mCSM-AB2: guiding rational antibody design using graph-based signatures

Abstract Motivation A lack of accurate computational tools to guide rational mutagenesis has made affinity maturation a recurrent challenge in antibody (Ab) development. We previously showed that graph-based signatures can be used to predict the effects of mutations on Ab binding affinity. Results H...

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Veröffentlicht in:	Bioinformatics 2020-03, Vol.36 (5), p.1453-1459
Hauptverfasser:	Myung, Yoochan, Rodrigues, Carlos H M, Ascher, David B, Pires, Douglas E V
Format:	Artikel
Sprache:	eng
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