Construction of Chiral 2,3‐Allenols through a Copper(I)‐Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction

Chiral 2,3‐allenols were constructed through copper(I)‐catalyzed asymmetric direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the alkynylogous aldol reaction with (R)‐DTBM‐SEGPHOS as the ligand proceeded smoothly to furnish the products in excellent regioselectivity wit...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-01, Vol.59 (4), p.1562-1566
Hauptverfasser:	Zhong, Feng, Xue, Qi‐Yan, Yin, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes aldol reaction Aliphatic compounds alkynylogous reaction allenes asymmetric catalysis Asymmetry Copper Enantiomers Esters Intermediates Ligands Neurological diseases Regioselectivity Stereoselectivity Substrates Synthesis
Online-Zugang:	Volltext
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