Effects of regulatory T cells on glyceraldehyde-3-phosphate dehydrogenase vaccine efficacy against Schistosoma japonicum

•The protective mechanism of the GAPDH vaccine could be related to Tregs numbers.•GAPDH vaccine efficacy is improved by decreasing Treg numbers.•Enhancing Th1 and Th2 immune responses augment GAPDH vaccine efficacy. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a candidate subunit vaccine that...

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Veröffentlicht in:	Acta tropica 2020-02, Vol.202, p.105239-105239, Article 105239
Hauptverfasser:	Tang, Chun-lian, Xie, Ya-ping, Yu, Wen-hui, Jin, Lei, Xie, Zhao-lan, Li, Xiu-rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Cytokines Cytokines - immunology Female Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-Phosphate Dehydrogenases - immunology Granuloma - pathology Interleukin-2 Receptor alpha Subunit - immunology Liver - immunology Liver - pathology Mice Mice, Inbred BALB C Regulatory T cells Schistosoma japonicum Schistosoma japonicum - immunology Schistosomiasis japonica - parasitology Schistosomiasis japonica - prevention & control T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Vaccines - immunology
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