Copper, dityrosine cross-links and amyloid-β aggregation

Copper is involved in Alzheimer’s disease (AD) where it appears to affect the aggregation of amyloid-β (Aβ) and to catalyze the production of reactive oxygen species (ROS). Oxidative stress apparently produces Aβ dimers that are covalently linked through two tyrosine residues. Such dityrosine cross-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of biological inorganic chemistry 2019-12, Vol.24 (8), p.1217-1229
Hauptverfasser:	Vázquez, Guillem, Caballero, Ana B., Kokinda, Jakub, Hijano, Ana, Sabaté, Raimon, Gamez, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Biochemistry Biomedical and Life Sciences Chelating agents Copper Drug development Fluorescence spectroscopy Histidine Horseradish peroxidase Inorganic chemistry Life Sciences Metal Ions and Degenerative Diseases Microbiology Original Paper Oxidative stress Peroxidase Peroxide Reactive oxygen species Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!