Glucagon-like peptide-1 receptor expression and its functions are regulated by androgen

Glucagon-like peptide-1 receptor (GLP-1R) is an important pharmacological target for type 2 diabetes mellitus because it maintains glucose homeostasis and promotes β cell proliferation. Androgen is suggested not only to regulate hypothalamic-pituitary-gonadal axis but also to affect metabolism. In t...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-12, Vol.120, p.109555-109555, Article 109555
Hauptverfasser:	Zhu, Liying, Zhou, Jinxing, Pan, Yu, Lv, Jing, Liu, Yang, Yu, Shanhe, Zhang, Yifan
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - pharmacology Animals Cell Line Cell Membrane - metabolism Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Proliferation - drug effects DHT/Ar Dihydrotestosterone - pharmacology Gene Expression Regulation - drug effects GLP-1R Glucagon-Like Peptide-1 Receptor - genetics Glucagon-Like Peptide-1 Receptor - metabolism Insulin Insulin Secretion - drug effects Male Mice, Inbred C57BL Models, Biological Organ Specificity Promoter Regions, Genetic - genetics Protein Transport - drug effects Receptors, Androgen - metabolism Sexual Maturation Testosterone - blood Transcription, Genetic - drug effects Type 2 diabetes mellitus
Online-Zugang:	Volltext
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