Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy
A rapid and accurate method for the sensitive detection of illegal drug additives including atenolol (ATN), metformin hydrochloride (MET), and phenformin hydrochloride (PHE) in health products using solvent microextraction (SME) combined with surface-enhanced Raman spectroscopy (SERS) was developed....
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| Veröffentlicht in: | Analyst (London) 2019-12, Vol.144 (24), p.746-7411 |
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| creator | Li, Pan He, Huan Lin, Dongyue Yang, Liangbao |
| description | A rapid and accurate method for the sensitive detection of illegal drug additives including atenolol (ATN), metformin hydrochloride (MET), and phenformin hydrochloride (PHE) in health products using solvent microextraction (SME) combined with surface-enhanced Raman spectroscopy (SERS) was developed. Various illegal drug additives in different health products were separated
via
microextraction and then detected
in situ
using a portable Raman spectrometer with Ag colloids acting as SERS-active substrates. The effects of experimental parameters on the detection sensitivity and producibility were evaluated, and the applications of illegal additives spiked into samples were systematically investigated with SME-SERS. It was demonstrated that the mixture of CH
3
OH and CHCl
3
(v/v = 1 : 4) as the extractant was suitable for the rapid microextraction separation of illegal drug additives and also induced the distribution of the Ag colloids (2 M) on the CHCl
3
surface. More importantly, CH
3
OH can carry the drug molecules to enter into the inter-particles of the Ag colloids in this process, and then significantly improve the detection sensitivity of illegal drug additives. Furthermore, the high-throughput and real-time detection of illegal drug additives spiked into health products with SME-SERS in multi-well 96 plates were achieved with the level of 0.1 μg mg
−1
. The results reveal that this rapid and convenient method could be used for the effective separation and sensitive detection of illegal additives in complex specimen.
The combined SME-SERS approach realized the effective separation and sensitive detection of illegal drug additives spiked in different healthy products. |
| doi_str_mv | 10.1039/c9an01688k |
| format | Article |
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via
microextraction and then detected
in situ
using a portable Raman spectrometer with Ag colloids acting as SERS-active substrates. The effects of experimental parameters on the detection sensitivity and producibility were evaluated, and the applications of illegal additives spiked into samples were systematically investigated with SME-SERS. It was demonstrated that the mixture of CH
3
OH and CHCl
3
(v/v = 1 : 4) as the extractant was suitable for the rapid microextraction separation of illegal drug additives and also induced the distribution of the Ag colloids (2 M) on the CHCl
3
surface. More importantly, CH
3
OH can carry the drug molecules to enter into the inter-particles of the Ag colloids in this process, and then significantly improve the detection sensitivity of illegal drug additives. Furthermore, the high-throughput and real-time detection of illegal drug additives spiked into health products with SME-SERS in multi-well 96 plates were achieved with the level of 0.1 μg mg
−1
. The results reveal that this rapid and convenient method could be used for the effective separation and sensitive detection of illegal additives in complex specimen.
The combined SME-SERS approach realized the effective separation and sensitive detection of illegal drug additives spiked in different healthy products.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/c9an01688k</identifier><identifier>PMID: 31670319</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Additives ; Atenolol - analysis ; Chloroform ; Chloroform - chemistry ; Colloiding ; Colloids - chemistry ; Drug Contamination ; Health ; Hypoglycemic Agents - analysis ; Image enhancement ; Limit of Detection ; Liquid Phase Microextraction - methods ; Metal Nanoparticles - chemistry ; Metformin ; Metformin - analysis ; Methanol - chemistry ; Parameter sensitivity ; Phenformin - analysis ; Raman spectroscopy ; Reproducibility of Results ; Sensitivity analysis ; Separation ; Silver - chemistry ; Solvents ; Solvents - chemistry ; Spectrum analysis ; Spectrum Analysis, Raman - methods ; Substrates</subject><ispartof>Analyst (London), 2019-12, Vol.144 (24), p.746-7411</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-889a816cfdb22d44228573a799d9fad9b6b5af812813dad5c362fcb981af833f3</citedby><cites>FETCH-LOGICAL-c337t-889a816cfdb22d44228573a799d9fad9b6b5af812813dad5c362fcb981af833f3</cites><orcidid>0000-0002-9038-9421 ; 0000-0002-6559-6947</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,2818,2819,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31670319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Pan</creatorcontrib><creatorcontrib>He, Huan</creatorcontrib><creatorcontrib>Lin, Dongyue</creatorcontrib><creatorcontrib>Yang, Liangbao</creatorcontrib><title>Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>A rapid and accurate method for the sensitive detection of illegal drug additives including atenolol (ATN), metformin hydrochloride (MET), and phenformin hydrochloride (PHE) in health products using solvent microextraction (SME) combined with surface-enhanced Raman spectroscopy (SERS) was developed. Various illegal drug additives in different health products were separated
via
microextraction and then detected
in situ
using a portable Raman spectrometer with Ag colloids acting as SERS-active substrates. The effects of experimental parameters on the detection sensitivity and producibility were evaluated, and the applications of illegal additives spiked into samples were systematically investigated with SME-SERS. It was demonstrated that the mixture of CH
3
OH and CHCl
3
(v/v = 1 : 4) as the extractant was suitable for the rapid microextraction separation of illegal drug additives and also induced the distribution of the Ag colloids (2 M) on the CHCl
3
surface. More importantly, CH
3
OH can carry the drug molecules to enter into the inter-particles of the Ag colloids in this process, and then significantly improve the detection sensitivity of illegal drug additives. Furthermore, the high-throughput and real-time detection of illegal drug additives spiked into health products with SME-SERS in multi-well 96 plates were achieved with the level of 0.1 μg mg
−1
. The results reveal that this rapid and convenient method could be used for the effective separation and sensitive detection of illegal additives in complex specimen.
The combined SME-SERS approach realized the effective separation and sensitive detection of illegal drug additives spiked in different healthy products.</description><subject>Additives</subject><subject>Atenolol - analysis</subject><subject>Chloroform</subject><subject>Chloroform - chemistry</subject><subject>Colloiding</subject><subject>Colloids - chemistry</subject><subject>Drug Contamination</subject><subject>Health</subject><subject>Hypoglycemic Agents - analysis</subject><subject>Image enhancement</subject><subject>Limit of Detection</subject><subject>Liquid Phase Microextraction - methods</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metformin</subject><subject>Metformin - analysis</subject><subject>Methanol - chemistry</subject><subject>Parameter sensitivity</subject><subject>Phenformin - analysis</subject><subject>Raman spectroscopy</subject><subject>Reproducibility of Results</subject><subject>Sensitivity analysis</subject><subject>Separation</subject><subject>Silver - chemistry</subject><subject>Solvents</subject><subject>Solvents - chemistry</subject><subject>Spectrum analysis</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Substrates</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkltrVDEUhYModqy--K4E-iLCqbmcS_JYBrXSUkH0-bBPLjOpOcmY5FTnL_krjZ22ghAIWfn2yk5WEHpJySklXL5TEgKhvRDfH6EV5X3bdB0Tj9GKEMIb1nftEXqW83VdUtKRp-iI034gnMoV-n3uNlu_x9mE7Iq7MVibYlRxMeBoMYQ6itMOJlOcwjotGwwZO-_NBjwGrW-rqhLw1oAvW7xLUS-qZLxkFzY4R39jQsGzUymaXyXBwV3FeXLBaPzT1aK8JAvKNCZsIaiqfoG5Hp53tZcUs4q7_XP0xILP5sXdfIy-fXj_dX3eXH7--Gl9dtkozofSCCFB0F5ZPTGm25Yx0Q0cBim1tKDl1E8dWEGZoFyD7hTvmVWTFLSqnFt-jN4cfOtFfiwml3F2WRnvIZi45JFxSgYqWzlU9OQ_9DouKdTuKsWIGEiNo1JvD1R9gJyTseMuuRnSfqRk_JvguJZnV7cJXlT49Z3lMs1GP6D3kVXg1QFIWT3s_vsC_A-6L6SH</recordid><startdate>20191202</startdate><enddate>20191202</enddate><creator>Li, Pan</creator><creator>He, Huan</creator><creator>Lin, Dongyue</creator><creator>Yang, Liangbao</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9038-9421</orcidid><orcidid>https://orcid.org/0000-0002-6559-6947</orcidid></search><sort><creationdate>20191202</creationdate><title>Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy</title><author>Li, Pan ; He, Huan ; Lin, Dongyue ; Yang, Liangbao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-889a816cfdb22d44228573a799d9fad9b6b5af812813dad5c362fcb981af833f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Additives</topic><topic>Atenolol - analysis</topic><topic>Chloroform</topic><topic>Chloroform - chemistry</topic><topic>Colloiding</topic><topic>Colloids - chemistry</topic><topic>Drug Contamination</topic><topic>Health</topic><topic>Hypoglycemic Agents - analysis</topic><topic>Image enhancement</topic><topic>Limit of Detection</topic><topic>Liquid Phase Microextraction - methods</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metformin</topic><topic>Metformin - analysis</topic><topic>Methanol - chemistry</topic><topic>Parameter sensitivity</topic><topic>Phenformin - analysis</topic><topic>Raman spectroscopy</topic><topic>Reproducibility of Results</topic><topic>Sensitivity analysis</topic><topic>Separation</topic><topic>Silver - chemistry</topic><topic>Solvents</topic><topic>Solvents - chemistry</topic><topic>Spectrum analysis</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Pan</creatorcontrib><creatorcontrib>He, Huan</creatorcontrib><creatorcontrib>Lin, Dongyue</creatorcontrib><creatorcontrib>Yang, Liangbao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Pan</au><au>He, Huan</au><au>Lin, Dongyue</au><au>Yang, Liangbao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2019-12-02</date><risdate>2019</risdate><volume>144</volume><issue>24</issue><spage>746</spage><epage>7411</epage><pages>746-7411</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><abstract>A rapid and accurate method for the sensitive detection of illegal drug additives including atenolol (ATN), metformin hydrochloride (MET), and phenformin hydrochloride (PHE) in health products using solvent microextraction (SME) combined with surface-enhanced Raman spectroscopy (SERS) was developed. Various illegal drug additives in different health products were separated
via
microextraction and then detected
in situ
using a portable Raman spectrometer with Ag colloids acting as SERS-active substrates. The effects of experimental parameters on the detection sensitivity and producibility were evaluated, and the applications of illegal additives spiked into samples were systematically investigated with SME-SERS. It was demonstrated that the mixture of CH
3
OH and CHCl
3
(v/v = 1 : 4) as the extractant was suitable for the rapid microextraction separation of illegal drug additives and also induced the distribution of the Ag colloids (2 M) on the CHCl
3
surface. More importantly, CH
3
OH can carry the drug molecules to enter into the inter-particles of the Ag colloids in this process, and then significantly improve the detection sensitivity of illegal drug additives. Furthermore, the high-throughput and real-time detection of illegal drug additives spiked into health products with SME-SERS in multi-well 96 plates were achieved with the level of 0.1 μg mg
−1
. The results reveal that this rapid and convenient method could be used for the effective separation and sensitive detection of illegal additives in complex specimen.
The combined SME-SERS approach realized the effective separation and sensitive detection of illegal drug additives spiked in different healthy products.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31670319</pmid><doi>10.1039/c9an01688k</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9038-9421</orcidid><orcidid>https://orcid.org/0000-0002-6559-6947</orcidid></addata></record> |
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| ispartof | Analyst (London), 2019-12, Vol.144 (24), p.746-7411 |
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| recordid | cdi_proquest_miscellaneous_2310719497 |
| source | MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Additives Atenolol - analysis Chloroform Chloroform - chemistry Colloiding Colloids - chemistry Drug Contamination Health Hypoglycemic Agents - analysis Image enhancement Limit of Detection Liquid Phase Microextraction - methods Metal Nanoparticles - chemistry Metformin Metformin - analysis Methanol - chemistry Parameter sensitivity Phenformin - analysis Raman spectroscopy Reproducibility of Results Sensitivity analysis Separation Silver - chemistry Solvents Solvents - chemistry Spectrum analysis Spectrum Analysis, Raman - methods Substrates |
| title | Highly sensitive detection of an antidiabetic drug as illegal additives in health products using solvent microextraction combined with surface-enhanced Raman spectroscopy |
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