara‐Kudo, Yukiko, Misawa, Takashi, Demizu, Yosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Amphipathicity Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial peptides Bacteria Cytotoxicity Disruption Frogs Gram-negative bacteria Helicity Hemolysis Magainin 2 Microorganisms Peptides Residues Toxicity α,α-disubstituted amino acids
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