Brain abnormalities in myelomeningocele patients
Background Myelomeningocele (MMC) is often related to hydrocephalus and Chiari malformation (CM) type 2; however, other brain abnormalities have been reported in this population. In order to better understand and quantify other forebrain abnormalities, we analyzed magnetic resonance imaging (MRI) of...
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| Veröffentlicht in: | Child's nervous system 2020-07, Vol.36 (7), p.1507-1513 |
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| creator | Morais, Bárbara Albuquerque Solla, Davi Jorge Fontoura Yamaki, Vitor Nagai Ferraciolli, Suely Fazio Alves, Cesar Augusto P.F. Cardeal, Daniel Dante Matushita, Hamilton Teixeira, Manoel Jacobsen |
| description | Background
Myelomeningocele (MMC) is often related to hydrocephalus and Chiari malformation (CM) type 2; however, other brain abnormalities have been reported in this population. In order to better understand and quantify other forebrain abnormalities, we analyzed magnetic resonance imaging (MRI) of MMC patients treated in utero or postnatal.
Methods
Between January 2014 and March 2017, 59 MMC were treated in our hospital. Thirty-seven patients (32 postnatal and 5 intrautero repair) had brain MRI and were enrolled at the study. MRI was analyzed by two experienced neuroradiologists to identify the supra and infratentorial brain abnormalities.
Results
A wide range of brain abnormalities was consistently identified in MMC patients. As expected, the most common were hydrocephalus (94.5%) and CM type II (89.1%). Of note, we found high incidence of corpus callosum abnormalities (86.4%), mostly represented by dysplasia (46%).
Conclusions
The data are consistent with the concept that brain abnormalities related to MMC can be both infratentorial and supratentorial, cortical, and subcortical. More studies are needed to correlate these forebrain abnormalities to long-term functional outcome and their prognostic value for these patients. |
| doi_str_mv | 10.1007/s00381-019-04386-8 |
| format | Article |
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Myelomeningocele (MMC) is often related to hydrocephalus and Chiari malformation (CM) type 2; however, other brain abnormalities have been reported in this population. In order to better understand and quantify other forebrain abnormalities, we analyzed magnetic resonance imaging (MRI) of MMC patients treated in utero or postnatal.
Methods
Between January 2014 and March 2017, 59 MMC were treated in our hospital. Thirty-seven patients (32 postnatal and 5 intrautero repair) had brain MRI and were enrolled at the study. MRI was analyzed by two experienced neuroradiologists to identify the supra and infratentorial brain abnormalities.
Results
A wide range of brain abnormalities was consistently identified in MMC patients. As expected, the most common were hydrocephalus (94.5%) and CM type II (89.1%). Of note, we found high incidence of corpus callosum abnormalities (86.4%), mostly represented by dysplasia (46%).
Conclusions
The data are consistent with the concept that brain abnormalities related to MMC can be both infratentorial and supratentorial, cortical, and subcortical. More studies are needed to correlate these forebrain abnormalities to long-term functional outcome and their prognostic value for these patients.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-019-04386-8</identifier><identifier>PMID: 31664560</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Medicine ; Medicine & Public Health ; Neurosciences ; Neurosurgery ; Original Article</subject><ispartof>Child's nervous system, 2020-07, Vol.36 (7), p.1507-1513</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-4fcb8d0bc065553897e55351c01abd12001e6fa5f5708c1f0a36a746a7491d1b3</citedby><cites>FETCH-LOGICAL-c347t-4fcb8d0bc065553897e55351c01abd12001e6fa5f5708c1f0a36a746a7491d1b3</cites><orcidid>0000-0002-3240-1226</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-019-04386-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-019-04386-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31664560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morais, Bárbara Albuquerque</creatorcontrib><creatorcontrib>Solla, Davi Jorge Fontoura</creatorcontrib><creatorcontrib>Yamaki, Vitor Nagai</creatorcontrib><creatorcontrib>Ferraciolli, Suely Fazio</creatorcontrib><creatorcontrib>Alves, Cesar Augusto P.F.</creatorcontrib><creatorcontrib>Cardeal, Daniel Dante</creatorcontrib><creatorcontrib>Matushita, Hamilton</creatorcontrib><creatorcontrib>Teixeira, Manoel Jacobsen</creatorcontrib><title>Brain abnormalities in myelomeningocele patients</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Background
Myelomeningocele (MMC) is often related to hydrocephalus and Chiari malformation (CM) type 2; however, other brain abnormalities have been reported in this population. In order to better understand and quantify other forebrain abnormalities, we analyzed magnetic resonance imaging (MRI) of MMC patients treated in utero or postnatal.
Methods
Between January 2014 and March 2017, 59 MMC were treated in our hospital. Thirty-seven patients (32 postnatal and 5 intrautero repair) had brain MRI and were enrolled at the study. MRI was analyzed by two experienced neuroradiologists to identify the supra and infratentorial brain abnormalities.
Results
A wide range of brain abnormalities was consistently identified in MMC patients. As expected, the most common were hydrocephalus (94.5%) and CM type II (89.1%). Of note, we found high incidence of corpus callosum abnormalities (86.4%), mostly represented by dysplasia (46%).
Conclusions
The data are consistent with the concept that brain abnormalities related to MMC can be both infratentorial and supratentorial, cortical, and subcortical. More studies are needed to correlate these forebrain abnormalities to long-term functional outcome and their prognostic value for these patients.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EoqXwBxhQRxbDXfwRZ4SKL6kSC8yWkzhVqsQudjL03-OSwshwOunuvVfvPYRcI9whQH4fAZhCClhQ4ExJqk7IHDljFJiAUzKHTEiaA4cZuYhxC4BCZcU5mTGUkgsJcwKPwbRuaUrnQ2-6dmhtXKZBv7ed761r3cZXtrPLnUkrN8RLctaYLtqrY1-Qz-enj9UrXb-_vK0e1rRiPB8ob6pS1VBWIIUQTBW5TU1gBWjKGrOUxcrGiEbkoCpswDBpcn6oAmss2YLcTr674L9GGwfdtzEl6Yyzfow6YwhSKsF4kmaTtAo-xmAbvQttb8JeI-gDKT2R0omU_iGlVTq6OfqPZW_rv5NfNEnAJkFMK7exQW_9GFz6-T_bbyGAcqE</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Morais, Bárbara Albuquerque</creator><creator>Solla, Davi Jorge Fontoura</creator><creator>Yamaki, Vitor Nagai</creator><creator>Ferraciolli, Suely Fazio</creator><creator>Alves, Cesar Augusto P.F.</creator><creator>Cardeal, Daniel Dante</creator><creator>Matushita, Hamilton</creator><creator>Teixeira, Manoel Jacobsen</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3240-1226</orcidid></search><sort><creationdate>20200701</creationdate><title>Brain abnormalities in myelomeningocele patients</title><author>Morais, Bárbara Albuquerque ; Solla, Davi Jorge Fontoura ; Yamaki, Vitor Nagai ; Ferraciolli, Suely Fazio ; Alves, Cesar Augusto P.F. ; Cardeal, Daniel Dante ; Matushita, Hamilton ; Teixeira, Manoel Jacobsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-4fcb8d0bc065553897e55351c01abd12001e6fa5f5708c1f0a36a746a7491d1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morais, Bárbara Albuquerque</creatorcontrib><creatorcontrib>Solla, Davi Jorge Fontoura</creatorcontrib><creatorcontrib>Yamaki, Vitor Nagai</creatorcontrib><creatorcontrib>Ferraciolli, Suely Fazio</creatorcontrib><creatorcontrib>Alves, Cesar Augusto P.F.</creatorcontrib><creatorcontrib>Cardeal, Daniel Dante</creatorcontrib><creatorcontrib>Matushita, Hamilton</creatorcontrib><creatorcontrib>Teixeira, Manoel Jacobsen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morais, Bárbara Albuquerque</au><au>Solla, Davi Jorge Fontoura</au><au>Yamaki, Vitor Nagai</au><au>Ferraciolli, Suely Fazio</au><au>Alves, Cesar Augusto P.F.</au><au>Cardeal, Daniel Dante</au><au>Matushita, Hamilton</au><au>Teixeira, Manoel Jacobsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain abnormalities in myelomeningocele patients</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>36</volume><issue>7</issue><spage>1507</spage><epage>1513</epage><pages>1507-1513</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Background
Myelomeningocele (MMC) is often related to hydrocephalus and Chiari malformation (CM) type 2; however, other brain abnormalities have been reported in this population. In order to better understand and quantify other forebrain abnormalities, we analyzed magnetic resonance imaging (MRI) of MMC patients treated in utero or postnatal.
Methods
Between January 2014 and March 2017, 59 MMC were treated in our hospital. Thirty-seven patients (32 postnatal and 5 intrautero repair) had brain MRI and were enrolled at the study. MRI was analyzed by two experienced neuroradiologists to identify the supra and infratentorial brain abnormalities.
Results
A wide range of brain abnormalities was consistently identified in MMC patients. As expected, the most common were hydrocephalus (94.5%) and CM type II (89.1%). Of note, we found high incidence of corpus callosum abnormalities (86.4%), mostly represented by dysplasia (46%).
Conclusions
The data are consistent with the concept that brain abnormalities related to MMC can be both infratentorial and supratentorial, cortical, and subcortical. More studies are needed to correlate these forebrain abnormalities to long-term functional outcome and their prognostic value for these patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31664560</pmid><doi>10.1007/s00381-019-04386-8</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3240-1226</orcidid></addata></record> |
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| subjects | Medicine Medicine & Public Health Neurosciences Neurosurgery Original Article |
| title | Brain abnormalities in myelomeningocele patients |
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